2011
DOI: 10.1038/cdd.2011.28
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MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer

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Cited by 182 publications
(155 citation statements)
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References 36 publications
(36 reference statements)
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“…36 Generally, miR-148a functions as a tumor suppressor in cancer cells. [33][34][35][36] However, in most studies, miR-148a was detected in specimens of tissues or cell lines. There is limited research involving exosomes containing miR-148a.…”
Section: Discussionmentioning
confidence: 99%
“…36 Generally, miR-148a functions as a tumor suppressor in cancer cells. [33][34][35][36] However, in most studies, miR-148a was detected in specimens of tissues or cell lines. There is limited research involving exosomes containing miR-148a.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have indicated that HLA-G expression level may be regulated by miR-148a, and that miR-148b and HLA-G were upregulated in primary ESCC tissues (13,16). Based on these reports, it was hypothesized that miR-148a may contribute to the proliferation of ESCC cells by regulating HLA-G expression.…”
Section: Effect Of Mir-148a On Hla-g Expressionmentioning
confidence: 99%
“…MiRs are also key regulators of gene transcription, and are frequently involved in the occurrence of cancers (9). In particular, miR-148a has been reported to be a tumor suppressor in multiple cancer types, including gastrointestinal (10), breast (11), ovarian (12), colorectal (13) and prostate cancer (14). Hummel et al (15) reported that miR-148a was downregulated in patients with recurrent EC.…”
Section: Introductionmentioning
confidence: 99%
“…Previous research described miR-148a as a tumor suppressor in hepatocellular carcinoma, pancreatic cancer, gastric cancer and colorectal cancer. It was shown that microRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer [181], promotes apoptosis by targeting Bcl-2 in colorectal cancer [182], and suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling [179]. However, we were not able to verify the above as targets of miR-148a in GBM.…”
Section: Mir-148a Inhibits Egfr Trafficking and Degradationmentioning
confidence: 69%
“…A thorough literature analysis revealed no publications on miR-148a in GBM. Previous published research had described miR-148a as a tumor suppressor in hepatocellular carcinoma, pancreatic cancer, gastric cancer and colorectal cancer [179][180][181][182]. However, a role for miR-148a in GBM and its characterization as oncogene have not been described before.…”
Section: Introductionmentioning
confidence: 99%