miR-202 suppresses proliferation and induces apoptosis of osteosarcoma cells by downregulating Gli2

Sun, Zhengwen; Zhang, Tongqing; Hong, Huanyu; Qingxia, Liu; Zhang, Haiguang

doi:10.1007/s11010-014-2195-z

Cited by 43 publications

(36 citation statements)

References 28 publications

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“…Increasing reports have demonstrated that the alteration of miRNAs is related to the development of different tumors, such as pancreatic cancer, lung cancer, and breast cancer [16–18]. Accumulating studies showed that the expression of miR-202 was deregulated in different cancers, including colorectal carcinoma [19], gastric cancer [20], myeloma [21], osteosarcoma and lung carcinoma [22, 23]. Recently miR-202 was reported as a tumor suppressor miRNA.…”

Section: Introductionmentioning

confidence: 99%

miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1

et al. 2016

Oncotarget

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Section: Introductionmentioning

confidence: 99%

miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1

et al. 2016

Oncotarget

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“…The expression levels of miR-202 are associated with the proliferation, invasion, metastasis, apoptosis and angiogenesis of numerous tumor tissue types, including gastric, liver and pancreatic cancer (16)(17)(18)(19). Analysis of the expression levels of genes in ESCC tissue, using the database of Gene Expression Omnibus (GSE20347), indicated that 1,755 genes were differentially expressed in ESCC tissues, including miR-202 (20).…”

Section: Introductionmentioning

confidence: 99%

Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma

Zhang

Dong

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to determine the expression levels and biological functions of in patients with esophageal squamous cell carcinoma (ESCC). A total of 60 patients with ESCC and 30 healthy individuals were enrolled and reverse transcription-quantitative polymerase chain reaction was performed to measure the expression levels of miR-202. In order to investigate the effects of miR-202 expression levels on the proliferative, migratory and invasive abilities of ESCC cells, methylthiazolyl-tetrazolium bromide proliferation, in vitro scratch and Transwell ® chamber assays were performed. Expression levels of miR-202 were significantly decreased in the peripheral blood of patients with ESCC, which is associated with the degree of cell differentiation and lymph node metastasis (P<0.05). Following miR-202 transfection, cell proliferation was significantly inhibited (P<0.05). Cell migration and invasion was also significantly inhibited by miR-202 transfection (P<0.05). The results of the present study demonstrated that the expression of miR-202 inhibited the proliferation, migration and invasion of ESCC cells. Furthermore, low expression levels of miR-202 were detected in the peripheral blood of patients with ESCC, which is associated with the development, invasion and metastasis of ESCC.

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“…Thirty six of the publications met the criteria were included in the final meta-analysis. Thirty three of the publications were reported in English [17, 25, 32-62], and 3 of them were reported in Chinese [63-65]. …”

Section: Resultsmentioning

confidence: 99%

MicroRNAs for osteosarcoma in the mouse: a meta-analysis

Chang

Yao

et al. 2016

Oncotarget

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Osteosarcoma (OS) is the most common primary malignant bone carcinoma with high morbidity that happens mainly in children and young adults. As the key components of gene-regulatory networks, microRNAs (miRNAs) control many critical pathophysiological processes, including initiation and progression of cancers. The objective of this study is to summarize and evaluate the potential of miRNAs as targets for prevention and treatment of OS in mouse models, and to explore the methodological quality of current studies. We searched PubMed, Web of Science, Embase, Wan Fang Database, VIP Database, China Knowledge Resource Integrated Database, and Chinese BioMedical since their beginning date to 10 May 2016. Two reviewers separately screened the controlled studies, which estimate the effects of miRNAs on osteosarcoma in mice. A pair-wise analysis was performed. Thirty six studies with enough randomization were selected and included in the meta-analysis. We found that blocking oncogenic or restoring decreased miRNAs in cancer cells could significantly suppress the progression of OS in vivo, as assessed by tumor volume and tumor weight. This meta-analysis suggests that miRNAs are potential therapeutic targets for OS and correction of the altered expression of miRNAs significantly suppresses the progression of OS in mouse models, however, the overall methodological quality of studies included here was low, and more animal studies with the rigourous design must be carried out before a miRNA-based treatment could be translated from animal studies to clinical trials.

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miR-202 suppresses proliferation and induces apoptosis of osteosarcoma cells by downregulating Gli2

Cited by 43 publications

References 28 publications

miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1

miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1

Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma

MicroRNAs for osteosarcoma in the mouse: a meta-analysis

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