miR-19a Promotes Cell Growth and Tumorigenesis through Targeting SOCS1 in Gastric Cancer

Qin, Shuang; Ai, Fang; Ji, Wei-Fang; Wang, Rao; Zhang, He-Cheng; Yao, Wenjian

doi:10.7314/apjcp.2013.14.2.835

Cited by 45 publications

(40 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gregory reported that miRNAs, such as smiR-200 family and miR-205, act as key modulators of EMT and enforcers of the epithelial phenotype targeting ZEB1 and SIP1 [26]. Dong et al demonstrated miR-194 directly targets BMI-1, and reverses EMT phenotype in endometrial cancer cells [27]. To the best of our knowledge, however, the definitive association of miR-19a with EMT of GC has not been reported, only given the evidences showing that the oncogenic effect of miR-19a was mediated by repression of SOCS1, MXD1 [6,27].…”

Section: Discussionmentioning

confidence: 99%

“…Dong et al demonstrated miR-194 directly targets BMI-1, and reverses EMT phenotype in endometrial cancer cells [27]. To the best of our knowledge, however, the definitive association of miR-19a with EMT of GC has not been reported, only given the evidences showing that the oncogenic effect of miR-19a was mediated by repression of SOCS1, MXD1 [6,27]. For the first time, we found that up-regulation of miR-19a level is able to induce EMT in GC cells, evidenced by epithelial like morphology, increased expression of E-cadherin and decreased expression of vimentin.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer

Lü

Zuo

et al. 2015

WJG

View full text Add to dashboard Cite

It has been reported that miR-19a was up-regulated in gastric cancer (GC), playing an oncogenic role. However, the underlying mechanism is still unknown. Therefore, in our present study, we investigated the role of miR-19a in gastric tissues as well as 2 GC cell lines. In vivo in clinical tissue level, we have detected basal expression level of miR-19a using real-time reversal transcriptional PCR (RT-PCR); in addition, the relevance between expression of miR-19a and clinic-pathological information was also analyzed. In vitro in cell line level, miR-19a was ectopically expressed using over expression and knock-down strategy. It was found that the overexpression of miR19a was significantly associated with metastasis of GC and inferior overall prognosis on clinical tissue level; that promotes the proliferation, migration and invasion; and that overexpression of miR-19a can promote the epithelialmesenchymal transition through activating PI3K/AKT pathway. Blocking the PI3K/AKT pathway could cancel the effect of miR-19a. All together, our results suggest that miR-19a could be used as a promising therapeutic target in the treatment of GC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer

Lü

Zuo

et al. 2015

WJG

View full text Add to dashboard Cite

show abstract

“…Accumulating evidence has shown that miRNAs have crucial functions in specific cellular processes such as differentiation, morphogenesis, and tumorigenesis. In human cancer, miRNAs can function as oncogenes (Qin et al, 2013) or tumor suppressor genes (Hagman et al, 2013) during tumorigenesis. Gene expression profiling studies have demonstrated that miRNA expression is an excellent biomarker associated with specific tumor subtypes and clinical outcomes (Dieckmann et al, 2012;Takahashi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

miRNA-218 Inhibits Osteosarcoma Cell Migration and Invasion by Down-regulating of TIAM1, MMP2 and MMP9

Jin

Cai²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

103

View full text Add to dashboard Cite

Deregulated miRNAs participate in osteosarcoma genesis. In this study, the expression of miRNA-218 in human osteosarcomas, adjacent normal tissues and Saos-2 human osteosarcoma cells was first assessed. Then the precise role of miRNA-218 in osteosarcoma cells was investigated. Upon transfection with a miR-218 expression vector, the proliferation of Saos-2 human osteosarcoma cells determined using the ATPlite assay was significantly suppressed, whilw migration of Saos-2 cells detected by wound healing and invasion determined using transwells were dramatically inhibited. Potential target genes of miR-218 were predicted and T-cell lymphoma invasion and metastasis 1 (TIAM1) and matrix metalloproteinase 2 (MMP2) and 9 (MMP9) were identified. This was confirmed by western blotting, which showed that miR-218 expression inhibited TIAM1, MMP2 and MMP9 protein expression. Collectively, these data suggest that miR-218 acts as a tumor suppressor in osteosarcomas by down-regulating TIAM1, MMP2 and MMP9 expression.

show abstract

“…miR-19a functions as an oncogenic miRNA in gastric cancer by repressing the expression of tumor suppressor gene SOCS1 (Suppressor of cytokine signaling 1) [17]. miR-296-5p increased cell proliferation in gastric cancer through repression of caudal-related homeobox 1 [18].…”

Section: The Involvement Of Mirnas As Oncogenes or Tumor Suppressors mentioning

confidence: 99%

The Role of miRNAs in Gastric Cancer

Tang¹,

Tang²,

Xie³

2013

J Gastrointest Dig Syst

View full text Add to dashboard Cite

Despite promising developments of treatment, the mortality of gastric cancer remains high. MicroRNAs (miRNAs) are non-coding RNA molecules. There are extensive evidences that miRNAs play a dual role, as oncogenes or tumor suppressors through regulating cell proliferation, differentiation, and apoptosis. Additionally, some miRNAs, as promising diagnostic and prognostic biomarkers, are specifically related to gastric cancer. In the current review, we have summarized recent data concerning miRNAs in patient with gastric cancer, allowing us a better understanding miRNA as the prognostic and diagnostic biomarkers and the new targets for clinical therapeutic interventions for gastric cancer.

show abstract

miR-19a Promotes Cell Growth and Tumorigenesis through Targeting SOCS1 in Gastric Cancer

Cited by 45 publications

References 25 publications

MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer

MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer

miRNA-218 Inhibits Osteosarcoma Cell Migration and Invasion by Down-regulating of TIAM1, MMP2 and MMP9

The Role of miRNAs in Gastric Cancer

Contact Info

Product

Resources

About