miR-29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP-2

Qi, Y; Li, X; Zhao, Shuliang

doi:10.4149/neo_2015_046

Cited by 21 publications

(11 citation statements)

References 29 publications

(34 reference statements)

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“…Yuan et al have found that miR-29b as a suppressor could inhibit the growth of colorectal cancer cells by binding IGIF1, an activator of PI3K/Akt signaling [ 16 ]. In 2015, Qi et al proved that the overexpression of miR-29b significantly reduced the protein of MMP-2 which suppressed the cell invasion of esophageal squamous cell carcinoma [ 17 ]. Meanwhile, the miR-29b was suggested to inhibit the migration and invasion of nasopharyngeal carcinoma cell lines in vitro [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma

Luan

Wang

et al. 2016

Oncotarget

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MicroRNAs(miRNAs), as non-coding molecules, were proved to be correlated with gene expression in naspharyngeal carcinoma (NPC) development. In this research, a comprehensive meta-analysis of eight independent miRNA expression studies in NPC was preformed by using robust rank aggregation method (RRA), which contained a total of 775 tumor and 227 non-cancerous samples. There were 7 significant dysregulated miRNAs identified including three increased (miR-483–5p, miR-29c-3p and miR-205–5p) and four decreased (miR-29b-3p, let-7d-5p, miR-100– 5p and let-7g-5p) miRNAs. Subsequently, the miRNA target prediction and pathway enrichment analysis were carried out to find out the biological and functional relevant genes involved in the meta-signature miRNA regulation. Finally, several signaling and cancer pathogenesis pathways were suggested to be more frequently associated with the progression of NPC. In this research the meta-signature miRNA identified may be used to develop a series of diagnostic and prognostic biomarkers for NPC that serve specificity for use in clinics.

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Section: Discussionmentioning

confidence: 99%

Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma

Luan

Wang

et al. 2016

Oncotarget

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“…However, it is worth to note that miR-29b acts as a tumour suppressor in other cancer tissues. Indeed, mir-29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP-2 42 . In breast cancer, miR-29b expression is negatively associated with the HER2 sub-type, and its overexpression inhibits breast cancer cell proliferation and induces apoptosis mainly downregulating STAT3 protein levels 43 .…”

Section: Discussionmentioning

confidence: 99%

PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in rat thyroid cells

Vitiello

Valentino

Menna

et al. 2016

Sci Rep

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The regulatory transcriptional factor PATZ1 is constantly downregulated in human thyroid cancer where it acts as a tumour suppressor by targeting p53-dependent genes involved in Epithelial-Mesenchymal Transition and cell migration. The aim of the present work was to elucidate the upstream signalling mechanisms regulating PATZ1 expression in thyroid cancer cells. The bioinformatics search for microRNAs able to potentially target PATZ1 led to the identification of several miRNAs. Among them we focused on the miR-29b since it was found upregulated in rat thyroid differentiated cells transformed by the Ha-Ras oncogene towards a high proliferating and high migratory phenotype resembling that of anaplastic carcinomas. Functional assays confirmed PATZ1 as a target of miR-29b, and, consistently, an inverse correlation between miR-29b and PATZ1 protein levels was found upon induction of Ha-Ras oncogene expression in these cells. Interestingly, restoration of PATZ1 expression in rat thyroid cells stably expressing the Ha-Ras oncogene decreased cell proliferation and migration, indicating a key role of PATZ1 in Ras-driven thyroid transformation. Together, these results suggest a novel mechanism regulating PATZ1 expression based on the upregulation of miR-29b expression induced by Ras oncogene.

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“…In addition, inhibition of CCAT2 decreased the expression levels of b-catenin/WISP1 downstream targets VEGF-A, MMP2, and ICAM-1, which play vital roles in cancer angiogenesis, migration, and invasion. [38][39][40] Targeting the CCAT2/b-catenin/WISP1 axis may inhibit metastasis and increase radiotherapy sensitivity in ESCC patients by reversing the EMT-associated progression. Moreover, patients with high expression levels of both CCAT2 and WISP1 had the worst prognosis, suggesting that CCAT2 combined with WISP1 may be prognostic biomarkers for ESCC.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of long non-coding RNA CCAT2 suppresses growth and metastasis of esophageal squamous cell carcinoma by inhibiting the β-catenin/WISP1 signaling pathway

Yang

Zhou

et al. 2021

J Int Med Res

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Objective Long non-coding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) plays oncogenic roles in several cancers, including esophageal squamous cell carcinoma (ESCC). However, the specific mechanism of how CCAT2 influences ESCC tumorigenesis is still unknown. Methods Using RT-qPCR, the mRNA expression levels of CCAT2 in 33 paired ESCC and adjacent non-cancer tissues and cell lines were measured. Lentiviral vector sh-CCAT2 was designed and transfected into TE10 cells. CCK-8 and transwell assays were employed to detect the effects of CCAT2 knockdown on cell proliferation and invasion, respectively. RT-qPCR and western blots were used to detect the effects of CCAT2 knockdown. Results CCAT2 was overexpressed in ESCC tissues compared with corresponding adjacent tissues. CCAT2 knockdown could suppress cell proliferation and invasion in vitro. Furthermore, knockdown of CCAT2 could suppress the mRNA and protein levels of β-catenin and Wnt-induced-secreted-protein-1 (WISP1), as well as the mRNA levels of their downstream targets VEGF-A, MMP2, and ICAM-1. High expression of CCAT2 and WISP1 were associated with poor prognosis of ESCC patients. Conclusions In conclusion, a novel CCAT2/β-catenin/WISP1 axis was revealed in ESCC progression and may provide a promising therapeutic target against ESCC. CCAT2 and WISP1 are potential molecular biomarkers for predicting prognosis of ESCC.

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miR-29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP-2

Cited by 21 publications

References 29 publications

Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma

Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma

PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in rat thyroid cells

Knockdown of long non-coding RNA CCAT2 suppresses growth and metastasis of esophageal squamous cell carcinoma by inhibiting the β-catenin/WISP1 signaling pathway

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