miR-214–5p/C1QTNF1 axis enhances PCV2 replication through promoting autophagy by targeting AKT/mTOR signaling pathway

Cao, Yue; Jing, Pengfei; Yu, Luchen; Wu, Zhengchang; Gao, Song; Bao, Wenbin

doi:10.1016/j.virusres.2022.198990

Cited by 3 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiRNA is a newly discovered gene regulator in recent years [ 31 ]. MiRNA is implicated in the mediation of cell proliferation, differentiation, apoptosis and other biological processes by specifically downregulating the post-transcriptional expression of target genes [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

MiR-483-5p downregulation alleviates ox-LDL induced endothelial cell injury in atherosclerosis

Zhu,

Liang,

Gao

et al. 2023

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background In light of the abnormal expression of microRNA (miR-483-5p) in patients with atherosclerosis (AS), its role in vascular endothelial cell injury was explored. And the mechanisms related to autophagy were also elucidated. Methods Human umbilical vein endothelial cells (HUVECs) were given 100 mg/L ox-LDL to induce endothelial injury. Cell transfection was done to regulate miR-483-5p levels. Cell viability and apoptosis were detected. qRT-PCR was employed for the mRNA levels’ detection. Results Autophagic flux impairment of HUVECs was detected after ox-LDL treatment, along with the upregulation of miR-483-5p. Ox-LDL inhibited cell viability and promoted cell apoptosis, but these influences were changed by miR-483-5p downregulation. MiR-483-5p downregulation decreased the mRNA levels of IL-1β, IL-6, ICAM-1 and VCAM-1. 3-MA, the autophagy inhibitor, reversed the beneficial role of miR-483-5p downregulation in ox-LDL-induced HUVECs’ injury. TIMP2 acts as a target gene of miR-483-5p, and was downregulated in HUVEC models. Conclusion MiR-483-5p downregulation alleviated ox-LDL-induced endothelial injury via activating autophagy, this might be related to TIMP2.

show abstract

Section: Discussionmentioning

confidence: 99%

MiR-483-5p downregulation alleviates ox-LDL induced endothelial cell injury in atherosclerosis

Zhu,

Liang,

Gao

et al. 2023

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that knockout of C1QTNF1 inhibits cell proliferation and invasion as well as tumor growth by generating C1QTNF1 knockout human lung cancer and human colon cancer cell lines ( Park et al, 2022 ). Meanwhile, C1QTNF1 has also been found to be widely involved in the regulation of a variety of inflammatory responses, such as the association of C1QTNF1 levels with coronary artery disease ( Shen et al, 2019 ); C1QTNF1 suppressed porcine circovirus type 2 ( PCV2 ) replication ( Cao et al, 2023 ). In addition, body mass index and glucose levels are positively associated with C1QTNF1 ( Kim et al, 2006 ; Xin et al, 2014 ), and its impact on chondrocyte proliferation and maturation, aldosterone synthesis ( Jeon et al, 2008 ; Akiyama et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Potential regulator of meat quality in geese: C1QTNF1 implications on cell proliferation and muscle growth

Ni,

Zhang,

et al. 2024

Poultry Science

View full text Add to dashboard Cite

miR-22a targets p62/SQSTM1 to negatively affect autophagy and disease resistance of grass carp (Ctenopharyngodon idella)

Yu,

Xie,

Chen

et al. 2023

Fish & Shellfish Immunology

View full text Add to dashboard Cite

miR-214–5p/C1QTNF1 axis enhances PCV2 replication through promoting autophagy by targeting AKT/mTOR signaling pathway

Cited by 3 publications

References 44 publications

MiR-483-5p downregulation alleviates ox-LDL induced endothelial cell injury in atherosclerosis

MiR-483-5p downregulation alleviates ox-LDL induced endothelial cell injury in atherosclerosis

Potential regulator of meat quality in geese: C1QTNF1 implications on cell proliferation and muscle growth

miR-22a targets p62/SQSTM1 to negatively affect autophagy and disease resistance of grass carp (Ctenopharyngodon idella)

Contact Info

Product

Resources

About