miR-155 Accelerates the Growth of Human Liver Cancer Cells by Activating CDK2 via Targeting H3F3A

Xin, Xiaoru; Lu, Yanan; Xie, Sijie; Chen, Yingjie; Jiang, Xiaoxue; Song, Shuting; Wang, Liyan; Hu, Pu; Gui, Xin; Li, Tianming; Li, Jiao; Song, Jia; Lu, Dongdong

doi:10.1016/j.omto.2020.05.002

Cited by 16 publications

(11 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 36 Long noncoding RNA DUXAP8 promotes pancreatic carcinoma progression via the miR‐448/WTAP/Fak signaling axis 37 and miR‐155 accelerates the growth of human liver cancer cells by activating CDK2 via targeting H3F3A . 38 In addition, miR‐200c targets CDK2 and suppresses tumorigenesis in RCC. 39 These results suggest that miRNA, WTAP , and CDK2 are jointly involved in the progression of various tumors, which is consistent with our experimental results showing that miR‐501‐3p enhances the progression of RCC via the miR‐501‐3p/WTAP/CDK2 axis.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐501‐3p inhibits the proliferation of kidney cancer cells by targeting WTAP

Chen

Ying

et al. 2021

Cancer Medicine

View full text Add to dashboard Cite

Background: Emerging evidence suggests that miR-501-3p plays an important role in the pathogenesis and progression of various carcinomas. However, its role and underlying mechanisms in renal cell carcinoma (RCC) remain to be elucidated. Methods:Quantitative RT-PCR, western blot, and bioinformatics methods were used to evaluate the expression of miR-501-3p and Wilms' tumor 1-associating protein (WTAP) in RCC cell lines and clinical tissues. The effects of miR-501-3p on the proliferation of RCC cells were investigated using flow cytometric, colony formation, and CCK8 assays. The target gene of miR-501-3p was confirmed by western blotting, qRT-PCR, and dual-luciferase reporter assays. The levels of RNA methylation with N6-methyladenosine (m 6 A) following miR-501-3p overexpression or knockdown of its target gene were quantified using a dot-blot assay.Results: miR-501-3p expression was significantly downregulated in human RCC cell lines and tissues. In contrast, its overexpression markedly inhibited cancer cell proliferation in vitro by inducing G1 phase arrest. Moreover, WTAP was verified as a direct target gene of miR-501-3p. WTAP gene knockdown alone efficiently produced the same cancer-inhibiting effects as miR-501-3p overexpression, with the level of m 6 A in RCC cells being decreased under both scenarios.The intermolecular interaction between miR-501-3p and WTAP was further substantiated by rescue experiments. Conclusion:RCC progression is regulated via the miR-501-3p/WTAP/CDK2 axis and is inhibited by the overexpression of miR-501-3p.

show abstract

Section: Discussionmentioning

confidence: 99%

MicroRNA‐501‐3p inhibits the proliferation of kidney cancer cells by targeting WTAP

Chen

Ying

et al. 2021

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…Nonetheless, no further analyses were performed in this study to assess the impact of miR-155 in Hep3b aggressiveness. A recent study has demonstrated that miR-155 plays a pro-tumoral role in hepatocarcinogenesis through the inhibition of H3F3A expression and H3K27 methylation, which blocks the expression of the P21WAF1/CIP1 tumor suppressor gene [103]. Similarly, the downregulation of miR-122 has been found to be related to Sorafenib resistance in liver cancer cells [104].…”

Section: Non-coding Rnas Small Rnasmentioning

confidence: 98%

Role of Nitric Oxide in Gene Expression Regulation during Cancer: Epigenetic Modifications and Non-Coding RNAs

Cruz‐Ojeda

Flores-Campos

Dios-Barbeito

et al. 2021

IJMS

View full text Add to dashboard Cite

Nitric oxide (NO) has been identified and described as a dual mediator in cancer according to dose-, time- and compartment-dependent NO generation. The present review addresses the different epigenetic mechanisms, such as histone modifications and non-coding RNAs (ncRNAs), miRNA and lncRNA, which regulate directly or indirectly nitric oxide synthase (NOS) expression and NO production, impacting all hallmarks of the oncogenic process. Among lncRNA, HEIH and UCA1 develop their oncogenic functions by inhibiting their target miRNAs and consequently reversing the inhibition of NOS and promoting tumor proliferation. The connection between miRNAs and NO is also involved in two important features in cancer, such as the tumor microenvironment that includes key cellular components such as tumor-associated macrophages (TAMs), cancer associated fibroblasts (CAFs) and cancer stem cells (CSCs).

show abstract

“…Other risk factors include chemical carcinogens exposure, obesity, diabetes, and alcohol abuse (Fig. 1C) [10][11][12][13], and the HCC incidence has been on the rise in recent years. Meanwhile, there are significant geographical differences in the risk factors for HCC, mirroring the variation in global distribution patterns.…”

Section: Current Epidemiology Of Hccmentioning

confidence: 99%

The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma

et al. 2021

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide due to its high degree of malignancy, high incidence, and low survival rate. However, the underlying mechanisms of hepatocarcinogenesis remain unclear. Long non coding RNA (lncRNA) has been shown as a novel type of RNA. lncRNA by acting as ceRNA can participate in various biological processes of HCC cells, such as tumor cell proliferation, migration, invasion, apoptosis and drug resistance by regulating downstream target gene expression and cancer-related signaling pathways. Meanwhile, lncRNA can predict the efficacy of treatment strategies for HCC and serve as a potential target for the diagnosis and treatment of HCC. Therefore, lncRNA serving as ceRNA may become a vital candidate biomarker for clinical diagnosis and treatment. In this review, the epidemiology of HCC, including morbidity, mortality, regional distribution, risk factors, and current treatment advances, was briefly discussed, and some biological functions of lncRNA in HCC were summarized with emphasis on the molecular mechanism and clinical application of lncRNA-mediated ceRNA regulatory network in HCC. This paper can contribute to the better understanding of the mechanism of the influence of lncRNA-mediated ceRNA networks (ceRNETs) on HCC and provide directions and strategies for future studies.

show abstract

miR-155 Accelerates the Growth of Human Liver Cancer Cells by Activating CDK2 via Targeting H3F3A

Cited by 16 publications

References 54 publications

MicroRNA‐501‐3p inhibits the proliferation of kidney cancer cells by targeting WTAP

MicroRNA‐501‐3p inhibits the proliferation of kidney cancer cells by targeting WTAP

Role of Nitric Oxide in Gene Expression Regulation during Cancer: Epigenetic Modifications and Non-Coding RNAs

The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma

Contact Info

Product

Resources

About