MiR-20a, a novel promising biomarker to predict prognosis in human cancer: a meta-analysis

Abstract

BackgroundRecently, microRNA-20a (miR-20a) has been reported to influence the clinical features and may have prognostic value in human cancers. The present meta-analysis assessed the prognostic role of miR-20a in various carcinomas.MethodsLiterature searches of seven electronic databases were performed for eligible articles of the prognostic role of miR-20a in human cancers. Hazard ratios (HR) for overall survival (OS), disease free survival (DFS), progression-free survival (PFS) as well as their 95% confidence intervals (95%CIs) were used to assess the influence of miR-20a expression on patient prognosis. Odds ratio (OR) and 95%CIs were applied to evaluate the correlation between miR-20a expression and clinicopathological characteristics.ResultsBased on the OS analyzed by log rank tests, there was a significant association between miR-20a levels and OS by fixed effects model. By subgroup analyses, the significance was also observed in the studies of specimen derived from blood and gastrointestinal cancer group. The independent prognostic role of miR-20a expression for the OS was observed significantly by fixed effects model. In addition, we observed significant association between miR-20a expression levels and DFS of log rank tests, DFS of cox regression. Significant relation of gender/differentiation and the expression level of miR-20a was identified.ConclusionsBase on the findings, the elevated miR-20a expression level is related to poor prognosis of gastrointestinal cancer patients. As for other types of carcinomas, the results are still not stable and more studies are required to further identify miR-20a prognostic values. In addition, miR-20a expression level is relatively higher in women than that in men, and increased miR-20a expression level is linked to poor tumor differentiation.

LncRNA MALAT1 regulates inflammatory cytokine production in lipopolysaccharide‐stimulated human gingival fibroblasts through sponging miR‐20a and activating TLR4 pathway

“…MiR‐20a locates in human chromosome 13q31‐q32 and is involved in the regulation of inflammatory responses . In human alveolar epithelial cell line A549, LPS stimulation increases the level of miR‐20a, and miR‐20a mimic increases the levels of IL‐6, TNF‐α, C‐reactive protein, IκBα, and p‐NF‐κB .…”

“…12,17,18 Also, lncRNAs may act as the MiR-20a locates in human chromosome 13q31-q32 and is involved in the regulation of inflammatory responses. [19][20][21][22] In human alveolar epithelial cell line A549, LPS stimulation increases the level of miR-20a, and miR-20a mimic increases the levels of IL-6, TNF-α, C-reactive protein, IκBα, and p-NF-κB. 22 From our results, the expression of miR-20a was reduced by LPS stimulation; however, overexpression of miR-20a inhibited the level of TLR4 and inflammatory cytokines IL-6 and IL-8, which is consistent to Philippe et al's research.…”

A preliminary model of football-related neural stress that integrates metabolomics with transcriptomics and virtual reality

“…Previous studies have reported increased levels of neuroinflammatory miRNAs prior to contact play with minimal change in miRNA levels across season ( Chen et al., 2020 ; Papa et al., 2019 ). MiRNAs in this panel have known roles in cancer progression ( Che et al., 2019 ; Hsu et al., 2016 ; Huang et al., 2018 ; Kobayashi et al., 2012 ; Kohram et al., 2018 ; Li et al., 2011 , 2016 ; Ling et al., 2019 ; Lv et al., 2018 ; Mogilyansky and Rigoutsos, 2013 ), inflammation and inflammatory diseases ( Paraskevi et al., 2012 ; Reddycherla et al., 2015 ; Wu et al., 2011 ; Zheng et al., 2015 ), and neurodegeneration ( Basak et al, 2016 ; Denk et al., 2015 ; Jee et al., 2012b ; Khoo et al., 2012 ; Liu et al., 2017 ). These miRNAs have also been shown to target genes that have neuroinflammatory functions and roles in diseases with neuroinflammatory pathophysiology ( Cao et al., 2017 ; Lisha Chang et al., 2020 ; Gao et al., 2019 ; Gayen et al., 2020 ; Hu et al., 2019 ; Jee et al., 2012a ; Jiang et al., 2018 ; Ma et al., 2014 ; Mao et al., 2019 ; Martinez and Peplow, 2017 ; Naqvi et al., 2016 ; Navaderi et al., 2019 ; Peng and Ying, 2014 ; Shi et al., 2018 ; Sinha et al., 2012 ; Sujith et al., 2018 ; Thangaraj et al., 2021 ; Wang et al., 2021 ; Xie et al., 2020 ; Yang et al., 2018 ; Yao et al., 2014 ; Zhao et al., 2017 ; Zhong et al., 2021 ; Zhou et al., 2021 ).…”

Overexpression of miR-20a-5p in Tumor Epithelium Is an Independent Negative Prognostic Indicator in Prostate Cancer—A Multi-Institutional Study

“…Some systematic reviews have also suggested circulating miR-20a as a diagnostic biomarker for NSCLC [35,36]. Meta-analyses focusing on gastrointestinal cancers have found high miR-20a expression (tissue and circulation) associated with poor prognosis [34,[37][38][39][40]. In nasopharyngeal cancer, a systematic review found upregulated miR-20a in the circulation associated with poor prognosis [41].…”