miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma

Lian, Jiamei; Jing, Ying; Dong, Qiongzhu; Huan, Lin; Chen, Di; Bao, Chunyang; Wang, Qifeng; Zhao, Fangyu; Li, Jinjun; Yao, Ming; Qin, Lun–Xiu; Liang, Linhui; He, Xianghuo

doi:10.18632/oncotarget.6603

Cited by 72 publications

(68 citation statements)

References 38 publications

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“…Unique patterns of miRNA expression have been established as a potential marker for sub-classification, diagnosis, prognosis, and therapeutic targets in HCC. Reports show that various miRNAs involve in HCC oxidative stress, cell proliferation, cell-cycle, and progression [6][7][8][9][10]. In this study, we elucidated the post-transcriptional inhibition of ZEB2 under the regulation of miR-211-5p in HCC cells.…”

Section: Discussionmentioning

confidence: 76%

“…Reports show that miR-17-92 cluster, miR-1180, miR-107, and miR-25 are consistently up-regulated in primary HCC tissues [6][7][8][9]. MiR-192, miR-122, miR-34a, and miR-149 are commonly down-regulated in HCC [10][11][12][13]. Some miRNAs targeting signaling pathways including Wnt/b-catenin, Ras, TGF-b, and JAK/STAT regulate HCC progression [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Regulatory role of miR-211-5p in hepatocellular carcinoma metastasis by targeting ZEB2

Jiang

Wen

Deng

et al. 2017

Biomedicine & Pharmacotherapy

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Regulatory role of miR-211-5p in hepatocellular carcinoma metastasis by targeting ZEB2

Jiang

Wen

Deng

et al. 2017

Biomedicine & Pharmacotherapy

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“…In our previous analysis, we observed that miR-192 was overexpressed in PCa. Several studies have demonstrated that miR-192 is involved in the progression of human cancer, including bladder cancer [14], acute lymphoblastic leukemia [15], and hepatocellular carcinoma [16]. However, the roles of miR-192 in tumor progression remain uncertain, and miR-192 could act as an oncogene.…”

Section: Introductionmentioning

confidence: 99%

miR-192 Is Overexpressed and Promotes Cell Proliferation in Prostate Cancer

et al. 2018

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Objective: Prostate cancer (PCa) is one of the most prevalent types of cancer among men worldwide. The incidence of PCa is increasing in China. Therefore, there is an urgent need to identify novel diagnostic and prognostic markers for PCa to improve the treatment of the disease. Methods: The Cancer Genome Atlas (TCGA) and GEO database were used to analyze the expression of miR-192, and the relationship between miR-192 and the clinical features of patients with PCa. Cell cycle and cell proliferation assay were used to detect the functional roles of miR-192 in PCa. Bioinformatic analysis for miR-192–5p was performed using gene ontology and KEGG analysis. Results: By analyzing the dataset of TCGA, we found that miR-192 was overexpressed in PCa samples compared to normal tissues and was upregulated in high-grade PCa compared to low-grade PCa. We also observed that higher miR-192 expression was associated with a shorter biochemical recurrence-free survival time. Our results also demonstrated that miR-192 promoted PCa cell proliferation and cell cycle progression. Conclusion: These results suggest that miR-192 may be considered for use as a potential diagnostic and therapeutic target of PCa.

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“…Loss of p53 functions by mutation and consequently decreased expression of miR-192 has been suggested to be a key step in colon carcinogenesis (3,11,25,29). Although miR-192 is not considered to be a typically dysregulated microRNA in several studies on hepatocellular carcinoma (HCC), Lian et al (19) showed a significantly suppressed expression of miR-192 in HCC tissue compared with nontumorous tissue. An important role of miR-192 targeting ZEB2 mRNA has also been found in HCC (13).…”

mentioning

confidence: 99%

microRNA-192 suppresses the expression of the farnesoid X receptor

Krattinger

Boström

Schiöth

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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Farnesoid X receptor (FXR, NR1H4) plays an important role in the regulation of bile acid homeostasis in liver and intestine and may exert protective effects against certain forms of cancer such as colon carcinoma. However, the role of FXR in cell growth regulation, apoptosis, and carcinogenesis is still controversial. Similar to FXR, microRNA-192 (miR-192) is mainly expressed in the liver and colon and plays an important role in the pathogenesis of colon carcinoma. In this study, we investigated the extent to which FXR is regulated by miR-192. Two in silico-predicted binding sites for miR-192-3p within the NR1H4-3' untranslated region (UTR) were examined in vitro by luciferase reporter assays. Wild-type and mutated forms of the NR1H4-3'UTR were subcloned into a pmirGLO vector and cotransfected into Huh-7 cells with miR-192-3p. To study the effects of miR-192 on the expression of FXR, FXR target genes and cell proliferation, Huh-7 and Caco-2 cells were transfected with miR-192-5p and -3p mimics or antagomirs. In addition, the correlation between FXR and miR-192 expression was studied by linear regression analyses in colonic adenocarcinoma tissue from 27 patients. MiR-192-3p bound specifically to the NR1H4-3'UTR and significantly decreased luciferase activity. Transfection with miR-192 led to significant decreases in NR1H4 mRNA and protein levels as well as the mRNA levels of the FXR-inducible bile acid transporters OSTα-OSTβ and OATP1B3. Significant inverse correlations were detected in colonic adenocarcinoma between NR1H4 mRNA and miR-192-3p expression. In summary, microRNA-192 suppresses the expression of FXR and FXR target genes in vitro and in vivo.

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miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma

Cited by 72 publications

References 38 publications

Regulatory role of miR-211-5p in hepatocellular carcinoma metastasis by targeting ZEB2

Regulatory role of miR-211-5p in hepatocellular carcinoma metastasis by targeting ZEB2

miR-192 Is Overexpressed and Promotes Cell Proliferation in Prostate Cancer

microRNA-192 suppresses the expression of the farnesoid X receptor

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