MiR-19a as a prognostic indicator for cancer patients: a meta-analysis

Abstract

MiR-19a was aberrantly expressed in various types of cancers and was observed to be potentially associated with the prognosis of cancer patients. The present analysis aims to elucidate its precise predictive value in various human malignancies. Online electronic searches of PubMed, Web of Science (WOS), Embase in English and VIP, Wanfang, SinoMed, and the China National Knowledge Infrastructure (CNKI) in Chinese up to September 8, 2018 were conducted. As a result, in overall analysis, a significant association was identified between miR-19a levels and OS (HRs = 2.31, CI: 1.11–4.83). The relation of miR-19a expression to OS was further recognized by fixed model within the studies of sample size less than 150 (HRs = 1.68, CI: 1.35–2.08), NOS scores greater than or equal to 8 (HRs = 1.53, CI: 1.13–2.06) or less than 8 (HRs = 1.89, CI: 1.58–2.27), specimen derived from tumor (HRs = 1.73, CI: 1.42–2.12) or blood (HRs = 1.87, CI: 1.46–2.40) and the patients of osteosarcoma (HRs = 7.17, CI: 5.04–10.21). Sensitivity analyses revealed no significant results. The association between miR-19a expression level and DFS was also found to be significant (HRs = 2.03, CI: 1.13–3.66). Correlations between miR-19a levels and clinicopathological features were examined and revealed that lymph node metastasis was significantly associated with miR-19a expression levels (OR = 0.565, CI: 0.346–0.921). Summarily, the over expression of miR-19a was an underlying risk of poor prognosis in many human malignancies, especially in osteosarcoma. Moreover, elevated miR-19a expression was linked to the potential of lymph node metastasis.

Bioinformatics Characterization of Candidate Genes Associated with Gene Network and miRNA Regulation in Esophageal Squamous Cell Carcinoma Patients

“…Jiang et al identified that the miR-19b-3p significantly upregulated and led to colon cancer progression in 211 colon samples [79]. Similarly, overexpression of miR-19a was linked to a poor prognosis in various human cancers, including ESCC [80]. Our results revealed that the predicted HmiRT10 could be used as independent predictive biomarkers for the appropriate identification and treatment of ESCC.…”

<em>miR-19a</em> targeting <em>CLCA4</em> to regulate the proliferation, migration, and invasion of colorectal cancer cells

“…37 Overexpression of miR-19a is a risk factor for poor prog- Article nosis in osteosarcoma, and is linked to the metastatic potential of the lymph nodes. 38 Moreover, overexpression of miR-19a contributes to chemoresistance in ovarian cancer and non-small cell lung cancers. 39,40 However, the role of miR-19a in CRC is controversial.…”

Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis

“…In a previous study by Hu et al, miR-19a-3p was identified as one of the most significantly upregulated miRNAs in hepatocellular carcinoma cells cultured under hypoxic conditions [ 21 ]. Upregulation of miR-19a has been analyzed as an independent risk of poor prognosis in multiple human malignancies [ 22 ]. In agreement with this, miR-19a has been found to be upregulated and play oncogenic roles in several cancers [ 23 , 24 ], including CRC [ 25 , 26 ].…”