miR-375 Inhibits Differentiation of Neurites by Lowering HuD Levels

Abdelmohsen, Kotb; Hutchison, Emmette; Lee, Eun Kyung; Kuwano, Yuki; Kim, Mihee M.; Masuda, Kiyoshi; Srikantan, Subramanya; Subaran, Sarah S.; Marasa, Bernard S.; Mattson, Mark P.; Gorospe, Myriam

doi:10.1128/mcb.00316-10

Cited by 119 publications

(124 citation statements)

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“…Application of this neurotrophin induces miR-125b and ectopic expression of miR-125b promotes neurite outgrowth in a human neuroblastoma cell line (Le et al, 2009). In a similar system, BDNFinduced neurite outgrowth was inhibited after silencing HuD, a neuronal RNA-binding protein, or overexpressing miR-375 (Abdelmohsen et al, 2010). In addition, it was recently shown that miR-9 represses MAP1b translation and responds locally to BDNF to promote axon branching (Dajas-Bailador et al, 2012).…”

Section: Mirnas As Mediators Of Bdnf-induced Alteration In the Proteomementioning

confidence: 99%

BDNF-induced local protein synthesis and synaptic plasticity

2014

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a b s t r a c tBrain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and longterm potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF in LTP are mediated by TrkB (tropomyosin-related kinase B) receptors, which are known to be coupled to the activation of the Ras/ERK, phosphatidylinositol 3-kinase/Akt and phospholipase C-g (PLC-g) pathways. The role of BDNF in LTP is best studied in the hippocampus, where the neurotrophin acts at pre-and post-synaptic levels. Recent studies have shown that BDNF regulates the transport of mRNAs along dendrites and their translation at the synapse, by modulating the initiation and elongation phases of protein synthesis, and by acting on specific miRNAs. Furthermore, the effect of BDNF on transcription regulation may further contribute to long-term changes in the synaptic proteome. In this review we discuss the recent progress in understanding the mechanisms contributing to the short-and long-term regulation of the synaptic proteome by BDNF, and the role in synaptic plasticity, which is likely to influence learning and memory formation.This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'.

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Section: Mirnas As Mediators Of Bdnf-induced Alteration In the Proteomementioning

confidence: 99%

BDNF-induced local protein synthesis and synaptic plasticity

2014

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“…Though miR-375 has been previously reported as important miRNA in the pancreas and brain [31][32][33], its function is not known in melanoma. We believe that the finding that miRNA-375 is epigenetically modified contributes significantly to our understanding of the events regulating melanoma development, and will eventually lead to the development of novel diagnostic and therapeutic tools.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic regulation of microRNA‐375 and its role in melanoma development in humans

et al. 2011

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Edited by Tamas Dalmay Keywords:Epigenetic regulation MicroRNA miR-375 Cell invasion Human melanoma a b s t r a c tTo identify epigenetically regulated miRNAs in melanoma, we treated a stage 3 melanoma cell line WM1552C, with 5AzadC and/or 4-PBA. Several hypermethylated miRNAs were detected, one of which, miR-375, was highly methylated and was studied further. Minimal CpG island methylation was observed in melanocytes, keratinocytes, normal skin, and nevus but hypermethylation was observed in patient tissue samples from primary, regional, distant, and nodular metastatic melanoma. Ectopic expression of miR-375 inhibited melanoma cell proliferation, invasion, and cell motility, and induced cell shape changes, strongly suggesting that miR-375 may have an important function in the development and progression of human melanomas.

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“…These indicated that the functions of the target genes were associated with the growth of nerve and cancer cells, as previously reported (16-19). Abdelmohsen et al (18) Thei results revealed that regulation of the miR-375 expression levels affects matrix metalloproteinase 13, and markedly inhibits cancer cell migration and invasion. Lian et al (17) identified that miR-375 may target the recepteur d'origine nantais receptor and function as a tumor-suppressor in gastric cancer.…”

Section: Ppi Network and Module Constructionmentioning

confidence: 97%

Analysis of the function of microRNA-375 in humans using bioinformatics

Chen

Luo

et al. 2017

Biomedical Reports

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Abstract. ) is expressed at low levels in many types of solid tumor, particularly in gastrointestinal tumors. It is considered to be important in the development of cancer and certain diseases. Thus, more detailed knowledge is required on the particular functions of miR-375. miRs function by regulating target genes. Therefore, in the current study, miRWalk (which includes the data from 10 prediction software programs) was used to predict the target genes of miR-375. The genes, which were co-predicted using five different software programs were further analyzed using Database for Annotation, Visualization and Integrated Discovery online software [including gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis]. Subsequently, the online tool, Search Tool for the Retrieval of Interacting Genes, was used to analyze the protein-protein interaction and construct modules using Cytoscape. The result demonstrated 6,574 predicted genes, 1,325 of which were co-predicted. The GO analysis result indicated that, in biological processes, the co-predicted genes were significantly enriched in the regulation of nervous system development and cell differentiation, and the highest enrichment of molecular function was ion binding. In KEGG analysis, the genes were enriched in the Hippo signaling pathway, glutamatergic synapse, circadian entrainment and the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. The top 10 hub proteins were mechanistic target of rapamycin, PH domain and leucine rich repeat protein phosphatase 1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, histone deacetylase 2, F-box and leucine rich repeat protein 19, KIT proto-oncogene receptor tyrosine kinase, angiotensinogen, Janus kinase 2, fibroblast growth factor 2 and RNA polymerase II subunit A. These proteins predominantly regulate the development and progression of cancer, hypertension, essential thrombocythemia and inflammation. The genes in the top seven modules selected were identified to be primarily enriched in chemokines, extracellular matrix-receptor interaction, focal adhesion, the PI3K-Akt signaling pathway, amoebiasis and protein processing signaling pathway. Thus, the target genes and hub proteins that were predicted in the current study were identified to be important in regulating the development and progression of cancer and certain diseases. Furthermore, they present potential novel biomarkers for tumor diagnosis and candidate targets for treatment, and indicate that further research is required to establish the functions of miR-375.

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miR-375 Inhibits Differentiation of Neurites by Lowering HuD Levels

Cited by 119 publications

References 50 publications

BDNF-induced local protein synthesis and synaptic plasticity

BDNF-induced local protein synthesis and synaptic plasticity

Epigenetic regulation of microRNA‐375 and its role in melanoma development in humans

Analysis of the function of microRNA-375 in humans using bioinformatics

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