mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27

Feng, Zhuoying; Zhang, Luping; Zhou, Junchen; Zhou, Shuai; Li, Li; Guo, Xijing; Feng, Guoying; Ma, Ze; Huang, Wenhua; Huang, Fei

doi:10.18632/oncotarget.13850

Cited by 20 publications

(19 citation statements)

References 41 publications

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“…Qiu L et al reported that CDC27 induces metastasis and invasion in colorectal cancer via the promotion of epithelial-to-mesenchymal transition [15]. Feng Z et al also demonstrated that Cdc27 is a target for glioblastomas growth, invasion and drug resistance [16]. Our findings showed that the expression levels of E-cadherin were dramatically increased and that the expression levels of Snail and Twist were correspondingly significantly decreased in the shCDC27 cells.…”

Section: Discussionsupporting

confidence: 61%

“…Besides, increasing reports revealed that CDC27 expression was deregulated in varies of cancers, including breast cancer, and colorectal cancer [13][14][15]. Feng Z et al reported that mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27, and that CDC27 expression may be a significant indicator [16]. Accumulating evidence indicates CDC27 may be involved in the invasion and metastasis of gastric cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition

Xin

Ning

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Lymph node metastasis is the primary cause of cancer-related death among patients with gastric cancer (GC), and cell division cycle 27 (CDC27) promotes the metastasis and epithelial-mesenchymal transition in many cancers. Till now, the mechanisms underlying CDC27-induced the epithelial-mesenchymal transition (EMT) of GC are still unclear. Methods: We analyzed the expression levels of CDC27 and EMT-related biomarkers using immunohistochemistry and Western blot in 60 cases of GC tissues, and then GC cells with CDC27 shRNAs or plasmids were subjected to in vitro and in vivo assays, including CCK-8, wound healing and transwell assays. Results: The CDC27 expression was obviously increased in GC tissues, and significantly correlates with EMT-related biomarkers, lymph node metastasis and poor 5-year overall survival. Additionally, in vitro and in vivo assays demonstrated that silencing of CDC27 expression effectively inhibited GC cell proliferation, invasion and metastasis. Conversely, CDC27 overexpression led to the opposite results. Finally, we demonstrated that Twist shRNA inhibited CDC27-meditated invasion and EMT of GC cells. Conclusion: CDC27 facilitates gastric cancer cell proliferation, invasion and metastasis via Twist-induced EMT; thus, this study offered a new therapy method for GC patients.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition

Xin

Ning

Zhang

et al. 2018

Cell Physiol Biochem

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“…In recent years, several studies have reported that CDC27 can facilitate cell proliferation, migration and invasion in some types of cancers (23)(24)(25). Nevertheless, few studies indicated the opposite influence of CDC27 on cell functions and patients' survival analysis (26,27). The expression and effect of CDC27 in lymphoma has not been reported or clarified.…”

Section: Discussionmentioning

confidence: 99%

CDC27 Promotes Tumor Progression and Affects PD-L1 Expression in T-Cell Lymphoblastic Lymphoma

Song

et al. 2020

Front. Oncol.

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T-lymphoblastic lymphoma (T-LBL) is a rare hematological malignancy with highly aggressive, unique clinical manifestations, and poor prognosis. Cell division cycle 27 (CDC27) was previously reported to be a significant subunit of the anaphase-promoting complex/cyclosome. However, the specific functions and relevant mechanisms of CDC27 in T-LBL remain unknown. Through immunohistochemistry staining, we identified that CDC27 was overexpressed in T-LBL tissues and related to tumor progression and poor survival. Functional experiments demonstrated that CDC27 promoted proliferation in vivo and in vitro. Further experiment suggested the role of CDC27 in facilitating G1/S transition and promoting the expression of Cyclin D1 and CDK4. Then the effect of CDC27 in inhibiting apoptosis was also identified. Furthermore, we found a positive correlation between the expression of CDC27 and Programmed death ligand-1 (PD-L1) by immunohistochemistry staining. The interaction between CDC27 and PD-L1 was also proved by western blot, luciferase gene reporter assay and immunofluorescence. Taken together, our results showed that CDC27 contributes to T-LBL progression and there is a positive correlation between PD-L1 and CDC27, which offers novel perspectives for future studies on targeting CDC27 in T-LBL.

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“…However, miR-218–5p has been reported to function as an oncogenic miRNA in glioma [54], suggesting that the pro- and anti-cancer roles of miR-218–5p are tumor-type dependent. In addition, miR-218–5p has been found to be downregulated in PCa, which promoted the development, progression, and castration-resistance of PCa via varying mechanisms [13-16].…”

Section: Discussionmentioning

confidence: 99%

Decreased miR-218–5p Levels as a Serum Biomarker in Bone Metastasis of Prostate Cancer

Peng¹,

Chen

Wang

et al. 2019

Oncol Res Treat

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Background: miR-218–5p is an extensively studied microRNA (miRNA) in prostate cancer (PCa). However, the clinical significance and biological role of miR-218–5p in bone metastasis of PCa remain unclear. Materials and Methods: miR-218–5p expression was evaluated in 38 bone metastatic and 115 non-bone metastatic PCa tissues and serum samples. Clinical correlation of miR-218–5p expression with clinicopathological characteristics was analyzed. The biological roles of miR-218–5p in bone metastasis of PCa were investigated in vitro by invasion and migration assays. Bioinformatics analysis, real-time polymerase chain reaction, western blot, and luciferase reporter assay were applied to discern and examine the relationship between miR-218–5p and its potential targets. Results: miR-218–5p expression was reduced in bone metastatic PCa tissue and serum samples, which positively correlated with poor clinicopathological characteristics and bone metastasis-free survival in PCa patients. Upregulating miR-218–5p repressed PCa cell invasion and migration. Furthermore, miR-218–5p inhibited NF-κB signaling via simultaneously targeting TRAF1, TRAF2, and TRAF5, which suppressed the invasion and migration abilities of PCa cells. ROC curve analysis of miR-218–5p in the serum of PCa patients exhibited an area under the curve of 0.86 (95% confidence interval 0.80–0.92, p < 0.001). Conclusion: Our findings indicate that miR-218–5p might represent a novel serum biomarker for bone metastasis of PCa.

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mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27

Cited by 20 publications

References 41 publications

CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition

CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition

CDC27 Promotes Tumor Progression and Affects PD-L1 Expression in T-Cell Lymphoblastic Lymphoma

Decreased miR-218–5p Levels as a Serum Biomarker in Bone Metastasis of Prostate Cancer

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