miR-219–5p Modulates Cell Growth of Papillary Thyroid Carcinoma by Targeting Estrogen Receptor α

Huang, Chen; Cai, Zhaogeng; Huang, Mingzhu; Mao, Chaoming; Zhang, Qifa; Lin, Yi Wen; Zhang, Xiaomei; Tang, Bi; Chen, Yuqing; Wang, Xiaojing; Qian, Zhi‐Gang; Ye, Lei; Peng, Yongde; Xu, Huanbai

doi:10.1210/jc.2014-2883

Cited by 52 publications

(45 citation statements)

References 26 publications

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“…Similarly, miR-291-5p was downregulated in PTC tumors, and the forced expression of the miR suppressed PTC cell proliferation and migration, as well as promoted apoptosis. This effect of miR-291-5p on PTC occurrence and behavior was possibly mediated by estrogen receptor a (ERa), its direct target (66). Among the top upregulated microRNAs in PTC, miR146b-5p plays a role in the cell proliferation and invasion and was shown to be transiently upregulated during epithelial-mesenchymal transition (EMT) (67).…”

Section: The Potential Of Micrornas In Thyroid Cancer Treatmentmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: MicroRNA in diagnostics and therapy of thyroid cancer

Wójcicka

Kolanowska

Jażdżewski

2016

European Journal of Endocrinology

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MicroRNAs, short non-coding regulators of the gene expression, are subjects of numerous investigations assessing their potential use in the diagnostics and management of human diseases. In this review, we focus on studies that analyze the utility of microRNAs as novel diagnostic and therapeutic tools in follicular cell-derived thyroid carcinomas. This very interesting and promising field brings new insight into future strategies for personalized medicine.

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Section: The Potential Of Micrornas In Thyroid Cancer Treatmentmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: MicroRNA in diagnostics and therapy of thyroid cancer

Wójcicka

Kolanowska

Jażdżewski

2016

European Journal of Endocrinology

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“…miR-219-5p, which has been widely investigated in several cancer processes (15)(16)(17)(18)34,35), was reported to be highly expressed in SCI (19). However, to date, the exact role of miR-219-5p in SCI remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…miR-219-5p has been identified as a tumor suppressor in several types of cancer, including colorectal cancer, gastric cancer, papillary thyroid carcinoma and hepatocellular (15)(16)(17)(18). In addition, a previous study has revealed a high expression of miR-219-5p in SCI (19); however, the exact role of miR-219-5p in SCI remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Protective role of microRNA‑219‑5p inhibitor against spinal cord injury via liver receptor homolog‑1/Wnt/β‑catenin signaling pathway regulation

Shen

2018

Exp Ther Med

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Abstract. The present study aimed to investigate the role of microRNA (miR)-219-5p in spinal cord injury (SCI) and to examine the underlying molecular mechanism. SCI rat and cell models were conducted in the current study, while reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the level of miR-219-5p in the SCI mice and neurons. Bioinformatics analysis was applied to predict the target genes of miR-219-5p, and dual-luciferase reporter assay was performed to verify the prediction. In addition, MTT assay and flow cytometry were conducted to determine the cell viability and cell apoptosis of the neurons, respectively. Western blot analysis was also performed to detect the expression of associated proteins. The study results demonstrated that miR-219-5p was highly expressed in SCI mice and neurons, and directly targets liver receptor homolog-1 (LRH-1). The neuron viability was significantly reduced by SCI, however, it was recovered upon transfection with an miR-219-5p inhibitor. Neuron apoptosis was notably induced by SCI and inhibited by miR-219-5p inhibition. The LRH-1/Wnt/β-catenin signaling pathway was also inhibited by SCI, while it was significantly enhanced by the miR-219-5p inhibitor. Furthermore, LRH-1 overexpression eliminated the effects of the miR-219-5p inhibitor on SCI. In conclusion, these data indicated that the miR-219-5p inhibitor served a protective role in SCI via regulating the LRH-1/Wnt/β-catenin signaling pathway.

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“…MiR-219-5p was downregulated in several solid tumors, such as hepatocellular carcinoma, glioblastoma and papillary thyroid carcinoma [26][27][28]. Several biological targets of miR-219-5p have also been identified recently.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-219-5p functions as a tumor suppressor partially by targeting platelet-derived growth factor receptor alpha in colorectal cancer

Gb¹,

Gn²,

Xiao³

et al. 2015

neo

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Platelet-derived growth factor receptor (PDGFR) signaling pathway was involved in the progress of colorectal cancer (CRC). By using the bioinformatic system online, we found that PDGFRα is a potential target of miR-219-5p. However, the expression pattern and underlying mechanisms of miR-219-5p had not been elucidated in CRC. Herein, we first evaluated the expression of miR-219-5p in tumor tissues by real-time polymerase chain reaction. Next, we confirmed that PDGFRα is the target of miR-219-5p by using luciferase report. And then, we investigated the biological functions of miR-219-5p in vitro in cell proliferation and apoptosis as well as cell cycle by gain and loss of function strategies. Data shown that miR-219-5p is down-regulated in CRC tissues compared with the corresponding matched normal tissues. PDGFRα was a direct target of miR-219-5p. Overexpression of miR-219-5p could inhibit cell proliferation, promote cell apoptosis and induce cell cycle arrest at the G1 phase. Furthermore, miR-219-5p suppressed the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway and downregulated G1 cell-cycle-related protein cyclin D1, cyclin-dependent kinase (CDK) 4, and CDK6. Taken together, our results demonstrate that miR-219-5p functions as a tumor suppressor partially by targeting PDGFRα in colorectal cancer.

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miR-219–5p Modulates Cell Growth of Papillary Thyroid Carcinoma by Targeting Estrogen Receptor α

Abstract: Our investigation identified miR-219-5p as a negative regulator of PTC development through targeting of ERα.

Cited by 52 publications

References 26 publications

MECHANISMS IN ENDOCRINOLOGY: MicroRNA in diagnostics and therapy of thyroid cancer

MECHANISMS IN ENDOCRINOLOGY: MicroRNA in diagnostics and therapy of thyroid cancer

Protective role of microRNA‑219‑5p inhibitor against spinal cord injury via liver receptor homolog‑1/Wnt/β‑catenin signaling pathway regulation

MicroRNA-219-5p functions as a tumor suppressor partially by targeting platelet-derived growth factor receptor alpha in colorectal cancer

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