MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4

Sonkoly, Enikö; Janson, Peter; Majuri, Marja‐Leena; Savinko, Terhi; Fyhrquist, Nanna; Eidsmo, Liv; Xu, Ning; Meisgen, Florian; Wei, Tianling; Bradley, J. F. N.; Stenvang, Jan; Kauppinen, Sakari; Alenius, Harri; Lauerma, Antti; Homey, Bernhard; Winqvist, Ola; Ståhle, Mona; Pivarcsi, Andor

doi:10.1016/j.jaci.2010.05.045

Cited by 276 publications

(279 citation statements)

References 51 publications

(56 reference statements)

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Section: Introductionmentioning

confidence: 99%

“…Two studies found upregulation of miR-155, miR146a, miR-17-5p, and other miRNA in AD lesions, but downregulation of miR-122a, miR-326, miR-133b, and other miRNA [31,32]. miR-155 in Th cells from AD lesions was associated with enhanced cutaneous T-cell proliferative responses [31]. A study of keratinocytes from skin lesions of 10 humans with AD and 10 without AD found that promoter hypomethylation of the TSLP gene was associated with TSLP overexpression in AD lesions [33].…”

Section: Introductionmentioning

confidence: 99%

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Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

263

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

263

225

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“…The role of miRNAs in the pathogenesis of allergic asthma has been widely studied since 2007 (7)(8)(9)12,16,29) and therapies that target miRNAs were considered to be important for further study (30,31). The results of the present study indicate that miR-155 is associated with the development of allergic airway inflammation; miR-155 expression was significantly higher in the lungs of mice with asthma compared with normal controls.…”

Section: Discussionmentioning

confidence: 54%

“…Data from clinical samples support the theory that miR-155 serves a critical role in the pathogenesis of allergic diseases, including allergic rhinitis (14,15) and atopic dermatitis (16). In regards to the lungs, mice deficient in miR-155 exhibited enhanced airway remodelling (12) and miR-155 was demonstrated to contribute to the regulation of allergic airway inflammation by modulating Th2 responses through the transcription factor PU.1 (17).…”

Section: Introductionmentioning

confidence: 61%

Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma

Chen

Cheng

et al. 2017

Exp Ther Med

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Abstract. Asthma is a chronic T helper type 2 (Th2) cell-mediated inflammatory disease characterized by airway hyperresponsiveness (AHR) and airway inflammation. Although the majority of patients with asthma can achieve a good level of control with existing treatments, asthma runs a chronic course and the effectiveness of current treatment is not satisfactory for certain patients. MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the post-transcriptional level; their role in regulating allergic inflammation remains largely unknown. The present study aimed to explore the role of miRNA-155 in the pathogenesis of asthma and its potential as a target for treatment. The expression of miRNA-155 increased in ovalbumin-sensitized and challenged mice compared with control mice, and lentiviral vector-delivered small interfering (si)RNA targeting miRNA-155 resulted in reduced AHR, airway inflammation and Th2 cytokine production. The data from the present study indicate that miRNA-155 serves an important role in the pathogenesis of asthma, and that lentiviral vector-delivered siRNA targeting miRNA-155 may serve as a novel approach for the treatment of allergic asthma.

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“…42,88 In addition, Sonkoly et al found that miR-155 was one of the highest upregulated miRNAs in skin biopsies from patients with atopic dermatitis compared to healthy controls. 79 Topical exposure of non-lesional skin of atopic dermatitis patients with relevant allergens could induce miR-155 expression. MiR-155 is expressed by skin T cells, dendritic cells, and mast cells.…”

Section: Atopic Dermatitismentioning

confidence: 99%

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

2013

Journal of Allergy and Clinical Immunology

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Allergic inflammation is accompanied by the coordinated expression of a myriad of genes and proteins that initiate, sustain, and propagate immune responses and tissue remodeling. MicroRNAs (miRNAs) are a class of short single-stranded RNA molecules that post-transcriptionally silence gene expression and have been shown to fine-tune gene transcriptional networks as single miRNAs can target hundreds of genes. 7 Considerable attention has focused on the key role of miRNAs in regulating homeostatic immune architecture and acquired immunity. Recent studies have identified miRNA profiles in multiple allergic inflammatory diseases including asthma, eosinophilic esophagitis, allergic rhinitis, and atopic dermatitis. Specific miRNAs have been found to have critical roles in regulating key pathogenic mechanisms in allergic inflammation including polarization of adaptive immune responses and activation of T cells (e.g. miR-21 and miR-146), regulation of eosinophil development (e.g. miR-21 and miR-223), and modulation of interleukin (IL)-13-driven epithelial responses (e.g. miR-375). This review discusses recent advances in our understanding of the expression and function of miRNAs in allergic inflammation, their role as disease biomarkers, and perspectives for future investigation and clinical utility.

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MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4

Cited by 276 publications

References 51 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

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