miR-429 inhibits glioma invasion through BMK1 suppression

Chen, Weiyi; Zhang, Baogang; Guo, Wei; Gao, Linlin; Shi, Lihong; Liu, Hongli; Lu, Shaoying; Liu, Yuqing; Li, Xiaolong

doi:10.1007/s11060-015-1887-x

Cited by 25 publications

(29 citation statements)

References 46 publications

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“…Certainly other miRNAs can target PCDH8 such as miR-429, which has been shown to be a regulator of the epithelial-to-mesenchymal transitional during embryo implantation (43). miR-429 has been shown to inhibit glioma invasion through suppression of a big mitogen-activated protein kinase (44); however the link between miR-429 and STAT3 is unknown.…”

Section: Discussionmentioning

confidence: 99%

miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis

Xue

Zhou

et al. 2016

Cancer Research

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Malignant glioma is an often fatal type of cancer. Aberrant activation of STAT3 leads to glioma tumorigenesis. STAT3- induced transcription of protein-coding genes has been extensively studied; however, little is known about STAT3-regulated miRNA gene transcription in glioma tumorigenesis. In this study, we found that abnormal activation or decreased expression of STAT3 promotes or inhibits the expression of miR-182- 5p, respectively. Bioinformatics analyses determined that tumor suppressor protocadherin-8 (PCDH8) is a candidate target gene of miR-182-5p. miR-182-5p negatively regulated PCDH8 expression by directly targeting its 3'-untranslated region. PCDH8 knockdown induced the proliferative and invasive capacities of glioma cells. Silencing of PCDH8 or miR-182-5p mimics could reverse the inhibitory effect of WP1066, a STAT3 inhibitor, or STAT3 knockdown in vitro and in vivo on glioma progression. Clinically, expression levels of PCDH8 were inversely correlated with those of p- STAT3 or miR-182-5p in glioblastoma tissues. These findings reveal that the STAT3/miR-182-5p/PCDH8 axis has a critical role in glioma tumorigenesis and that targeting the axis may provide a new therapeutic approach for human glioma.

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Section: Discussionmentioning

confidence: 99%

miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis

Xue

Zhou

et al. 2016

Cancer Research

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“…Previous reports showed that miR-372 regulates GBM cell proliferation and invasion by directly targeting PHLPP2 (7). miR-210 upregulation inhibits proliferation and induces apoptosis in GBM cells by targeting SIN3A (8) and miR-429 inhibits GBM invasion through BMK1 suppression (9).…”

Section: Introductionmentioning

confidence: 99%

The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients

Huang¹,

Zhao²,

Weng³

et al. 2016

International Journal of Oncology

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Abstract. To investigate the expression and clinical significance of miR-181a and its target genes in glioblastoma multiforme (GBM), the expression levels of miR-181a and three target genes in human normal brain tissues and GBM were analyzed in silico using gene microarray, Gene Ontology, KEGG pathway and hierarchical clustering analysis followed by validation with quantitative RT-PCR. Our results show that miR-181a is down-regulated in GBM patients. The three target genes, ANGPT2, ARHGAP18 and LAMC1, are negatively correlated with the expression of miR-181a. Moreover, high expression of ANGPT2 or LAMC1 together with large size of GBM is correlated with a shorter median overall survival. In conclusion, our results showed that miR-181a and it targets ANGPT2 and LAMC1 might be predictors of prognosis in GBM patients.

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“…Promoter hypermethylation of tumour suppressor genes is a kind of epigenetic mechanisms in cancer cells [22]. Epigenetic modifications have been shown to be crucial mediators underlying in miRNA down-regulation and to display a tight correlation with carcinogenesis [16, 23]. Our data demonstrated that the hypermethylation of the upstream promoter of miR-507 led to the down-regulation of miR-507 in breast-cancer tissues and cell lines.…”

Section: Discussionmentioning

confidence: 62%

“…Some tumor suppressor genes, such as miRNAs, can be down-regulated by promoter hypermethylation in human cancers [15, 16]. To elucidate the mechanism of miR-507 down-regulation, we performed BSP with genomic DNA to analyze the methylation level of miR-507.…”

Section: Resultsmentioning

confidence: 99%

MiR-507 inhibits the migration and invasion of human breastcancer cells through Flt-1 suppression

et al. 2016

Self Cite

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Vascular endothelial growth factor receptor-1/fms-related tyrosine kinase-1 (VEGFR-1/Flt-1) is a tyrosine kinase receptor that binds placental growth factor (PlGF). Flt-1 is also highly expressed in breast-cancer tissues and breast-cancer cell lines. However, the molecular mechanism by which Flt-1 promotes breast-cancer invasion and metastasis by binding to PlGF-1 is unclear. In this study, we discovered that PlGF-1 and Flt-1 played a key role in the migration and invasion of breast cancer. Flt-1 promoted the migration and chemotaxis of breast-cancer cells by binding to PlGF-1. In addition, Flt-1 was confirmed to be a direct target gene of miR-507. miR-507 up-regulation inhibited the invasion and metastasis of breast-cancer cells in vitro and in vivo. Flt-1 overexpression rescued the invasion partially caused by the ectopic expression of miR-507. miR-507 expression in breast-cancer tissues and cell lines was lower than that in adjacent non-neoplastic tissues and normal cells. Clinical analysis indicated that miR-507 was negatively correlated with tumor differentiation, lymphatic metastasis, and the expression of Flt-1 in breast cancer. Furthermore, we showed that miR-507 down-regulation was due to the hypermethylation of its promotor region. Our results indicated that miR-507 represented potential therapeutic targets in breast cancer by modulating Flt-1.

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miR-429 inhibits glioma invasion through BMK1 suppression

Cited by 25 publications

References 46 publications

miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis

miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis

The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients

MiR-507 inhibits the migration and invasion of human breastcancer cells through Flt-1 suppression

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