MiR-196a2 rs11614913 T&gt;C polymorphism and risk of esophageal cancer in a Chinese population

Wei, Jishu; Zheng, Liang; Liu, Shenghua; Yin, Jun; Wang, Liming; Wang, Xu; Shi, Yijun; Shao, Aizhong; Tang, Weifeng; Ding, Guowen; Liu, Chao; Chen, Suocheng; Gu, Heng

doi:10.1016/j.humimm.2013.06.012

Cited by 58 publications

(51 citation statements)

References 27 publications

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“…There were fifteen studies of caucasian descent and twenty-four studies of Asian descent. The genotype distributions in the controls of fourteen studies were not conforming to HWE (p<0.05) (Okubo et al, 2010;Akkiz et al, 2011;Ling et al, 2011;Mittal et al, 2011;Zhou et al, 2011;Xiang et al, 2012;Shan et al, 2013;Vinci et al, 2013;Wei et al, 2013;Zou and Zhao, 2013;Bansal et al, 2014;Ma et al, 2014;Omrani et al, 2014;Wang et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

“…One study was excluded as it was not associated with hsa-mir-499 rs3746444 A>G (Kupcinskas et al, 2012). After further excluding two abstracts (Hu et al, 2009;Hwang et al, 2010), thirty-nine case-control studies involving 14,136 cases and 16,937 controls were selected for meta-analysis (Hu et al, 2009;Tian et al, 2009;Catucci et al, 2010;Liu et al, 2010;Okubo et al, 2010;Srivastava et al, 2010;Akkiz et al, 2011;George et al, 2011;Ling et al, 2011;Mittal et al, 2011;Vinci et al, 2011;Zhou et al, 2011;Alshatwi et al, 2012;Chu et al, 2012;Kim et al, 2012;Min et al, 2012;Xiang et al, 2012;Zhou et al, 2012;Ahn et al, 2013;Lv et al, 2013;Shan et al, 2013;Song et al, 2013;Umar et al, 2013;Vinci et al, 2013;Wei et al, 2013;Wu et al, 2013;Zou and Zhao, 2013;Bansal et al, 2014;Chu et al, 2014;Du et al, 2014;Gutierrez-Camino et al, 2014;Hasani et al, 2014;Hou et al, 2014;Hu et al, 2014;Ma et al, 2014;Omrani et al, 2014;Pu et ...…”

Section: Methodsmentioning

confidence: 99%

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Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Jiang

Chen²,

Tang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Epidemiologic findings concerning the association between the hsa-mir-499 rs3746444 A>G polymorphism and cancer risk have yielded mixed results. We aimed to investigate the association by performing a meta-analysis of all available studies. We searched PubMed and EMBASE for studies published up to November 2014, using odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of any association. The BenjaminiHochberg (BH) method was used to correct the p values for multiple comparisons. We included 39 studies, including 14,136 cases and 16,937 controls. The results of overall meta-analysis suggested a borderline association between hsa-mir-499 rs3746444 polymorphism and cancer susceptibility (AG+GG vs. AA: OR=1.15, 95% CI= 1.04-1.26, corrected p value=0.04). After removing studies not conforming to Hardy-Weinberg equilibrium (HWE), however, this association disappeared (AG+GG vs AA: OR=1.18, 95% CI=1.03-1.34, corrected p value=0.21). When stratified analysis by ethnicity, cancer type or HWE in controls, although some associations between hsa-mir-499 rs3746444 polymorphism and cancer susceptibility were detected, these associations no longer existed after adjustment using BH method. In conclusion, our meta-analysis suggests that hsa-mir-499 rs3746444 A>G polymorphism is not associated with risk of cancer based on current evidence. conclusive. Many meta-analyses have examined the association of the polymorphism with cancer risk and the lasted one suggested that hsa-mir-499 rs3746444 polymorphism was a risk factor for cancer development. Since the latest meta-analysis had been performed, nineteen case-control studies (Ling

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Jiang

Chen²,

Tang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Twenty-five abstracts were retrieved through the search "miR-27a", "polymorphism" and "cancer", and eleven articles were identified as eligible studies (Sun et al, 2010;Yang et al, 2010;Catucci et al, 2012;Hezova et al, 2012;Shi et al, 2012;Zhang et al, 2012;Zhou et al, 2012;Wei et al, 2013;Zhang et al, 2013;Xiong et al, 2014;Yang et al, 2014). Out of the Twenty-five, seven articles were pooled analysis, commentary and review papers (Wang et al, 2012;Yang and Burwinkel, 2012;Ma et al, 2013;Wang et al, 2013;Xu et al, 2013b;Zhong et al, 2013;Chen et al, 2014), and four reports were cancer biology experimental studies (Hirota et al, 2012;Jahid et al, 2012;Zanetti et al, 2012;Yuan et al, 2013).…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…Due to limited studies and data presented in original reports, however, these meta-analysis studies did not calculate the pooled odd ratio (OR) for different subgroups of breast cancers or other types of cancers. Furthermore, recent studies showed controversial results on the association of rs895819 with cancer risk (Wei et al, 2013;Zhang et al, 2013;Kupcinskas et al, 2014;Xiong et al, 2014;Yang et al, 2014). To clarify the association between rs895819 and cancer risk, in this study, we performed additional pooling analyses by including more recent publications to improve the efficiency of meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

Bai

Weng²,

Su³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Sample DNA (10 ng) was amplified by polymerase chain reaction (PCR) according to the manufacturer's recommendations. As previously described, a custom-by-design 48-Plex SNPscan™ kit (Genesky Biotechnologies, Inc., Shanghai, China) was used to determine the genotypes of the four SNPs (32)(33)(34)(35). This kit was developed according to patented SNP genotyping technology by Genesky Biotechnologies, which was mainly based on double ligation and multiplex fluorescence PCR.…”

Section: Methodsmentioning

confidence: 99%

IL18 rs360719 A>G, IL18R1 rs13015714 G>T, IL18RAP rs917997 C>T and IL28B rs8099917 T>G polymorphisms and risk of gastric cardiac adenocarcinoma

et al. 2017

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Abstract. The present study was conducted to investigate the association between gastric cardiac adenocarcinoma (GCA) and four functional single-nucleotide polymorphisms (SNPs), including interleukin 18 (IL18) rs360719 A>G, IL18 receptor 1 (IL18R1) rs13015714 G>T, IL18 receptor accessory protein (IL18RAP) rs917997 C>T and interleukin 28B (IL28B) rs8099917 T>G variants. A hospital-based case-control study was performed to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscan™ kit was used to determine the genotypes. When the IL18 rs360719 AA homozygote genotype was used as the reference group, the AG genotype was not associated with the risk for GCA; the GG genotype was also not associated with the risk for GCA. In the dominant model, the IL18 rs360719 AG/GG variants were not associated with the risk for GCA, compared with the IL18 rs360719 AA genotype. In the recessive model, when the IL18R1 rs13015714 AA/AG genotypes were used as the reference group, the GG homozygote genotype was not associated with risk for GCA. No association was observed between IL18R1 rs13015714 G>T, IL18RAP rs917997 C>T and IL28B rs8099917 T>G polymorphisms and the risk for GCA. These results demonstrated that the functional polymorphisms IL18 rs360719 A>G, IL18R1 rs13015714 G>T, IL18RAP rs917997 C>T and IL28B rs8099917 T>G do not contribute to GCA susceptibility. However, as the statistical power of our study was limited, large well-designed studies and further functional investigations are required to confirm our findings.

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MiR-196a2 rs11614913 T>C polymorphism and risk of esophageal cancer in a Chinese population

Cited by 58 publications

References 27 publications

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

IL18 rs360719 A>G, IL18R1 rs13015714 G>T, IL18RAP rs917997 C>T and IL28B rs8099917 T>G polymorphisms and risk of gastric cardiac adenocarcinoma

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