miR-214 aggravates oxidative stress in thalassemic erythroid cells by targeting ATF4
Tipparat Penglong,
Apisara Saensuwanna,
Husanai Jantapaso
et al.
Abstract:Oxidative damage to erythroid cells plays a key role in the pathogenesis of thalassemia. The oxidative stress in thalassemia is potentiated by heme, nonheme iron, and free iron produced by the Fenton reaction, due to degradation of the unstable hemoglobin and iron overload. In addition, the levels of antioxidant enzymes and molecules are significantly decreased in erythrocytes in α- and β-thalassemia. The control of oxidative stress in red blood cells (RBCs) is known to be mediated by microRNAs (miRNAs). In er… Show more
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