miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition

Gan, Kang; Dong, Guan-hua; Wang, Ning; Zhu, Juanfang

doi:10.1016/j.diabres.2020.108121

Cited by 31 publications

(26 citation statements)

References 31 publications

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“…Combined with the negative effect of miR-186 on rat BMSC osteogenesis and the inhibitory action on the final myogenesis differentiation step by influencing myogenin translation, we deduce that miR-186 may be the driving factor in bone-muscle crosstalk during aging (Antoniou et al, 2014;. Furthermore, the increased miR-221 in aged-BMSC may also function in osteosarcopenia, because it was reported that ectopic overexpression of miR-221 in skeletal muscle satellite cells inhibits myotube formation and miR-221 was found to be a negative regulator of bone formation (Zhang et al, 2017;Liu B. et al, 2018;Gan et al, 2020). Xu R. et al (2018) reported aged BMSCs express high levels of miR-31a-5p leading to bias lineage fate of BMSCs to adipocytes through AT-rich sequence binding protein 2 (SATB2), aged BMSCs also release miR-31a-5p enriched EVs to its microenvironment, inducing increase in osteoclast number and function via the RhoA pathway.…”

Section: Ev-micrornas Of Bone Cells Engaged In Bone-muscle Crosstalkmentioning

confidence: 81%

Bone and Muscle Crosstalk in Aging

Hou

et al. 2020

Front. Cell Dev. Biol.

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Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term “osteosarcopenia” is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.

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Section: Ev-micrornas Of Bone Cells Engaged In Bone-muscle Crosstalkmentioning

confidence: 81%

Bone and Muscle Crosstalk in Aging

Hou

et al. 2020

Front. Cell Dev. Biol.

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“…Upregulating miR-7-5p inhibited the osteogenic differentiation of iPDLSCs and IGF-1R was identified as a direct target of miR-7-5p. Otherwise, Gan et al showed that miR-221-3p and miR-222-3p were up-regulated in the mandibles of diabetic rats and BMSCs cultured in high glucose condition [ 70 ]. Silencing of miR-221-3p or/ and miR-222-3p increased ALP activity and up-regulated osteoblast-related protein levels.…”

Section: Mechanisms Of Action Of the Gh/igfs/igfbps Axis On Dental And Bone Cellsmentioning

confidence: 99%

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Koffi

Doublier

Ricort

et al. 2021

Cells

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The GH/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH/IGF axis has also major pleiotropic endocrine and autocrine/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium). The present review re-examines and refines the expression of the elements of the GH/IGF axis in oral tissues and their in vivo and in vitro mechanisms of action in different mineralizing cell types of the dento-alveolar complex including ameloblasts, odontoblasts, pulp cells, cementoblasts, periodontal ligament cells, and jaw osteoblasts focusing on cell-specific activities. Together, these data emphasize the determinant role of the GH/IGF axis in physiological and pathological development, morphometry, and aging of the teeth, the periodontium, and oral bones in humans, rodents, and other vertebrates. These advancements in oral biology have elicited an enormous interest among investigators to translate the fundamental discoveries on the GH/IGF axis into innovative strategies for targeted oral tissue therapies with local treatments, associated or not with materials, for orthodontics and the repair and regeneration of the dento-alveolar complex and oral bones.

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“…MicroRNA-222 is located within an X-chromosome miRNA cluster, and the miR-222 sequence is highly conserved in pigs, humans, mice, cattle and other species, suggesting that it may be related to male fertility and sperm function and that the effect may be similar across species. As a key regulatory factor, miR-222 has also been reported to be involved in many other biological processes, such as cell proliferation, cell death, autophagy and apoptosis (Wang et al, 2015;Ding et al, 2018;Gan et al, 2020). In the present study, the results suggested that miR-222 can significantly improve sperm motility.…”

Section: Discussionsupporting

confidence: 54%

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miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition

Cited by 31 publications

References 31 publications

Bone and Muscle Crosstalk in Aging

Bone and Muscle Crosstalk in Aging

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

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