miR-196a Overexpression and miR-196a2 Gene Polymorphism Are Prognostic Predictors of Oral Carcinomas

Abstract

High miR-196a expression in tumor tissue and the presence of the TT variant of miR-196a2 gene indicate worse survival in OSCC.

MicroRNA-196a2 Biomarker and Targetome Network Analysis in Solid Tumors

“…[20] in their meta-analysis observed that the significant risk of CT/TT genotypes was more evident in breast cancer and lung cancer in the former study and in breast cancer, Chinese, and Indian populations in the later one. This SNP, in addition, was shown to impact the risk of digestive system cancers [90], esophageal cancer [91], gastric cancer [14,92,93], the overall survival of patients with advanced gastric cancer [94], HCC and liver cirrhosis [70,95,96], gallbladder cancer [97], breast cancer [88,98,99], lung cancer [15,43,[100][101][102][103], prostate cancer [104], and others [105,106], although not in all studied populations [107][108][109][110]. These differences might reflect the fact that different ethnic and environmental exposures may have modified the risk of cancer.…”

Association Between Single Nucleotide Polymorphisms in miRNA196a-2 and miRNA146a and Susceptibility to Hepatocellular Carcinoma in a Chinese Population

“…The C>T substitution polymorphism in miRNA196a-2 (rs11614913) is one of the most frequently studied miRNA SNPs and has been reported to be associated with several types of cancer, such as non-small-cell lung cancer (Hu et al, 2008), breast cancer (Hoffman et al, 2009), gastric cancer (Peng et al, 2010) and oral carcinomas (Liu et al, 2012). Previous studies have also investigated its relationship to the susceptibility to HCC but conflicting results were displayed, even between meta-analyses (Wang et al, 2012;.…”

“…It was well documented that miRNA196a-2 was over-expressed in a wide variety of malignancies (Liu et al, 2012). The substitution from C to T of rs11614913 could alter miRNA processing and lead to the reduction of mature miRNA196a-2 (Ryan et al, 2010).…”

Plasma miR-187* is a potential biomarker for oral carcinoma

“…In support of this notion, we noted shorter survival in patients in whom miR-187* did not decrease following tumor resection. Thus, plasma miR-187* is a potential predictor for OSCC recurrence during follow-up [37], and circulating miR-187* levels might be useful as a non-invasive marker for OSCC diagnosis and prognosis. Recent evidence suggests that the function, regulation, and involvement of miRNA*s in pathogenesis have been underestimated [28,30,32,33].…”