miR-200b Inhibits Prostate Cancer EMT, Growth and Metastasis

Williams, LaTanya V; Veliceasa, Dorina; Vinokour, Elena; Volpert, Olga V.

doi:10.1371/journal.pone.0083991

Cited by 113 publications

(95 citation statements)

References 45 publications

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“…miR-200b, Zeb1 siRNA, and Diabetes Induce Beta Cell E-cadherin-Members of the miR-200 family have also been implicated in EMT (31,33,34), and increased Zeb1 expression (as observed in response to miR-200b knockdown (Fig. 5F)) and decreased E-cadherin expression are strong markers for EMT (10,35,36).…”

Section: Mir-200b Targets and Decreases Beta Cell Zeb1-we Next Wantedmentioning

confidence: 96%

MicroRNA-200 Is Induced by Thioredoxin-interacting Protein and Regulates Zeb1 Protein Signaling and Beta Cell Apoptosis

Filios

Chen

et al. 2014

Journal of Biological Chemistry

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Background: Beta cell apoptosis is a key factor in diabetes, but the mechanisms are not well understood. Results: Beta cell miR-200 is induced by thioredoxin-interacting protein (TXNIP) and diabetes, directly targets Zeb1, up-regulates E-cadherin, and promotes apoptosis. Conclusion: This novel TXNIP/miR-200/Zeb1/E-cadherin signaling pathway links miR-200 to beta cell apoptosis, control of epithelial-mesenchymal transition, and diabetes. Significance: The results provide new insight into microRNA biology and the regulation of beta cell apoptosis.

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Section: Mir-200b Targets and Decreases Beta Cell Zeb1-we Next Wantedmentioning

confidence: 96%

MicroRNA-200 Is Induced by Thioredoxin-interacting Protein and Regulates Zeb1 Protein Signaling and Beta Cell Apoptosis

Filios

Chen

et al. 2014

Journal of Biological Chemistry

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“…Moreover, serum level of miR-16 has been reported to be up-regulated in patients with stages 3 and 4 PCa compared to normal donors, suggesting its potential to be used as a diagnostic marker of PCa [95]. and metastasis potential of PC-3 cells [102]. Similar results were also confirmed in another EMT model of DU145-LN4 that decreased expression of miR-200 family induced and EMT phenotype [103].…”

Section: Tumor Suppressor Mirnas In Pcamentioning

confidence: 57%

MicroRNAs in Prostate Cancer: Small RNAs with Big Roles

Deng²,

Fan³

2015

J Clin Cell Immunol

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MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression either by mediating translational repression or reducing the stability of a target mRNA. Deregulated expression of miRNAs is a common feature of human cancers and a growing body of evidence demonstrates the role of miRNAs as either oncogenes or tumor suppressors. Many miRNAs have been reported to be associated with the pathogenesis of primary prostate cancer (PCa) and the development of castration resistant prostate cancer (CRPC). PCa is the most common cancer and second leading cause of cancer death in American men. Although patients with primary PCa can be treated with chemotherapy and hormone therapy, many of them will develop resistance to conventional therapies and progress to a more sever condition called CRPC, which remains one of the most difficult cancers to treat. Since emerging evidence suggests miRNAs' significant roles in the tumorigenesis of primary PCa and CRPC, the potential of using miRNAs as drug targets and biomarkers for primary PCa and CRPC has been gaining more attention. The aim of this review is to summarize recent studies on the involvements and mechanisms of the actions of several miRNAs in the development and progression of primary PCa and CRPC. Additionally, the potentail applications of using miRNAs as biomarkers and drug targets are briefly discussed.

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“…Similarly, miR-135a and miR-200b, which attenuate prostate cancer cell migration, invasion and growth, are upregulated by AR (80,81).…”

Section: Discussionmentioning

confidence: 99%

miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer

Pasqualini

Puhr

et al. 2015

Molecular Endocrinology

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The normal prostate as well as early stages and advanced prostate cancer (PCa) require a functional androgen receptor (AR) for growth and survival. The recent discovery of microRNAs (miRNAs) as novel effector molecules of AR disclosed the existence of an intricate network between AR, miRNAs and downstream target genes. In this study DUCaP cells, characterized by high content of wild-type AR and robust AR transcriptional activity, were chosen as the main experimental model. By integrative analysis of chromatin immunoprecipitation-sequencing (ChIP-seq) and microarray expression profiling data, miRNAs putatively bound and significantly regulated by AR were identified. A direct AR regulation of miR-22, miR-29a, and miR-17-92 cluster along with their host genes was confirmed. Interestingly, endogenous levels of miR-22 and miR-29a were found to be reduced in PCa cells expressing AR. In primary tumor samples, miR-22 and miR-29a were less abundant in the cancerous tissue compared with the benign counterpart. This specific expression pattern was associated with a differential DNA methylation of the genomic AR binding sites. The identification of laminin gamma 1 (LAMC1) and myeloid cell leukemia 1 (MCL1) as direct targets of miR-22 and miR-29a, respectively, suggested a tumor-suppressive role of these miRNAs. Indeed, transfection of miRNA mimics in PCa cells induced apoptosis and diminished cell migration and viability. Collectively, these data provide additional information regarding the complex regulatory machinery that guides miRNAs activity in PCa, highlighting an important contribution of miRNAs in the AR signaling.

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miR-200b Inhibits Prostate Cancer EMT, Growth and Metastasis

Cited by 113 publications

References 45 publications

MicroRNA-200 Is Induced by Thioredoxin-interacting Protein and Regulates Zeb1 Protein Signaling and Beta Cell Apoptosis

MicroRNA-200 Is Induced by Thioredoxin-interacting Protein and Regulates Zeb1 Protein Signaling and Beta Cell Apoptosis

MicroRNAs in Prostate Cancer: Small RNAs with Big Roles

miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer

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