miR-301b-3p Regulates Breast Cancer Cell Proliferation, Migration, and Invasion by Targeting NR3C2

Fan, Yun; Li, Yan; Zhu, Yuzhang; Dai, Gui-Ping; Wu, Debo; Gao, Zhenzhen; Zhang, Lei; Xu, Danying

doi:10.1155/2021/8810517

Cited by 23 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fan and colleagues demonstrated that miR-301b-3p was significantly elevated in breast cancer. Furthermore, miR-301b-3p accelerated cell proliferation, migration, and invasion through binding to NR3C2 18 . Also, Liu and coworkers revealed that miR-301b-3p promoted lung adenocarcinoma malignancy through suppressing DLC1 expression [19].…”

Section: Discussionmentioning

confidence: 99%

“…demonstrated that miR-140-3p attenuated CRC progression and liver metastasis via BCL9 transcription coactivator (BCL9) and BCL2 apoptosis regulator (BCL2) [ 17 ]. Previous studies identified that miR-301b-3p was associated with the development of several carcinomas, such as breast cancer [ 18 ], lung adenocarcinoma [ 19 ], gastric cancer [ 20 ], and hepatocellular carcinoma [ 21 ]. However, the potential functions and possible mechanisms of miR-301b-3p in CRC were largely unclear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1

et al. 2021

View full text Add to dashboard Cite

Previous studies revealed that miR-301b-3p was essential to the onset and development of several cancers, but the implied functions of miR-301b-3p in colorectal cancer (CRC) remained largely unclear. The current study is aimed to exploring the potential roles and possible mechanism of miR-301b-3p in CRC. The abundance of miR-301b-3p and HOXB1 in CRC clinical specimens and cell lines was verified using RT-qPCR. The CCK-8, colony formation, wound healing and transwell assays were adopted to evaluate cell proliferation and migration. The interactivity of miR-301b-3p and homeobox B1 (HOXB1) was identified using bioinformatics analysis and dual-luciferase reporter. The results of RT-qPCR indicated that miR-301b-3p was significantly upregulated in CRC clinical specimens and cell lines. Furthermore, overexpression of miR-301b-3p speeds up CRC cell proliferation and migration. Bioinformatics analysis and dual-luciferase reporter verified that HOXB1 acted as the downstream targeted mRNA. Furthermore, silencing of HOXB1 also obviously accelerated the proliferation and migration ability of CRC cells. miR-301b-3p facilitated cell proliferation and migration in CRC, which was partly reversed by overexpressing HOXB1. In conclusion, our findings demonstrated that miR-301b-3p facilitated CRC cell growth and migration via targeting HOXB1. Our results identified that miR-301b-3p served as a significant oncogene in CRC, which may provide a novel biomarker for diagnosis and therapeutic objective for CRC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Fan et al. found that the expression of NR3C2 was downregulated in breast cancer ( 52 ). High expression of NR3C2 was significantly correlated with prolonged OS ( 53 ).…”

Section: Discussionmentioning

confidence: 99%

“…High expression of NR3C2 was significantly correlated with prolonged OS ( 53 ). Overexpression NR3C2 could repress the proliferation, migration, and invasion for breast cancer and hepatocellular carcinoma ( 52 , 54 ). Consistent with previous studies, NR3C2 was decreased in patients with KIRC.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Ferroptosis- and Immune-Related Signatures to Improve the Prognosis and Diagnosis of Kidney Renal Clear Cell Carcinoma

Xing

Liu

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

BackgroundAlmost 40% of patients with kidney renal clear cell carcinoma (KIRC) with advanced cancers eventually develop to metastases, and their 5-year survival rates are approximately 10%. Aberrant DNA methylations are significantly associated with the development of KIRC. The aim of our present study was to identify suitable ferroptosis- and immune-related (FI) biomarkers correlated with aberrant methylations to improve the prognosis and diagnosis of KIRC.MethodsChAMP and DESeq2 in R (3.6.2) were used to screen the differentially expressed methylation probes and differentially expressed genes, respectively. Univariate and multivariate Cox regression were used to identify the overall survival (OS)–related biomarkers.ResultsWe finally identified five FI biomarkers (CCR4, CMTM3, IFITM1, MX2, and NR3C2) that were independently correlated with the OS of KIRC. The area under the curve value of the receiver operating characteristic value of prognosis model was 0.74, 0.68, and 0.72 in the training, validation, and entire cohorts, respectively. The sensitivity and specificity of the diagnosis model were 0.8698 and 0.9722, respectively. In addition, the prognosis model was also significantly correlated with several immune cells and factors.ConclusionOur present study suggested that these five FI-DEGs (CCR4, CMTM3, IFITM1, MX2, and NR3C2) could be used as prognosis and diagnosis biomarkers for patients with KIRC, but further cross-validation clinical studies are still needed to confirm them.

show abstract

“…Studies in various countries have shown that NR3C2 acted as a tumor suppressor gene in a variety of tumors. The NR3C2 gene can inhibit tumor cell proliferation, migration and invasion [40][41][42][43] . In addition, the NR3C2 gene is closely associated with the prognostic status of patients with BRCA: the less it is expressed, the worse the prognosis [39][40] .…”

Section: Discussionmentioning

confidence: 99%

Two targets that play a role in the immune microenvironment of breast cancer

Wang

Zhou

et al. 2022

Preprint

View full text Add to dashboard Cite

Breast cancer (BRCA) is a malignancy that occurs in breast epithelium or ductal epithelium. The progression of BRCA is greatly influenced by the tumor microenvironment (TME). Studies have shown that Pachymic acid (PA) had an inhibitory effect on the proliferation and metastasis of BRCA cells and could also enhance immunity. We planned to use the methods of network pharmacology and bio-information analysis to clarify the role of this molecule in the TME of BRCA and its target. We predicted the potential targets of PA. In addition, by comparing the cancer profiles in the The Tumor Genome Atlas (TCGA) genome with normal profiles, differentially expressed genes (DEGs) were obtained. At the intersection of predicted targets and DEGs were 16 important genes. Enrichment analysis and survival analysis were performed on these genes. Two hub genes were found in combination with the RNA-seq expression and protein expression in T cell subsets by Immunohistochemical analysis. Finally, we used the GSE42568 data to construct a risk prediction model and obtained independent prognostic indicators. And we identified two PA targets that played a role in the TME, thus providing new ideas for research on BRCA.

show abstract

miR-301b-3p Regulates Breast Cancer Cell Proliferation, Migration, and Invasion by Targeting NR3C2

Cited by 23 publications

References 26 publications

MicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1

MicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1

Comprehensive Analysis of Ferroptosis- and Immune-Related Signatures to Improve the Prognosis and Diagnosis of Kidney Renal Clear Cell Carcinoma

Two targets that play a role in the immune microenvironment of breast cancer

Contact Info

Product

Resources

About