miR-205-3p Functions as a Tumor Suppressor in Ovarian Carcinoma

Qiao, Baohua; Wang, Qingzhi; Zhao, Yuying; Wu, Jingli

doi:10.1007/s43032-019-00047-y

Cited by 20 publications

(23 citation statements)

References 26 publications

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“…In this study, the survival analysis of Hub gene relating to miR-30a target gene showed that the expression of MAPK10 protein was low and the overall survival time of OC was signi cantly shortened. MAPK10 is inclined to be considered as a tumor suppressor gene in current studies (23), and more studies are needed to verify it. The Tp53 gene encodes a tumor suppressor protein that includes transcriptional activation, DNA binding and oligomerization domains.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis of Prognostic value and prospective Pathway signal of miR-30a in Ovarian Cancer

Wu²,

et al. 2020

Preprint

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Objective: MicroRNAs (MiRNAs) is thought to play an critical role in the initiation and progress of ovarian cancer(OC). Although miRNAs has been widely recognized in ovarian cancer, the role of hsa-miR-30a-5p (miR-30a) in OC has not been fully elucidated.Methods:Three mRNA datasets of normal ovarian tissue and OC, GSE18520 ,GSE14407 and GSE36668, were downloaded from Gene Expression Omnibus(GEO) to find the differentially expressed gene (DEG). Then the target genes of hsa-miR-30a-5p were predicted by miRWALK3.0 and TargetScan. Then, the gene overlap between DEG and the predicted target genes of miR-30a in OC was analyzed by Gene Ontology (GO) enrichment analysis. Protein-protein interaction (PPI) network was conducted by STRING and Cytoscape, and the effect of HUB gene on the outcome of OC was analyzed.Results：A common pattern of up-regulation of miR-30a in OC was found. A total of 225 DEG, were identified, both OC-related and miR-30a-related. Many DEG are enriched in the interactions of intracellular matrix tissue, ion binding and biological process regulation. Among the 10 major Hub genes analyzed by PPI, five Hub genes were significantly related to the overall poor survival of OC patients, in which the low expression of ESR1 ,MAPK10, Tp53 and the high expression of YKT ,NSF were related to poor prognosis of OC.Conclusion：Our results indicate that miR-30a is of significance for the biological progress of OC.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis of Prognostic value and prospective Pathway signal of miR-30a in Ovarian Cancer

Wu²,

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In this study, the survival analysis of Hub gene relating to miR-30a target gene showed that the expression of MAPK10 protein was low and the overall survival time of OC was significantly shortened. MAPK10 is inclined to be considered as a tumor suppressor gene in current studies [22], and more studies are needed to verify it. The Tp53 gene encodes a tumor suppressor protein that includes transcriptional activation, DNA binding and oligomerization domains.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of prognostic value and prospective pathway signal of miR-30a in ovarian cancer

et al. 2020

J Ovarian Res

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Objective MicroRNAs (MiRNAs) is thought to play a critical role in the initiation and progress of ovarian cancer (OC). Although miRNAs has been widely recognized in ovarian cancer, the role of hsa-miR-30a-5p (miR-30a) in OC has not been fully elucidated. Methods Three mRNA datasets of normal ovarian tissue and OC, GSE18520,GSE14407 and GSE36668, were downloaded from Gene Expression Omnibus (GEO) to find the differentially expressed gene (DEG). Then the target genes of hsa-miR-30a-5p were predicted by miRWALK3.0 and TargetScan. Then, the gene overlap between DEG and the predicted target genes of miR-30a in OC was analyzed by Gene Ontology (GO) enrichment analysis. Protein-protein interaction (PPI) network was conducted by STRING and Cytoscape, and the effect of HUB gene on the outcome of OC was analyzed. Results A common pattern of up-regulation of miR-30a in OC was found. A total of 225 DEG, were identified, both OC-related and miR-30a-related. Many DEG are enriched in the interactions of intracellular matrix tissue, ion binding and biological process regulation. Among the 10 major Hub genes analyzed by PPI, five Hub genes were significantly related to the overall poor survival of OC patients, in which the low expression of ESR1,MAPK10, Tp53 and the high expression of YKT,NSF were related to poor prognosis of OC. Conclusion Our results indicate that miR-30a is of significance for the biological progress of OC.

show abstract

“…In this study, the survival analysis of Hub gene relating to miR-30a target gene showed that the expression of MAPK10 protein was low and the overall survival time of OC was significantly shortened. MAPK10 is inclined to be considered as a tumor suppressor gene in current studies (23), and more studies are needed to verify it. The Tp53 gene encodes a tumor suppressor protein that includes transcriptional activation, DNA binding and oligomerization domains.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Values and Prospective Pathway Signaling of miR-30a in Ovarian Cancer: A Study Based on Gene Expression Omnibus and Bioinformatics Analysis

et al. 2020

Preprint

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Objective MicroRNAs (MiRNAs) is considered to play an important role in the occurrence and development of ovarian cancer(OC). Although miRNAs has been widely recognized in ovarian cancer, the role of hsa-miR-30a-5p (miR-30a) in OC has not been fully elucidated. Methods Through the analysis of public data sets in Gene Expression Omnibus (GEO) database and literature review, the significance of miR-30a expression in OC is evaluated. Three mRNA datasets of OC and normal ovarian tissue, GSE14407, GSE18520 and GSE36668, were downloaded from GEO to find the differentially expressed gene (DEG). Then the target genes of hsa-miR-30a-5p were predicted by miRWALK3.0 and TargetScan. Then, the gene overlap between DEG and the predicted target genes of miR-30a in OC was analyzed by Gene Ontology (GO) enrichment analysis. Protein-protein interaction (PPI) network was constructed by STRING and Cytoscape, and the effect of HUB gene on the prognosis of OC was analyzed. Results A common pattern of up-regulation of miR-30a in OC was found. A total of 225 DEG, were identified, both OC-related and miR-30a-related. Many DEG are enriched in the interactions of intracellular matrix tissue, ion binding and biological process regulation. Among the 10 major Hub genes analyzed by PPI, five Hub genes were significantly related to the overall poor survival of OC patients, in which the low expression of ESR1 ,MAPK10, Tp53 and the high expression of YKT ,NSF were related to poor prognosis of OC.

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miR-205-3p Functions as a Tumor Suppressor in Ovarian Carcinoma

Cited by 20 publications

References 26 publications

Bioinformatics Analysis of Prognostic value and prospective Pathway signal of miR-30a in Ovarian Cancer

Bioinformatics Analysis of Prognostic value and prospective Pathway signal of miR-30a in Ovarian Cancer

Bioinformatics analysis of prognostic value and prospective pathway signal of miR-30a in ovarian cancer

Prognostic Values and Prospective Pathway Signaling of miR-30a in Ovarian Cancer: A Study Based on Gene Expression Omnibus and Bioinformatics Analysis

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