miR-17-5p and miR-20a-5p suppress postoperative metastasis of hepatocellular carcinoma via blocking HGF/ERBB3-NF-κB positive feedback loop

Serum exosomal microRNA‐766‐3p expression is associated with poor prognosis of esophageal squamous cell carcinoma

“…In addition, KEGG analysis showed that the endocytic pathway is altered in cancer cells, and these alterations contribute to increased receptor recycling, thereby enhancing invasiveness 29 . MicroRNAs play their roles by suppressing the expression of target genes 30,31 . The biological interactions between miRNAs and their target genes are very complex 32 .…”

CYP1A2 suppresses hepatocellular carcinoma through antagonizing HGF/MET signaling

“…Our data demonstrated that the reduction of CYP1A2 promoted the growth of HCC whereas its upregulation arrest the tumor progression. Emerging evidence has indicated that HGF/MET signaling plays a crucial role on tumor formation, development, maintenance, metastasis as well as the efficacy to systemic therapy, including sorafenib, in HCC 3 , 6 , 8 , 34 - 36 . Surprisingly, the anti-MET monotherapy, such as tivantinib, failed to show satisfactory outcomes in the phase III clinical trial 37 .…”

Construction of a 13‐microRNA‐based signature and prognostic nomogram for predicting overall survival in patients with hepatocellular carcinoma

“…[14][15][16] For example, miR-17-5p and miR-20a-5p could block hepatocyte growth factor/ERBB3-nuclear factor-κB positive feedback loop for hindering postoperative HCC metastasis and lengthening HCC patients' OS. 17 In addition, the overexpression of miR-552 promotes HCC tumorigenesis and cell proliferation. 18 The serum exo-miR-215-5p is highly expressed in HCC, and closely associates with disease-free survival of patients with HCC.…”

“…Moreover, some miRNAs facilitate cancer cell proliferation, growth, invasion, and metastasis 14–16 . For example, miR‐17‐5p and miR‐20a‐5p could block hepatocyte growth factor/ERBB3–nuclear factor‐κB positive feedback loop for hindering postoperative HCC metastasis and lengthening HCC patients’ OS 17 . In addition, the overexpression of miR‐552 promotes HCC tumorigenesis and cell proliferation 18 .…”