miR-205-5p inhibits thymic epithelial cell proliferation via FA2H-TFAP2A feedback regulation in age-associated thymus involution

Gong, Bishuang; Wang, Xintong; Li, Boning; Liu, Ying; Ling, Rui; Zhang, Kaizhao; Li, Bingxin; Ma, Yue; Li, Yugu

doi:10.1016/j.molimm.2020.04.011

Cited by 13 publications

(11 citation statements)

References 70 publications

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Section: Discussionmentioning

confidence: 96%

“…Fra1 is upregulated in MG than that in normal thymus, and researchers have confirmed the overexpression of Fra1 in medulla thymic epithelial cells, which destroys the secretion of inflammatory cytokines and affects disease progression [ 29 ]. MiR-205-5p negatively control thymic involution by interacting with TFAP2A [ 30 ]. There was a strong correlation between these genes and immune status of thymus, while there was little research on thymoma induced MG which should be paid more attention.…”

Section: Discussionmentioning

confidence: 99%

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Two types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma

et al. 2021

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Thymoma is the most common primary mass in anterior mediastinum. Although associated with low malignancy, it is often accompanied by myasthenia gravis resulting in poor prognosis. Due to the dual factors of tumor immune tolerance and autoimmune reaction, it is urgent to understand the immune status of MG with thymoma. In this study, RNA sequencing data were obtained from the TCGA and GEO cohorts to identify differentially expressed messenger RNAs and infiltrated immune cells. A total of 121 samples in TCGA and 43 samples in GEO were screened out. The infiltrated immune cells were identified by CIBERSORT, in which Tfh cells and activated DC cells were abnormal in thymoma patients. The differently expressed genes were performed by package LIMMA. The functional characteristics of differently expression genes were analyzed by GO and KEGG; one GO and seven KEGG pathways were both found in both TCGA and GEO cohorts. Meanwhile, 27 common differently expressed genes were obtained and were displayed by a Venn diagram. The TRRUST was used to screen the hub genes for the common 27 different genes and 6 genes were found. Then, PPI networks were constructed. Subsequently, the relationship between SCNAs of common genes and related immune cells tested by TIMER. Kaplan-Meier plots, ROC curve and Cox's expression model for immune infiltration and hub genes were also tested. In conclusion, we found that two types of immune infiltrated cells and six hub genes can predict the occurrence of myasthenia gravis in thymoma patients.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Two types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma

et al. 2021

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“…Thymic epithelial cells (TECs) are essential regulators of T cell development and selection. miR-205-5p inhibits thymic epithelial cell proliferation via FA2H-TFAP2A feedback regulation in age-associated thymus involution ( Gong et al, 2020 ). In glioma cells, miR-205-5p regulates TGF-β1 by targeting SMAD2, thereby influencing the immune response of TGF-β1 in tumors ( Flavell et al, 2010 ; Meulmeester and Ten Dijke 2011 ; Duan and Chen 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Construction of the miRNA-mRNA Regulatory Networks and Explore Their Role in the Development of Lung Squamous Cell Carcinoma

Fan

Zou

Liu

et al. 2022

Front. Mol. Biosci.

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Purpose: MicroRNA (miRNA) binds to target mRNA and inhibit post-transcriptional gene expression. It plays an essential role in regulating gene expression, cell cycle, and biological development. This study aims to identify potential miRNA-mRNA regulatory networks that contribute to the pathogenesis of lung squamous cell carcinoma (LUSC).Patients and Methods: MiRNA microarray and RNA-Seq datasets were obtained from the gene expression omnibus (GEO) databases, the cancer genome atlas (TCGA), miRcancer, and dbDEMC. The GEO2R tool, “limma” and “DEseq” R packages were used to perform differential expression analysis. Gene enrichment analysis was conducted using the DAVID, DIANA, and Hiplot tools. The miRNA-mRNA regulatory networks were screened from the experimentally validated miRNA-target interactions databases (miRTarBase and TarBase). External validation was carried out in 30 pairs of LUSC tissues by Real-Time Quantitative Reverse Transcription PCR (qRT-PCR). Receiver operating characteristic curve (ROC) and decision curve analysis (DCA) were conducted to evaluate the diagnostic value. Clinical, survival and phenotypic analysis of miRNA-mRNA regulatory networks were further explored.Results: We screened 5 miRNA and 10 mRNA expression datasets from GEO and identified 7 DE-miRNAs and 270 DE-mRNAs. After databases screening and correlation analysis, four pairs of miRNA-mRNA regulatory networks were screened out. The miRNA-mRNA network of miR-205-5p (up) and PTPRM (down) was validated in 30 pairs of LUSC tissues. MiR-205-5p and PTPRM have good diagnostic efficacy and are expressed differently in different clinical features and are related to tumor immunity.Conclusion: The research identified a potential miRNA-mRNA regulatory network, providing a new way to explore the genesis and development of LUSC.

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“…a recent study reported that mir-122 was upregulated in oBs originating from ovariectomized rats, and further investigation revealed that mir-122 could inhibit oB proliferation and differentiation by activating the JnK pathway and suppressing PcP4 expression (13). recent studies have shown that mir-205-5p is involved in regulating the proliferation of various cells, such as retinal pigment epithelial cells, thymic epithelial cells and pancreatic cancer cells (92)(93)(94). recently, Huang et al (95) revealed that mir-205-5p expression was increased in samples from patients with osteoporosis and then was gradually downregulated during osteogenic differentiation.…”

Section: Mechanisms By Which Ncrnas Regulate Obs In Osteoporosismentioning

confidence: 99%

Effects of miRNAs, lncRNAs and circRNAs on osteoporosis as regulatory factors of bone homeostasis (Review)

Han

Tan

et al. 2021

Mol Med Rep

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osteoporosis is a common metabolic bone disorder typically characterized by decreased bone mass and an increased risk of fracture. at present, the detailed molecular mechanism underlying the development of osteoporosis remains to be elucidated. accumulating evidence shows that non-coding (nc)rnas, such as micrornas (mirnas), long ncrnas (lncrnas) and circular rnas (circRNAs), play significant roles in osteoporosis through the post-transcriptional regulation of gene expression as regulatory factors. Previous studies have demonstrated that ncrnas participate in maintaining bone homeostasis by regulating physiological and developmental processes in osteoblasts, osteoclasts and bone marrow stromal cells. in the present review, the latest research investigating the involvement of mirnas, lncrnas and circrnas in regulating the differentiation, proliferation, apoptosis and autophagy of cells that maintain the bone microenvironment in osteoporosis is summarized. deeper insight into the aspects of osteoporosis pathogenesis involving the deregulation of ncrnas could facilitate the development of therapeutic approaches for osteoporosis. Contents 1. introduction 2. Mechanisms by which ncrnas regulate BMScs in osteoporosis 3. Mechanisms by which ncrnas regulate oBs in osteoporosis 4. Mechanisms by which ncrnas regulate ocs in osteoporosis 5. conclusion and perspectives

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miR-205-5p inhibits thymic epithelial cell proliferation via FA2H-TFAP2A feedback regulation in age-associated thymus involution

Cited by 13 publications

References 70 publications

Two types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma

Two types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma

Construction of the miRNA-mRNA Regulatory Networks and Explore Their Role in the Development of Lung Squamous Cell Carcinoma

Effects of miRNAs, lncRNAs and circRNAs on osteoporosis as regulatory factors of bone homeostasis (Review)

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