miR-183-5p attenuates the effect of sorafenib on human hepatocellular carcinoma via inhibiting SOCS6/JAK2/STAT3 pathway
Che Chen,
Yanyu Zhao,
Yanmei Song
et al.
Abstract:Objective:
MicroRNA plays a crucial role in the progression of hepatocellular carcinoma (HCC) and the resistance of HCC cells to sorafenib (SOR). Elevation of miR-183-5p is associated with poor survival among patients with HCC. This study aimed to investigate the impact of miR-183-5p on SOR resistance in HCC as well as its related signaling pathway. The objective is to provide new insights, directions, and a theoretical basis for the clinical diagnosis and treatment of HCC.
Design:
Human normal hepatocytes (… Show more
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