miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β

MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expression

“…[22][23][24][25] In our study, a novel function and mechanism of miR-218 was found in its targeting of Mitf 3'-UTR and suppression of melanogenesis in a normal melanocyte model of murine melan-a cells. 26 A luciferase activity assay demonstrated the direct binding of miR-218 to the 3'-UTR of the Mitf gene (Fig.…”

Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis

“…Recent studies have demonstrated that miR-218 is downregulated in various types of cancer, including cervical cancer, gastric cancer, lung cancer, colon cancer, prostate cancer, and bladder cancer (Davidson et al, 2010;Song et al, 2010;Tie et al, 2010;Leite et al, 2011;Uesugi et al, 2011;Li et al, 2012a;Li et al, 2012b;Chiyomaru et al, 2012;He et al, 2012). However, the level of miR0218 expression, and its clinical significance in pancreatic cancer, remains to be investigated.…”

“…miR-218 functions as a tumor suppressor gene in various types of cancer, targeting multiple genes and regulating biological processes (Song et al, 2010;Tie et al, 2010;Uesugi et al, 2011;He et al, 2012;Li et al, 2012b;Yamamoto et al, 2013). Overexpression of miR-218 is known to inhibit cancer cell proliferation, invasion, and metastasis, and promote cancer cell apoptosis.…”

“…microRNA-218 (miR-218) is a vertebrate-specific miRNA that has been predicted and experimentally confirmed to play a crucial role in tumorigenesis and tumor progression by regulating the expression of potential targets (Hassan et al, 2012). Recent studies have indicated that miR-218 is down-regulated in various types of cancer, including cervical cancer, gastric cancer, lung cancer, colon cancer, prostate cancer, and bladder cancer (Davidson et al, 2010;Song et al, 2010;Tie et al, 2010;Uesugi et al, 2011;Leite et al, 2011;Li et al, 2012a,b;Chiyomaru et al, 2012;He et al, 2012). However, the level of expression of miR-218 and its clinical significance in pancreatic cancer has not been investigated.…”

MicroRNA-218 inhibits cell invasion and migration of pancreatic cancer via regulating ROBO1

“…14 Bmi1 and IKK-β were identified as functional targets of miRNA-218 correlated with tumor cell invasion and migration in glioma from two groups respectively. 15,18 In pancreatic cancer, UDP-glycosyltransferase-8 (UGT-8) was reported to be regulated by miRNA-218 and promote tumor metastasis. 19 It implied that miRNA-218 was related to the progression of pancreatic cancer, However, UGT-8 was not the only functional target gene of miRNA-218 involved in metastasis of pancreatic cancer.…”