MiR‐3130‐5p is an intermediate modulator of 2q33 and influences the invasiveness of lung adenocarcinoma by targeting NDUFS1

Zhan, Juan; Sun, Shenghua; Chen, Yixing; Xu, Chaoqun; Chen, Qinwei; Li, Minjie; Pei, Yihua; Li, Qiyuan

doi:10.1002/cam4.3885

Cited by 11 publications

(7 citation statements)

References 49 publications

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“…For example, Yu F and colleagues demonstrated that exosomal miR‐31‐5p derived from hypoxic tumor targeted SATB2 and activated MEK/ERK signaling to facilitate tumor metastasis in LUAD, 32 and Zhan J et al demonstrated that miR‐3130‐5p could drive the growth, metastasis, and EMT progress in LUAD through directly mediating NDUFS1. 33 In addition, Liu H et al revealed the carcinogenic role of miR‐301b‐3p in inducing LUAD cell proliferation, migration, and invasion via inhibiting DLC1. 34 Consistent with previous research, we found that miR‐423‐3p was highly expressed in LUAD and the high expression miR‐423‐3p predicted poor survival probability in non‐smoked, aged over 65, and pathological stage 1 LUAD patients.…”

Section: Discussionmentioning

confidence: 99%

miR‐423‐3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

Huang

Zhu

et al. 2021

Clinical Laboratory Analysis

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Lung cancer is a malignant tumor originated from the bronchial mucosa or glands of the lungs, 1,2 which has characteristics of family clustering and genetic susceptibility. 3,4 According to preventive pathology, lung cancer is classified into two categories: small cell carcinoma and non-small-cell carcinoma. 5 Among them, non-smallcell carcinoma includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. 6 Lung adenocarcinoma (LUAD) is a type of lung cancer, accounting for 40%-55% in all lung cancer cases.

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Section: Discussionmentioning

confidence: 99%

miR‐423‐3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

Huang

Zhu

et al. 2021

Clinical Laboratory Analysis

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“…Several frailty-related SNPs were associated with diverse kinds of cancer. CPO -rs10179420 was reported to be associated with lung adenocarcinoma [49], ZNRD1ASP -rs6928966 with breast cancer [50], and PRKAA1 -rs1002424 with gastric cancer [51]. Furthermore, some SNPs were related to many kinds of cancer.…”

Section: Discussionmentioning

confidence: 99%

“…HR, hazard ratio; CI, confidence interval. to be associated with lung adenocarcinoma [49], ZNRD1ASP-rs6928966 with breast cancer [50], and PRKAA1-rs1002424 with gastric cancer [51]. Furthermore, some SNPs were related to many kinds of cancer.…”

Section: Association Between Prs and Frailtymentioning

confidence: 99%

Leisure Activities, Genetic Risk, and Frailty: Evidence from the Chinese Adults Aged 80 Years or Older

Zhou

Gao

et al. 2023

Gerontology

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Introduction: About half of adults aged ≥ 80 years suffer from frailty. Exercise is considered effective in preventing frailty but may be inapplicable to adults aged ≥ 80 years due to physical limitations. As an alternative, we aimed to explore the association of leisure activities with frailty and identify potential interaction with established polygenic risk score (PRS) among adults aged ≥ 80 years. Methods: Analyses were performed in a prospective cohort study of 7471 community-living older adults aged ≥ 80 years who were recruited between 2002 and 2014 from 23 provinces in China. Leisure activity was assessed using a seven-question leisure activity index and frailty was defined as a frailty index ≥ 0.25 using a validated 39-item health-related scale. The PRS was constructed using 59 single-nucleotide polymorphisms associated with frailty in a subsample of 2541 older adults. Cox proportional hazards models were used to explore the associations of leisure activities, PRS with frailty. Results: The mean age of participants was 89.4 ± 6.6 years (range: 80–116). In total, 2930 cases of frailty were identified during 42,216 person-years of follow-up. Each 1 unit increase in the leisure activity index was associated with 12% lower risk of frailty (hazard ratio [HR]: 0.88 [95%CI, 0.85-0.91]). Participants with high genetic risk (PRS>2.47×10-4) suffered from 26% higher risk of frailty. Interaction between leisure activity and genetic risk was not observed. Conclusion: Evidence is presented for the independent association of leisure activities and genetic risk with frailty. Engagement in leisure activities suggested to be associated with lower risk of frailty across all levels of genetic risk among adults aged ≥ 80 years.

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“…Our miR-eQTL data analysis strengthens the interpretation of genome functionality and provides a valuable framework for the biological understanding of cancer risk. Exploration of the mechanisms of action of the identified miR-eQTLs in this study could lead us to discover networks of dysregulated miRNA and isomiRs contributing to cancers [ 47 , 48 ]. Further studies are required to investigate the functional impact of these miR and isomiR-eQTLs.…”

Section: Discussionmentioning

confidence: 99%

IsomiR-eQTL: A Cancer-Specific Expression Quantitative Trait Loci Database of miRNAs and Their Isoforms

Moradi

Whatmore

Farashi

et al. 2022

IJMS

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The identification of expression quantitative trait loci (eQTL) is an important component in efforts to understand how genetic variants influence disease risk. MicroRNAs (miRNAs) are short noncoding RNA molecules capable of regulating the expression of several genes simultaneously. Recently, several novel isomers of miRNAs (isomiRs) that differ slightly in length and sequence composition compared to their canonical miRNAs have been reported. Here we present isomiR-eQTL, a user-friendly database designed to help researchers find single nucleotide polymorphisms (SNPs) that can impact miRNA (miR-eQTL) and isomiR expression (isomiR-eQTL) in 30 cancer types. The isomiR-eQTL includes a total of 152,671 miR-eQTLs and 2,390,805 isomiR-eQTLs at a false discovery rate (FDR) of 0.05. It also includes 65,733 miR-eQTLs overlapping known cancer-associated loci identified through genome-wide association studies (GWAS). To the best of our knowledge, this is the first study investigating the impact of SNPs on isomiR expression at the genome-wide level. This database may pave the way for researchers toward finding a model for personalised medicine in which miRNAs, isomiRs, and genotypes are utilised.

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MiR‐3130‐5p is an intermediate modulator of 2q33 and influences the invasiveness of lung adenocarcinoma by targeting NDUFS1

Cited by 11 publications

References 49 publications

miR‐423‐3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

miR‐423‐3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

Leisure Activities, Genetic Risk, and Frailty: Evidence from the Chinese Adults Aged 80 Years or Older

IsomiR-eQTL: A Cancer-Specific Expression Quantitative Trait Loci Database of miRNAs and Their Isoforms

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