miR-223: An Immune Regulator in Infectious Disorders

Yuan, Shenfang; Wu, Qi; Wang, Zhiwei; Che, Yanjia; Zheng, Shu-Jian; Chen, Yuanyang; Zhong, Xiaohan; Shan, Feng

doi:10.3389/fimmu.2021.781815

Cited by 46 publications

(28 citation statements)

References 123 publications

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“…It is noteworthy that miR-223 was first described as a regulator of myelopoietic differentiation in 2003, and to date, its multiple regulatory functions in the immune response are well documented. Abnormal expression of miR-223 is associated with multiple inflammatory diseases, including myocarditis, type II diabetes, acute lung injury, rheumatoid arthritis, and inflammatory bowel disease, as well as infectious diseases, including viral hepatitis, human immunodeficiency virus type 1 (HIV-1), and tuberculosis [ 113 ].…”

Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside the uterine cavity. It is estimated that it affects 10% of women of reproductive age. Its pathogenesis covers a wide range of abnormalities, including adhesion, proliferation, and cell signaling disturbances. It is associated with a significant deterioration in quality of life as a result of chronic pelvic pain and may also lead to infertility. One of the most serious complications of endometriosis is an ectopic pregnancy (EP). Currently, the exact mechanism explaining this phenomenon is unknown; therefore, there are no effective methods of prevention. It is assumed that the pathogenesis of EP is influenced by abnormalities in the contraction of the fallopian tube muscles, the mobility of the cilia, and in the fallopian microenvironment. Endometriosis can disrupt function on all three levels and thus contribute to the implantation of the embryo beyond the physiological site. This review takes into account aspects of the molecular mechanisms involved in the pathophysiology of endometriosis and EP, with particular emphasis on the similarities between them.

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Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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“…The decreased expression of miR-486 in the present study may lead to minimal inflammatory response at 14 dpi and 21 dpi of S. japonicum infection. miR-223 is one of the differentially expressed miRNAs identified in our study that has been shown to play a vital role in the immune response, regulating multiple processes from myeloid differentiation to neutrophil, macrophage, and DC function (61). The changes of miR-223-3p expression are linked to macrophage apoptosis (62) and play an essential role in maintaining the balance of innate immunity to avoid excess inflammation and tissue damage.…”

Section: Discussionmentioning

confidence: 86%

Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection

Giri

Li²,

Fang³

et al. 2022

Front. Immunol.

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Schistosomes undergo complicated migration in final hosts during infection, associated with differential immune responses. It has been shown that CD4+ T cells play critical roles in response to Schistosoma infections and accumulated documents have indicated that miRNAs tightly regulate T cell activity. However, miRNA profiles in host T cells associated with Schistosoma infection remain poorly characterized. Therefore, we undertook the study and systematically characterized T cell miRNA profiles from the livers and blood of S. japonicum infected C57BL/6J mice at 14- and 21-days post-infection. We observed 508 and 504 miRNAs, in which 264 miRNAs were co-detected in T cells isolated from blood and livers, respectively. The comparative analysis of T cell miRNAs from uninfected and infected C57BL/6J mice blood showed that miR-486b-5p/3p expression was significantly downregulated and linked to various T cell immune responses and miR-375-5p was highly upregulated, associated with Wnt signaling and pluripotency, Delta notch signaling pathways, etc. Whereas hepatic T cells showed miR-466b-3p, miR-486b-3p, miR-1969, and miR-375 were differentially expressed compared to the uninfected control. The different expressions of some miRNAs were further corroborated in isolated T cells from mice and in vitro cultured EL-4 cells treated with S. japonicum worm antigens by RT-qPCR and similar results were found. In addition, bioinformatics analysis combined with RT-qPCR validation of selected targets associated with the immune system and parasite-caused infectious disease showed a significant increase in the expression of Ctla4, Atg5, Hgf, Vcl and Arpc4 and a decreased expression of Fermt3, Pik3r1, Myd88, Nfkbie, Ppp1r12a, Ppp3r1, Nfyb, Atg12, Ube2n, Tyrobp, Cxcr4 and Tollip. Overall, these results unveil the comprehensive repertoire of T cell miRNAs during S. japonicum infection, suggesting that the circulatory (blood) and liver systems have distinct miRNAs landscapes that may be important for regulating T cell immune response. Altogether, our findings indicated a dynamic expression pattern of T cell miRNAs during the hepatic stages of S. japonicum infection.

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“…Again, a large number of vertebrate studies have reported the majority of these miRNAs as responding to viral and bacterial infections [ 13 , 24 , 25 , 26 , 50 ]. Some of the miRNAs well-described as pathogen-responsive from the LS materials included miR-23 (apoptosis, angiogenesis, muscle growth and regeneration [ 13 , 50 , 75 , 76 ]), miR-223 (regulation of inflammation in response to infection or muscle regeneration [ 13 , 50 , 77 , 78 ]), miR-125 and miR-146 (both annotated as viral as well as bacterial infection-responsive [ 13 , 32 , 50 ]) and miR-7132 (teleost-specific infection-responsive [ 25 ]). Two others of these gDE-miRNAs; miR-144 and miR-451 are expressed from a conserved miRNA gene cluster [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Expression Analysis of Moritella viscosa-Challenged Atlantic Salmon Identifies Disease-Responding Genes, MicroRNAs and Their Predicted Target Genes and Pathways

Ramberg

Krasnov

Colquhoun

et al. 2022

IJMS

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Moritella viscosa is a bacterial pathogen causing winter-ulcer disease in Atlantic salmon. The lesions on affected fish lead to increased mortality, decreased fish welfare, and inferior meat quality in farmed salmon. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation by guiding the miRNA-induced silencing complex to specific mRNA transcripts (target genes). The goal of this study was to identify miRNAs responding to Moritella viscosa in salmon by investigating miRNA expression in the head-kidney and the muscle/skin from lesion sites caused by the pathogen. Protein coding gene expression was investigated by microarray analysis in the same materials. Seventeen differentially expressed guide-miRNAs (gDE-miRNAs) were identified in the head-kidney, and thirty-nine in lesion sites, while the microarray analysis reproduced the differential expression signature of several thousand genes known as infection-responsive. In silico target prediction and enrichment analysis suggested that the gDE-miRNAs were predicted to target genes involved in immune responses, hemostasis, angiogenesis, stress responses, metabolism, cell growth, and apoptosis. The majority of the conserved gDE-miRNAs (e.g., miR-125, miR-132, miR-146, miR-152, miR-155, miR-223 and miR-2188) are known as infection-responsive in other vertebrates. Collectively, the findings indicate that gDE-miRNAs are important post-transcriptional gene regulators of the host response to bacterial infection.

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miR-223: An Immune Regulator in Infectious Disorders

Cited by 46 publications

References 123 publications

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection

Expression Analysis of Moritella viscosa-Challenged Atlantic Salmon Identifies Disease-Responding Genes, MicroRNAs and Their Predicted Target Genes and Pathways

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