miR-204 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) replication via inhibiting LC3B-mediated autophagy

Yao, Yao; Li, Sihan; Zhu, Yingqi; Xu, Yangyang; Hao, Siyuan; Guo, Shuangshuang; Feng, W.-h.

doi:10.1016/j.virs.2023.07.004

Cited by 4 publications

(1 citation statement)

References 46 publications

(48 reference statements)

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“…A recent study revealed that miR-204 was expressed at low levels in PRRSV target cells, specifically PAMs, while it was highly expressed in non-permissive cells, which include porcine peritoneal macrophages (PPMs). Overexpression of miR-204 effectively inhibited PRRSV infection [ 147 ]. Further research discovered that miR-204 specifically targeted microtubule-associated protein 1 light chain 3B (MAP1LC3B, LC3B), leading to the inhibition of both PRRSV infection and autophagy.…”

Section: Ncrna During Porcine Virus Infectionmentioning

confidence: 99%

Regulatory Non-Coding RNAs during Porcine Viral Infections: Potential Targets for Antiviral Therapy

Li,

Yu,

et al. 2024

Viruses

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Pigs play important roles in agriculture and bio-medicine; however, porcine viral infections have caused huge losses to the pig industry and severely affected the animal welfare and social public safety. During viral infections, many non-coding RNAs are induced or repressed by viruses and regulate viral infection. Many viruses have, therefore, developed a number of mechanisms that use ncRNAs to evade the host immune system. Understanding how ncRNAs regulate host immunity during porcine viral infections is critical for the development of antiviral therapies. In this review, we provide a summary of the classification, production and function of ncRNAs involved in regulating porcine viral infections. Additionally, we outline pathways and modes of action by which ncRNAs regulate viral infections and highlight the therapeutic potential of artificial microRNA. Our hope is that this information will aid in the development of antiviral therapies based on ncRNAs for the pig industry.

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Section: Ncrna During Porcine Virus Infectionmentioning

confidence: 99%