MiR-215 modulates gastric cancer cell proliferation by targeting RB1

Deng, Yujie; Zhenxia, Huang; Xu, Yanjun; Jin, Juan; Zhuo, Wei; Zhang, Cheng; Zhang, Xuting; Shen, Minhong; Yan, Xin; Wang, Liangjing; Wang, Xiaojia; Kang, Yibin; Si, Jianmin; Zhou, Tian

doi:10.1016/j.canlet.2013.08.033

Cited by 83 publications

(62 citation statements)

References 54 publications

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“…With regard to miR-215, several targets have been confirmed in previous studies including protein tyrosine phosphatase receptor type T (PTPRT) , thymidylate synthase (TS) (Song et al, 2010), dihydrofolate reductase (DHFR) (Song et al, 2010), retinoblastoma tumor suppressor gene 1 (RB1) (Deng et al, 2014), activated leukocyte cell adhesion molecule (ALCAM) (Jin et al, 2011), and activin receptor type 2B (ACVR2B) (Senanayake et al, 2012). ZEB2, as a tumor-promoting gene, has been found to be upregulated in different tumor types, and identified as a target gene of a number of miRs.…”

Section: Discussionmentioning

confidence: 89%

“…In cervical cancer, miR-215 expression was significantly higher in the cancerous tissues of patients with lymph node metastasis, advanced FIGO stage, and poor survival . In gastric cancer, high miR-215 expression showed significant correlation with tumor invasion and UICC stage (Deng et al, 2014). Functionally, miR-215 was able to promote the proliferation of hepatoma cells and gastric cancer cells (Deng et al, 2014;.…”

Section: Discussionmentioning

confidence: 95%

“…In gastric cancer, high miR-215 expression showed significant correlation with tumor invasion and UICC stage (Deng et al, 2014). Functionally, miR-215 was able to promote the proliferation of hepatoma cells and gastric cancer cells (Deng et al, 2014;. Anti-miR-215 remarkably inhibited the tumor growth of hepatoma cells in nude mice .…”

Section: Discussionmentioning

confidence: 96%

“…Dysregulation of miR expression has frequently been reported to be closely associated with tumor initiation, promotion, and progression. miR-215 is upregulated in cervical cancer , hepatocellular carcinoma , gastric cancer (Deng et al, 2014), and prostate cancer (Walter et al, 2013), and it acts as a potential oncogene in these tumors. On the contrary, the expression of miR-215 was found to be significantly decreased in esophageal adenocarcinoma (Wijnhoven et al, 2010), colon cancer (Karaayvaz et al, 2011), and renal cell carcinoma (RCC) (White et al, 2011), where it acts as a candidate tumor suppressor.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer

Qw¹,

Zhou²,

F³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. It has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression. However, its expression and function in pancreatic cancer is still unclear. The aim of this study was to explore the effects of miR-215 on pancreatic cancer formation and progression. Using quantitative RT-PCR, we detected miR-215 expression in pancreatic cancer cell lines and primary tumor tissues. The association of miR-215 expression with clinicopathological factors and prognosis was also analyzed. We then observed the effects of miR-215 on the biological behavior of pancreatic cancer cells. Lastly, the potential regulatory function of miR-215 on ZEB2 expression was investigated. miR-215 expression levels were significantly downregulated in pancreatic cancer samples and cell lines. Decreased miR-215 expression was significantly associated with large tumor size, advanced TNM stage, lymph node metastasis, vessel invasion, and lower overall survival. Multivariate regression analysis corroborated that downregulation of miR-215 was an independent unfavorable prognostic factor. Overexpression of miR-215 inhibited pancreatic cancer cell 16133-16145 (2015) proliferation, invasion, and migration; promoted cell apoptosis in vitro; and suppressed tumorigenicity in vivo. Further, ZEB2 was confirmed as a direct target of miR-215 by using a luciferase reporter assay. These findings indicate that miR-215 may act as a tumor suppressor in pancreatic cancer cells, and could serve as a novel therapeutic target for miR-based therapy.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer

Qw¹,

Zhou²,

F³

et al. 2015

Genet. Mol. Res.

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“…Primarily, RB1 restricts the expression of genes that are necessary for cell proliferation via suppressing transcription of E2F targets [11]. Moreover, RB1 was down-regulated in gastric cancer [12,13].…”

Section: Research Papermentioning

confidence: 99%

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

Zhou

Shi

et al. 2018

Oncotarget

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A five‐miRNA panel in plasma was identified for breast cancer diagnosis

Zou

Xia

et al. 2019

Cancer Medicine

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Breast cancer (BC) is one of the most common cancers in females. Since early detection can bring prognosis benefit, discovery of novel noninvasive biomarkers for BC diagnosis is in urgent need. In this four‐phase study, we profiled miRNA expression in plasma samples from a total of 257 BC patients and 257 normal controls (NCs). Exiqon miRNA qPCR panel was used to select candidate miRNAs in the screening phase which were further analyzed using qRT‐PCR in the following training, testing and external validation phases. Finally, we identified five plasma miRNAs (let‐7b‐5p, miR‐122‐5p, miR‐146b‐5p, miR‐210‐3p and miR‐215‐5p) whose expression levels were significantly different between BC patients and NCs. A 5‐miRNA panel in plasma with high sensitivity and specificity was then constructed to detect BC. The areas under the receiver‐operating characteristic curves (AUCs) of the panel were 0.683, 0.966, 0.978 for the training, testing and external validation sets, respectively. Expression of the identified miRNAs was further analyzed among 32 pairs of BC tissue and the adjacent normal tissue samples as well as plasma‐derived exosome samples from 32 BC patients vs 32 NCs. Let‐7b‐5p was contrarily down‐regulated in BC tissue. In exosomes samples, only miR‐122‐5p was significantly up‐regulated as in plasma for BC patients. In conclusion, we identified a 5‐miRNA plasma panel (let‐7b‐5p, miR‐122‐5p, miR‐146b‐5p, miR‐210‐3p and miR‐215‐5p) that could serve as a promising biomarker for BC detection.

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MiR-215 modulates gastric cancer cell proliferation by targeting RB1

Cited by 83 publications

References 54 publications

MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer

MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

A five‐miRNA panel in plasma was identified for breast cancer diagnosis

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