miR-26 family and its target genes in tumorigenesis and development

Li, Chuangang; Li, Yongyi; Lü, Yongtao; Niu, Zhaorui; Zhao, Henan; Peng, Yan; Li, Molin

doi:10.1016/j.critrevonc.2020.103124

Cited by 44 publications

(39 citation statements)

References 96 publications

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“…MiR-26a belongs to the microRNA-26 family, which can be induced by hypoxia and upregulated during multiple cell differentiation, participating in the development of normal tissues and many pathological processes. 46 It has been reported that miR-26a plays an effective role in bone regeneration through positive regulation of angiogenic-osteogenic coupling. Moreover, exosomal miR-26a can promote angiogenesis of microvessel HUVECs in glioma.…”

Section: Discussionmentioning

confidence: 99%

SHED aggregate exosomes shuttled miR‐26a promote angiogenesis in pulp regeneration via TGF‐β/SMAD2/3 signalling

Xuan

Liu

et al. 2021

Cell Proliferation

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Section: Discussionmentioning

confidence: 99%

SHED aggregate exosomes shuttled miR‐26a promote angiogenesis in pulp regeneration via TGF‐β/SMAD2/3 signalling

Xuan

Liu

et al. 2021

Cell Proliferation

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“…As vertebrate-specific miRNAs, miR-26 family members have been detected in many different kinds of tumors and play important roles in cardiovascular disease, Parkinson's disease, neurodegenerative diseases, and many other non-tumor diseases (Gao and Liu, 2011 ; Icli et al, 2014 ; Goh et al, 2019 ; Su et al, 2019 ). The validated target genes of these miRNAs are involved in cell metabolism, proliferation, differentiation, apoptosis, autophagy, invasion, and metastasis (Lagos-Quintana et al, 2002 ; Li et al, 2020 ). In some tumors, the differential expression pattern of miR-26 might be related to specific tumorigenic processes.…”

Section: Discussionmentioning

confidence: 99%

Differentially Expressed MiRNAs of Goat Submandibular Glands Among Three Developmental Stages Are Involved in Immune Functions

Wang

Xuan

et al. 2021

Front. Genet.

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Submandibular glands (SMGs) are one of the primary components of salivary glands in goats. The proteins and biologically active substances secreted by the SMGs change with growth and development. Our previous studies showed that most of the differentially expressed genes in the SMGs of goats at different developmental stages are involved in immune-related signaling pathways, but the miRNA expression patterns in the same tissues are unknown. The aim of this study was to reveal the expression profile of miRNAs at three different developmental stages, detect differentially expressed miRNAs (DE miRNAs) and predict disease-related DE miRNAs. SMG tissue samples were collected from groups of 1-month-old kids, 12-month-old maiden goats and 24-month-old adult goats (three samples from each group), and high-throughout transcriptome sequencing was conducted. A total of 178, 241 and 7 DE miRNAs were discovered between 1-month-old kids and 12-month-old maiden goats, between 1-month-old kids and 24-month-old adult goats, and between 12-month-old maiden goats and 24-month-old adult goats, respectively. Among these DE miRNAs, 88 DE miRNAs with medium or high expression levels (TPM ≥50) were classified into five expression pattern clusters. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses indicated that some of the predicted target genes of the DE miRNAs in the five clusters were enriched in disease-related GO terms and pathways. MiRNA target genes in significant pathways were significantly enriched in Hepatitis B (FDR = 9.03E-10) and Pathways in cancer (FDR = 4.2E-10). Further analysis was performed with a PPI network, and 10 miRNAs were predicted to play an important role in the occurrence and prevention of diseases during the growth and development of goats.

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“…MirRNA-26 is involved in the occurrence and progression of a variety of diseases [ 143 , 144 , 145 ], among which mir-26b has been shown to be a tumor suppressor in most studies and has been proved to be related to the sensitivity of cancer chemotherapy in several studies, such as improving the sensitivity of colon cancer cells to 5-FU [ 146 ], inhibiting the resistance of gastric cancer cells to paclitaxel [ 147 ], and enhancing the potency of cisplatin in lung cancer cells [ 148 ]. Chemotherapy resistance is often associated with autophagy.…”

Section: Mirnas Are Involved In Autophagy Via Dubs Regulationmentioning

confidence: 99%

Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System

Lin

2021

IJMS

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MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by endogenous genes with ~22 nucleotides which are involved in the regulation of post-transcriptional gene expression. Ubiquitination and deubiquitination are common post-translational modifications in eukaryotic cells and important pathways in regulating protein degradation and signal transduction, in which E3 ubiquitin ligases and deubiquitinases (DUBs) play a decisive role. MiRNA and ubiquitination are involved in the regulation of most biological processes, including autophagy. Furthermore, in recent years, the direct interaction between miRNA and E3 ubiquitin ligases or deubiquitinases has attracted much attention, and the cross-talk between miRNA and ubiquitination system has been proved to play key regulatory roles in a variety of diseases. In this review, we summarized the advances in autophagy regulation by crosstalk between miRNA and E3 ubiquitin ligases or deubiquitinases.

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miR-26 family and its target genes in tumorigenesis and development

Cited by 44 publications

References 96 publications

SHED aggregate exosomes shuttled miR‐26a promote angiogenesis in pulp regeneration via TGF‐β/SMAD2/3 signalling

SHED aggregate exosomes shuttled miR‐26a promote angiogenesis in pulp regeneration via TGF‐β/SMAD2/3 signalling

Differentially Expressed MiRNAs of Goat Submandibular Glands Among Three Developmental Stages Are Involved in Immune Functions

Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System

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