MiR-34a-5p/Sirt1 axis: A novel pathway for puerarin-mediated hepatoprotection against benzo( )pyrene

Hao, Rili; Ge, Junlin; Li, Feng; Jiang, Yang; Sun‐Waterhouse, Dongxiao; Li, Dapeng

doi:10.1016/j.freeradbiomed.2022.05.006

Cited by 7 publications

(7 citation statements)

References 53 publications

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“…MiR-34a-5p/Sirt1 axis may be associated with puerarin inhibited BaPcaused liver damage in mice and HepG2 cells through inhibiting apoptosis and inflammation (Hao et al, 2022). MiR-141 is believed to participate in UV-induced oxidative damage in RPEs and RGCs cells via Keap1/Nrf2 pathway (Cheng et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…MiR‐34a/Sirt1/p53 was revealed to be associated with CAPE against Cd‐caused kidney damage in mice via suppressing inflammation and apoptosis (Hao, Sun‐Waterhouse, et al., 2021). MiR‐34a‐5p/Sirt1 axis may be associated with puerarin inhibited BaP‐caused liver damage in mice and HepG2 cells through inhibiting apoptosis and inflammation (Hao et al., 2022). MiR‐141 is believed to participate in UV‐induced oxidative damage in RPEs and RGCs cells via Keap1/Nrf2 pathway (Cheng et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

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The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Hao

Zhou

et al. 2023

Food Frontiers

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Cadmium (Cd) is a heavy metal toxic that can cause health problems including lung injury. This study was set out to meet the growing demand for effective treatment of lung diseases and explore the mechanism of caffeic acid phenethyl ester (CAPE, a natural phenolic acid) protect against Cd‐caused lung damage. In this study, CAPE significantly increased mice body weight, decreased lung W/D ratio, and alleviated histomorphological injury. CAPE mitigated CdCl2‐induced oxidative stress through Nrf2/HO‐1/NQO1 pathway, suppressed inflammation via MyD88/NF‐κB pathway, and alleviated apoptosis by modulating apoptosis mediators. CAPE also inhibited the CdCl2‐caused decreasing of TLR4 level and the increasing of miR‐182‐5p level, which is achieved by miR‐182‐5p sponging TLR4. Collectively, miR‐182‐5p is involved in CAPE against CdCl2‐caused lung damage by targeting TLR4. MiR‐182‐5p/TLR4 is a new pathway for inhibiting oxidative stress, apoptosis, and inflammation in CAPE‐mediated lung protection, which provides a novel avenue for treatment therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Hao

Zhou

et al. 2023

Food Frontiers

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“…Kidney histopathology was evaluated by H&E staining and sirius red staining, and cell growth status was evaluated by crystal violet staining. , Details are supplied in Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

“…The viability of HK-2 cell was measured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2 H -tetrazolium bromide). , The Supporting Information gives more details regarding the process.…”

Section: Methodsmentioning

confidence: 99%

Nuciferine Protects against Obesity-Induced Nephrotoxicity through Its Hypolipidemic, Anti-Inflammatory, and Antioxidant Effects

Zhu,

Si,

Hao

et al. 2023

J. Agric. Food Chem.

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“…Puerarin significantly increased the levels of antioxidant markers such as superoxide dismutase, glutathione peroxidase, and catalase in serum and liver of NAFLD, and decreased the levels of TNF-α, IL-18, and IL-1β ( Zhou J. F. et al, 2022 ). Puerarin also mediates hepatoprotective effects by inhibiting oxidative stress and inflammation through the microRNA (miR)-34a-5p/Sirt1 axis ( Hao et al, 2022 ). The efficacy of puerarin against preeclampsia is also related to its anti-inflammatory effect ( Guo et al, 2022 ).…”

Section: Puerarin Regulates Pi3k/akt Signal Pathway To Protect the Ne...mentioning

confidence: 99%

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

et al. 2022

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Neurological diseases impose a tremendous and increasing burden on global health, and there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried root of Pueraria montana var. Lobata (Willd.) Sanjappa and Predeep, is an active ingredient with anti-inflammatory, antioxidant, anti-apoptotic, and autophagy-regulating effects. It has great potential in the treatment of neurological and other diseases. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/Akt) signal pathway is a crucial signal transduction mechanism that regulates biological processes such as cell regeneration, apoptosis, and cognitive memory in the central nervous system, and is closely related to the pathogenesis of nervous system diseases. Accumulating evidence suggests that the excellent neuroprotective effect of puerarin may be related to the regulation of the PI3K/Akt signal pathway. Here, we summarized the main biological functions and neuroprotective effects of puerarin via activating PI3K/Akt signal pathway in neurological diseases. This paper illustrates that puerarin, as a neuroprotective agent, can protect nerve cells and delay the progression of neurological diseases through the PI3K/Akt signal pathway.

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MiR-34a-5p/Sirt1 axis: A novel pathway for puerarin-mediated hepatoprotection against benzo( )pyrene

Cited by 7 publications

References 53 publications

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Nuciferine Protects against Obesity-Induced Nephrotoxicity through Its Hypolipidemic, Anti-Inflammatory, and Antioxidant Effects

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

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