miR‐4286 promotes prostate cancer progression by targeting the expression of SALL1

Li, Zhanqi; Zhao, Shaoxiong; Wang, Hui; Zhang, Binbin; Zhang, Peibo

doi:10.1002/jgm.3127

Cited by 13 publications

(7 citation statements)

References 13 publications

(40 reference statements)

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“…Since the function of miRNAs are realized via modulating their target genes’ mRNA expression [ 26 ], we here conducted the bioinformatics analysis and verification experiment, and revealed that spalt like transcription factor 1 (SALL1) was one of the potential downstream target genes of miR-1243. The SALL1 is a member of Krüppel-associated box-containing zinc finger proteins (KRAB-ZFPs), and has been revealed to modulate the initiation and progression of human tumors [ 27 , 28 ]. SALL1 acted as a tumor suppressor gene in human glioma [ 27 ] and breast cancer ( Ma et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…SALL1 acted as a tumor suppressor gene in human glioma [ 27 ] and breast cancer ( Ma et al, 2018 ). Further, miR-4286 may exert its tumor-promoting actions, in part, by downmodulating SALL1 in prostate cancer (PCa) [ 28 ]. Based on the above studies, we hypothesized that SALL1 may be partially required for circ_0043265 to exert its anti-oncogenic effect in TSCC.…”

Section: Discussionmentioning

confidence: 99%

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Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis

Qian

Yang

Lan

et al. 2021

Pathol. Oncol. Res.

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Increasing evidence has displayed critical roles of circular RNAs (circRNAs) in tongue squamous cell carcinoma (TSCC). Hsa_circ_0043265 (circ_0043265) has been identified as a tumor suppressor in various tumors. Nevertheless, the critical roles of circ_0043265 in the initiation and progression of TSCC are yet to be fully elucidated. In our study, RNA and protein expressions were detected via qRT-PCR and Western blot. Cell proliferation, migration and invasion were evaluated via CCK-8 and transwell assays. The interactions between circ_0043265, miR-1243 and SALL1 were analyzed via bioinformatics analyses, RNA pull-down and luciferase assays, respectively. The current study demonstrated that circ_0043265 expression was downmodulated in TSCC tissues and cell lines (SCC25, SCC15, SCC9 and Cal27). Functionally, circ_0043265 overexpression led to an attenuation of cell proliferation, migration and invasion of SCC25 and Cal27 cells. Mechanistically, circ_0043265 acted as a competing endogenous RNA (ceRNA) via competitively sponging miR-1243, and restoration of miR-1243 rescued the inhibitory effects of circ_0043265 on cell proliferation, migration and invasion of SCC25 and Cal27 cells. Finally, it was observed that spalt like transcription factor 1 (SALL1), a potential target of miR-1243, was positively modulated via circ_0043265 in SCC25 and Cal27 cells, and SALL1 knockdown reversed the inhibitory effects of circ_0043265 on SCC25 and Cal27 cells. Collectively, the current study demonstrated that circ_0043265 was downmodulated in TSCC and was identified as a ceRNA that restrained the cell proliferation, migration and invasion of SCC25 and Cal27 cells via modulating the miR-1243/SALL1 axis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis

Qian

Yang

Lan

et al. 2021

Pathol. Oncol. Res.

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“…To date, numerous non-coding RNAs have been demonstrated to have a crucial role in various types of cancer, including PCa (20). For example, miR-215-5p repressed the metastasis of PCa through targeting phosphoglycerate kinase 1 (21); miR-1272 reduced the migration and invasion of PCa by targeting huntingtin interaction protein 1 (22); and the inhibition of miR-4286 inhibited the proliferation and promoted the apoptosis of PCa by targeting spalt like transcription factor 1 (23). As for the role of miR-583 in PCa, to the best of our knowledge, only one meta-analysis report exists reporting its downregulation in recurrent PCa samples compared with non-recurrent cases (18).…”

Section: Discussionmentioning

confidence: 99%

miR‑583 inhibits the proliferation and invasion of prostate cancer cells by targeting JAK1

Chen

2021

Mol Med Rep

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Prostate cancer (PCa) is a leading cause for death in men and the most commonly diagnosed malignancy globally. MicroRNA (miR)-583 expression levels have been discovered to be downregulated in recurrent PCa samples compared with non-recurrent cases. However, the precise functions and pathogenic mechanism of miR-583 in the development of PCa are vague, thus the aim of the present study was to investigate these. The expression levels of miR-583 and Janus kinase 1 (JAK1) in PCa tissues and cell lines were analyzed using reverse transcription-quantitative PCR and western blotting. The protein expression levels of phosphorylated (p)-STAT3 and STAT3 in PCa cell lines were also analyzed using western blotting. The effects of miR-583 and JAK1 on the proliferation and invasion of PCa cell lines cell lines were determined using MTT and Transwell assays, respectively. The binding interaction between miR-583 and the 3'-untranslated region of JAK1 were predicted by TargetScan, and further validated using dual luciferase reporter assays in PCa cell lines. The results revealed that the expression levels of miR-583 were downregulated, while those of JAK1 were upregulated in PCa tissues and cell lines (DU145 and PC3). The transfection with the miR-583 mimic inhibited the proliferation and invasion, as well as downregulating JAK1 and p-STAT3 protein expression levels in DU145 and PC3 cell lines. These effects were partially abolished following the overexpression of JAK1. Moreover, JAK1 was identified to be a target gene for miR-583 in DU145 and PC3 cell lines and the expression levels of miR-583 were revealed to be negatively correlated with JAK1 expression levels in PCa tissues. In conclusion, the findings of the present study suggested that miR-583 may inhibit the proliferation and invasion of PCa cells by targeting JAK1, thus providing a novel therapeutic target for patients with PCa.

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“…In cancer, Sall1 has been found to be downregulated in breast cancer, glioblastoma ( 77 ), and myeloid leukemia, supporting its role as a tumor suppressor ( 76 ). In support of such a tumor suppressor role, Sall1 has been found to be a target of oncogenic miRNAs.…”

Section: Spalt-like Transcription Factormentioning

confidence: 98%

Transcription Factors: The Fulcrum Between Cell Development and Carcinogenesis

et al. 2021

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Higher eukaryotic development is a complex and tightly regulated process, whereby transcription factors (TFs) play a key role in controlling the gene regulatory networks. Dysregulation of these regulatory networks has also been associated with carcinogenesis. Transcription factors are key enablers of cancer stemness, which support the maintenance and function of cancer stem cells that are believed to act as seeds for cancer initiation, progression and metastasis, and treatment resistance. One key area of research is to understand how these factors interact and collaborate to define cellular fate during embryogenesis as well as during tumor development. This review focuses on understanding the role of TFs in cell development and cancer. The molecular mechanisms of cell fate decision are of key importance in efforts towards developing better protocols for directed differentiation of cells in research and medicine. We also discuss the dysregulation of TFs and their role in cancer progression and metastasis, exploring TF networks as direct or indirect targets for therapeutic intervention, as well as specific TFs’ potential as biomarkers for predicting and monitoring treatment responses.

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miR‐4286 promotes prostate cancer progression by targeting the expression of SALL1

Cited by 13 publications

References 13 publications

Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis

Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis

miR‑583 inhibits the proliferation and invasion of prostate cancer cells by targeting JAK1

Transcription Factors: The Fulcrum Between Cell Development and Carcinogenesis

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