miR-34a inhibits proliferation, migration and invasion of paediatric neuroblastoma cells via targeting HNF4α

Li, Zhiping; Chen, Huijun

doi:10.1080/21691401.2019.1637886

Cited by 33 publications

(13 citation statements)

References 22 publications

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“…As an miRNA member, prior studies have indicated that miR-34a is deregulated in various cancers (Li et al, 2019;Liu et al, 2020;Xiu et al, 2020). Besides, it is the first miRNA found to be directly regulated by p53 (Rokavec et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2

et al. 2021

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Section: Discussionmentioning

confidence: 99%

miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2

et al. 2021

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“…HNF4α was also found to be upregulated in all invasive mucinous adenocarcinoma (IMC) of the lung determined according to tissue array, indicating that HNF4α could be considered as a useful marker for IMC of the lung (92). HNF4α expression was also found to be increased in paediatric NB tissues and negatively regulated by miR-34a to promote cancer cell proliferation and invasion (93). A study in pancreatic cancer (PDAC) indicated that HNF4α is increased in cancer tissues compared with adjacent tissues (94).…”

Section: Regulatory Roles Of Hnf4α In Human Cancersmentioning

confidence: 96%

Controversial roles of hepatocyte nuclear receptor 4 α on tumorigenesis (Review)

Zhu

Zhang

et al. 2021

Oncol Lett

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Hepatocyte nuclear receptor 4 α (HNF4α) is known to be a master transcription regulator of gene expression in multiple biological processes, particularly in liver development and liver function. To date, the function of HNF4α in human cancers has been widely investigated; however, the critical roles of HNF4α in tumorigenesis remain unclear. Numerous controversies exist, even in studies from different research groups but on the same type of cancer. In the present review, the critical roles of HNF4α in tumorigenesis will be summarized and discussed. Furthermore, HNF4α expression profile and alterations will be examined by pan-cancer analysis through bioinformatics, in order to provide a better understanding of the functional roles of this gene in human cancers.

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“…A recent analysis of clinical neuroblastoma tissue samples revealed that HNF4α promoted the invasion, metastasis, and angiogenesis of neuroblastoma cells by targeting matrix metalloproteinase 14 56 . Moreover, Li and Chen 57 reported that the overexpression of miR-34a inhibits the proliferation, migration, and invasion of human neuroblastoma SH-SY5Y cells by targeting HNF4α. Additionally, Defeng Deng et al 58 reported that the long noncoding RNA small nucleolar RNA host gene 16 plays an oncogenic role though the miR-542-3p/HNF4α axis via the RAS/RAF/ MEK/ERK signaling pathway to induce neuroblastoma growth.…”

Section: Neuroblastomamentioning

confidence: 99%

Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment

Zhou

Tang

2021

Exp Mol Med

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Hepatocyte nuclear factor 4α (HNF4α), a member of the nuclear receptor superfamily, is described as a protein that binds to the promoters of specific genes. It controls the expression of functional genes and is also involved in the regulation of numerous cellular processes. A large number of studies have demonstrated that HNF4α is involved in many human malignancies. Abnormal expression of HNF4α is emerging as a critical factor in cancer cell proliferation, apoptosis, invasion, dedifferentiation, and metastasis. In this review, we present emerging insights into the roles of HNF4α in the occurrence, progression, and treatment of cancer; reveal various mechanisms of HNF4α in cancer (e.g., the Wnt/β-catenin, nuclear factor-κB, signal transducer and activator of transcription 3, and transforming growth factor β signaling pathways); and highlight potential clinical uses of HNF4α as a biomarker and therapeutic target for cancer.

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miR-34a inhibits proliferation, migration and invasion of paediatric neuroblastoma cells via targeting HNF4α

Abstract: View related articles View Crossmark data Citing articles: 1 View citing articles miR-34a inhibits proliferation, migration and invasion of paediatric neuroblastoma cells via targeting HNF4a

Cited by 33 publications

References 22 publications

miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2

miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2

Controversial roles of hepatocyte nuclear receptor 4 α on tumorigenesis (Review)

Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment

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