MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting<i>SIRT1</i>in Osteosarcoma

He, Shaoxuan; Wang, Zhihua; Tang, Haojun; Dong, Junjie; Qu, Yongzhou; Lv, Jia

doi:10.1089/cbr.2017.2394

Cited by 26 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…lncRNAs regulate cellular processes through diverse molecular mechanisms in various diseases (19); specifically, lncRNAs function as ceRNAs via competitively binding to microRNAs to regulate cellular functions (20). The present study found that LINC01268 could serve as a ceRNA for miR-217, which has been previously regarded as a tumor suppressor in the progression of osteosarcoma and ovarian cancer (21,22). Besides, miR-217 suppressed TGF-b1-induced proliferation and migration of airway smooth muscle cells through targeting ZEB1 (23).…”

Section: Discussionmentioning

confidence: 51%

Long non-coding RNA LINC01268 promotes cell growth and inhibits cell apoptosis by modulating miR-217/SOS1 axis in acute myeloid leukemia

Chen

Nie

et al. 2020

Braz J Med Biol Res

View full text Add to dashboard Cite

The aim of this study was to evaluate the pathogenic role of newly identified long non-coding (lnc)-RNA LINCO1268 in acute myeloid leukemia (AML), and investigate its therapeutic potential. The expression level of LINC01268 in AML was measured by quantitative PCR (qPCR). The viability, cell cycle progression, and apoptosis of AML cells were measured by CCK-8 assay and flow cytometry, respectively. The interaction between LINC01268 and miR-217 were predicted by the miRDB website, and then verified by luciferase reporter assay and RNA immunoprecipitation (RIP) assay. The relationship between miR-217 and SOS1 was predicted by TargetScan website, and verified by luciferase reporter assay. LINC01268 was significantly upregulated by 1.6 fold in bone marrow samples of AML patients, which was associated with poor prognosis. LINC01268 was also significantly upregulated in AML cells. LINC01268 knockdown inhibited viability and cell cycle progression but promoted apoptosis of AML cells. Furthermore, LINC01268 functioned as a ceRNA via competitively binding to miR-217, and SOS1 was identified as a target of miR-217. Moreover, LINC01268 positively regulated SOS1 expression to promote AML cell viability and cell cycle progression but inhibited apoptosis via sponging miR-217. LINC01268 promoted cell growth and inhibited cell apoptosis through modulating miR-217/SOS1 axis in AML. This study offers a novel molecular mechanism for a better understanding of the pathology of AML. LINC01268 could be considered as a potential biomarker for the therapy and diagnosis of AML.

show abstract

Section: Discussionmentioning

confidence: 51%

Long non-coding RNA LINC01268 promotes cell growth and inhibits cell apoptosis by modulating miR-217/SOS1 axis in acute myeloid leukemia

Chen

Nie

et al. 2020

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…osteosarcoma (He et al, 2019). Jiang B reported that miR-217 inhibited tumor-induced M2 macrophage polarization by targeting IL-6 and regulating the JAK3/STAT3 signaling pathway, probably providing an underlying therapeutic target in the treatment of ovarian cancer (Jiang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Circ-ZDHHC5 Accelerates Esophageal Squamous Cell Carcinoma Progression in vitro via miR-217/ZEB1 Axis

Wang

Yang

Fan

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Circular RNA (circRNA) exhibits a covalently closed circular conformation and is structurally stable. Nevertheless, the precise effects exerted by circRNA in esophageal squamous cell carcinoma (ESCC) remains uncertain. circRNA was ascertained by a human circRNA array study and was confirmed by the quantification of reverse transcriptase polymerase reactions. A luciferase reporter, fluorescence in situ hybridization experiment was exploited to explore the interaction between circ-ZDHHC5 and miR-217. The function of circ-ZDHHC5 was determined by siRNA-mediated knockout of circ-ZDHHC5 in in vitro proliferation, migration, and invasion. circ-ZDHHC5, rather than linear ZDHHC5 mRNA, rose in the tissues of patients with ESCC, plasma, and ESCC cell lines in comparison with normal controls. Knockdown of circ-ZDHHC5 inhibited tumorigenesis in ESCC cells, and the co-transfection of si-circ-ZDHHC5 and miR-217 mimics further enhanced the above effect. Noticeably, the present study showed that circ-ZDHHC5 was an miR-217 sponge that modulated the expression of zinc finger E-box binding homeobox 1 (ZEB1), further facilitating ESCC tumorigenesis. As revealed by this study, circ-ZDHHC5 can act as a new potential circular biomarker for detecting ESCC. It provides a novel perceptivity for the treatment of ESCC suggesting that circ-ZDHHC5 could impact on ESCC progression by sponging miR-217 with ZEB1.

show abstract

“…MiRNA-217 is a tumor suppressor miRNA targeting several oncogenes in different cell type (20,21). MiR-217 could serve as a tumor suppressor which can inhibit tumor growth (22).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of Serum miR-217 Level in Osteosarcoma Patients

Jia

Jin

Ren

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: MicroRNA (miR)-217 is a tumor suppressor significantly associated with osteosarcoma. We try to evaluate serum levels miR-217 in osteosarcoma patients and evaluate its prognostic significance.Methods: A total of 163 consecutive osteosarcoma patients and 96 healthy participates were enrolled. Serum miR-217 levels were evaluated by using real-time quantitative reverse transcription polymerase chain reactions (RT-PCR). The association between serum miR-217 level and survival outcomes was evaluated by univariate and multivariate analysis. Results: Serum miR-217 levels in osteosarcoma patients was significantly lower than healthy volunteers (P<0.05). Low serum miR-217 was significantly related to advanced cancer and metastasis (both P<0.05). Moreover, patients with a low serum miR-217 had a poorer overall survival than those with a high serum miR-217 levels (P<0.05). Serum miR-217 level also been showed as independent risk factor for osteosarcoma in multivariate analysis (HR, 0.42; 95%CI: 0.12–0.98; p<0.01). Conclusions: Serum miR-217 levels was significantly downregulated in osteosarcoma patients and remarkably associated with poor prognosis, indicating that serum miR-217 might serve as a useful diagnostic and prognostic indictor for osteosarcoma.

show abstract

MiR-217 Inhibits Proliferation, Migration, and Invasion by TargetingSIRT1in Osteosarcoma

Cited by 26 publications

References 30 publications

Long non-coding RNA LINC01268 promotes cell growth and inhibits cell apoptosis by modulating miR-217/SOS1 axis in acute myeloid leukemia

Long non-coding RNA LINC01268 promotes cell growth and inhibits cell apoptosis by modulating miR-217/SOS1 axis in acute myeloid leukemia

Circ-ZDHHC5 Accelerates Esophageal Squamous Cell Carcinoma Progression in vitro via miR-217/ZEB1 Axis

Prognostic value of Serum miR-217 Level in Osteosarcoma Patients

Contact Info

Product

Resources

About