2019
DOI: 10.1186/s13046-019-1039-9
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miR-190 enhances endocrine therapy sensitivity by regulating SOX9 expression in breast cancer

Abstract: BackgroundBreast cancer is the most common cancer among women worldwide, and approximately 70% of breast cancers are hormone receptor-positive and express estrogen receptor-α (ERα) or/and progesterone receptor. Therapies targeting ERα have been successfully used in patients with ERα+ breast cancer. However, intrinsic or acquired resistance to anti-estrogen therapy presents a major challenge. The Wnt/β-catenin signaling pathway regulates various processes that are important for cancer progression, and emerging … Show more

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Cited by 47 publications
(28 citation statements)
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“…MicroRNAs (miRNAs), which are a kind of conserved non-coding RNAs, regulate the expression of proteins via binding with the 3ʹ-untranslated region (3ʹ-UTR) of target mRNA 4,5. The functions of miRNAs in many biological processes, including cancer cell growth, apoptosis, migration and metastasis, have been widely investigated 6.…”
Section: Introductionmentioning
confidence: 99%
“…MicroRNAs (miRNAs), which are a kind of conserved non-coding RNAs, regulate the expression of proteins via binding with the 3ʹ-untranslated region (3ʹ-UTR) of target mRNA 4,5. The functions of miRNAs in many biological processes, including cancer cell growth, apoptosis, migration and metastasis, have been widely investigated 6.…”
Section: Introductionmentioning
confidence: 99%
“…MiRNAs can bind to 3′UTR of target gene with micro response elements (MREs) and further inhibit the cellular function of target gene [32]. OGT was identified a target gene of miR-7-5p by multiple means, including qRT-PCR, luciferase reporter and RIP assays.…”
Section: Discussionmentioning
confidence: 99%
“…MTT, EdU, and plate colony formation assays were used to evaluate the ability of cell proliferation, as previously described 33 .…”
Section: Proliferation Assaysmentioning
confidence: 99%