miR-183 as a molecular and protective biomarker for cancer in schizophrenic subjects

Rizos, Emmanouil; Siafakas, Nikolaos; Koumarianou, Anna; Katsantoni, Eleni; Filippopoulou, Anastasia; Ntounas, P.; Touloumis, Ch.; Kastania, Anastasia N.; Zoumpourlis, Vassilis

doi:10.3892/or.2012.2052

Cited by 13 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miR-183 is a miRNA that has never been correlated with neurodegenerative diseases in the past, with the exception of a recent study where the possible suppressive role of miR-183 in the neurobiological pathways involved in schizophrenia was highlighted [15]. Mir183 has recently been implicated in modulation of different apoptotic and autophagic stages through regulation of apoptosis and autophagy-related genes [28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Let-7, MiR-98 and MiR-181 as Biomarkers for Cancer and Schizophrenia

Rizos

Siafakas

Papageorgiou

et al. 2015

European Psychiatry

Self Cite

View full text Add to dashboard Cite

Recent evidence supports a role of microRNAs in cancer and psychiatric disorders such as schizophrenia and bipolar disorder, through their regulatory role on the expression of multiple genes. The rather rare co-morbidity of cancer and schizophrenia is an old hypothesis which needs further research on microRNAs as molecules that might exert their oncosuppressive or oncogenic activity in the context of their role in psychiatric disorders. The expression pattern of a variety of different microRNAs was investigated in patients (N = 6) suffering from schizophrenia termed control, patients with a solid tumor (N = 10) and patients with both schizophrenia and tumor (N = 8). miRNA profiling was performed on whole blood samples using the miRCURY LNA microRNA Array technology (6th & 7th generation). A subset of 3 microRNAs showed a statistically significant differential expression between the control and the study groups. Specifically, significant down-regulation of the let7p-5p, miR-98-5p and of miR-183-5p in the study groups (tumor alone and tumorand schizophrenia) was observed (p<0.05). The results of the present study showed that let-7, miR-98 and miR-183 may play an important oncosuppressive role through their regulatory impact in gene expression irrespective of the presence of schizophrenia, although a larger sample size is required to validate these results. Nevertheless, further studies are warranted in order to highlight a possible role of these and other micro-RNAs in the molecular pathways of schizophrenia.

show abstract

Section: Discussionmentioning

confidence: 99%

Let-7, MiR-98 and MiR-181 as Biomarkers for Cancer and Schizophrenia

Rizos

Siafakas

Papageorgiou

et al. 2015

European Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Studies have reported that the expression levels of miR-183 and thymidine kinase (TK) 1 (TK1) in the peripheral blood of malignant carcinoma patients were significantly increased, suggesting their potential as serological markers for cancer diagnosis [9][10][11][12]. In this study, the expression levels of serum miR-183 https://doi.org/10.1515/biol-2017-0029…”

Section: Introductionmentioning

confidence: 73%

The diagnostic value of serum microRNA-183 and TK1 as biomarkers for colorectal cancer diagnosis

Zhu¹,

Wang²,

Chen³

2017

Open Life Sciences

View full text Add to dashboard Cite

ObjectiveTo evaluate the serum levels of microRNA-183 (miR-183) and thymidine kinase 1 (TK1) in colorectal cancer patients and their clinical value as biomarkers for colorectal cancer auxiliary diagnosis.MethodsForty-six pathology confirmed colorectal cancer patients and 46 healthy controls were included in this study. The serum levels of miR-183 and TK1 in colorectal cancer patients and healthy controls were examined by real-time PCR and chemiluminescence detection assay respectively. The diagnostic value of serum miR-183 and TK1 as tumor biomarkers for colorectal cancer detection was evaluated through receiver operating characteristic (ROC) curves.ResultsThe median serum relative expression of miR-183 was 1.33 (0.34-5.65) and 0.88 (0.26-4.67) in colorectal cancer patients and healthy controls respectively with significant statistical difference (p<0.05). Using serum miR-183 as the diagnostic reference, the colorectal cancer diagnosis sensitivity, specificity and AUC was 65.22%, 63.04% and 0.69 respectively. The median serum level of TK1 was 3.33 (0.78-5.78) pmol/L and 0.99 (0.34-4.46) pmol/L in colorectal cancer patients and healthy controls respectively with significant statistical difference (p<0.05). The diagnostic sensitivity, specificity and AUC was 84.78%, 78.26% and 0.88 respectively forserum TK1 as reference for colorectal diagnosis. The pearson correlation test was used to evaluate the serum miR-183 and TK1 correlation in colorectal cancer patients. However, no significant correlation between serum miR-183 and TK1 was found in colorectal patients (p>0.05).ConclusionSerum levels of miR-183 and TK1 arepotential biomarkers for colorectal cancer auxiliary diagnosis.

show abstract

“…Various studies have proved prominent roles of miRNAs in many physiological and pathological processes, and miRNAs could be a diagnostic and prognostic biomarker for various diseases such as cancer and CNS diseases including schizophrenia (Rao et al, 2013 ). Rizos et al ( 2012 ) found that miR-183 was upregulated in the group of persons with schizophrenia without cancer but was almost undetectable in the group of persons with schizophrenia with a solid tumor. Therefore, they proposed that miR-183 could be a protective biomarker for cancer in schizophrenic subjects (Rizos et al, 2012 ).…”

Section: The Similar Mechanisms Involved In Glioma Tumorigenesis and mentioning

confidence: 99%

Glioma in Schizophrenia: Is the Risk Higher or Lower?

Gao

Guo

et al. 2018

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Whether persons with schizophrenia have a higher or lower incidence of cancer has been discussed for a long time. Due to the complex mechanisms and characteristics of different types of cancer, it is difficult to evaluate the exact relationship between cancers and schizophrenia without considering the type of tumor. Schizophrenia, a disabling mental illness that is now recognized as a neurodevelopmental disorder, is more correlated with brain tumors, such as glioma, than other types of tumors. Thus, we mainly focused on the relationship between schizophrenia and glioma morbidity. Glioma tumorigenesis and schizophrenia may share similar mechanisms; gene/pathway disruption would affect neurodevelopment and reduce the risk of glioma. The molecular defects of disrupted-in-schizophrenia-1 (DISC1), P53, brain-derived neurotrophic factor (BDNF) and C-X-C chemokine receptors type 4 (CXCR4) involved in schizophrenia pathogenesis might play opposite roles in glioma development. Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia. Finally, antipsychotic drugs may have antitumor effects. All these factors show that persons with schizophrenia have a decreased incidence of glioma; therefore, epidemiological investigation and studies comparing genetic and epigenetic aberrations involved in both of these complex diseases should be performed. These studies can provide more insightful knowledge about glioma and schizophrenia pathophysiology and help to determine the target/strategies for the prevention and treatment of the two diseases.

show abstract

miR-183 as a molecular and protective biomarker for cancer in schizophrenic subjects

Cited by 13 publications

References 39 publications

Let-7, MiR-98 and MiR-181 as Biomarkers for Cancer and Schizophrenia

Let-7, MiR-98 and MiR-181 as Biomarkers for Cancer and Schizophrenia

The diagnostic value of serum microRNA-183 and TK1 as biomarkers for colorectal cancer diagnosis

Glioma in Schizophrenia: Is the Risk Higher or Lower?

Contact Info

Product

Resources

About