miR-146a promotes cell migration and invasion in melanoma by directly targeting SMAD4

Pu, Wei; Shang, Yongming; Shao, Qiang; Yuan, Xinpeng

doi:10.3892/ol.2018.8172

Cited by 18 publications

(24 citation statements)

References 27 publications

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“…Other investigators confirmed using transwell assays that miR‐146a could also promote malignant melanoma migration and invasion. SMAD4 was targeted by miR‐146a in these cells, and ectopically expressing SMAD4 could block the effects of the miRNA on migration and invasion (Pu et al, ). Overall, miR‐146a can affect multiple signaling pathways in melanoma cells, including Notch and TGF‐β.…”

Section: Role Of Mir‐146a In Specific Cancersmentioning

confidence: 99%

miR‐146a‐5p: Expression, regulation, and functions in cancer

2019

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Cancer as we know it is actually an umbrella term for over 100 very unique malignancies in various tissues throughout the human body. Each type, and even subtype of cancer, has different genetic, epigenetic, and other cellular events responsible for malignant development and metastasis. Recent work has indicated that microRNAs (miRNAs) play a major role in these processes, sometimes by promoting cancer growth and other times by suppressing tumorigenesis. miRNAs are small, noncoding RNAs that negatively regulate expression of specific target genes. This review goes into an in‐depth look at the most recent finding regarding the significance of one particular miRNA, miR‐146a‐5p, and its involvement in cancer. Target gene validation and pathway analysis have provided mechanistic insight into this miRNA's purpose in assorted tissues. Additionally, this review outlines novel findings that suggest miR‐146a‐5p may be useful as a noninvasive biomarker and as a targeted therapeutic in several cancers. This article is categorized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs

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Section: Role Of Mir‐146a In Specific Cancersmentioning

confidence: 99%

miR‐146a‐5p: Expression, regulation, and functions in cancer

2019

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“…It's a part of transforming growth factor-beta (TGF-β) signaling pathway by activating SMAD proteins forming a complex with SMAD4 protein. As a central mediator of TGF-β signaling, SMAD4 plays a role in cell differentiation, migration, invasion, and apoptosis [47]. Mouse models suggest that SMAD-mediated signaling in melanoma can play various functions, such as the proliferation of melanoma cells [48].…”

Section: Smad4mentioning

confidence: 99%

Mutation profile of primary subungual melanomas in Caucasians

et al. 2020

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Background: Specific genomic profile of cutaneous melanomas is related to UVR exposure, which exerts biological and therapeutic impact. Subungual melanoma (SUM) is an exceedingly rare disease; therefore, it is not well characterized. SUM pathogenesis is not related to UVR induced DNA damage and expected to differ from other melanoma subtypes. Our study aimed to define the mutation profile of SUM in Caucasians. Materials and Methods: Next-generation sequencing-based genomic analysis was used to identify frequently mutated loci in 50 cancer-related genes in 31 SUM primary tumors. Results: The most abundant mutations in SUM were found in KIT-in 13% of cases and NRAS-also in 13%, while BRAF-only in 3% of cases. Conclusions: Our findings confirmed a high frequency of KIT and NRAS mutations in SUM, as well as a low incidence of BRAF mutations. We reported novel KRAS, CTNNB1, TP53, ERBB2, and SMAD4 mutations in SUM. Our findings provide new insights into the molecular pathogenesis of SUM.

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“…In our present study, DEMs analysis found that miR-146a and miR-153b were both more highly detected in TM compared to those in WT. In mammals, recent studies have reported that miR-146a played an important role in melanoma [39,40,41] and retinal pigment epithelial cells [42]. Similarly, miR-153 could suppress cell proliferation and invasion by targeting snail family transcriptional repressor 1 (SNAI1) in melanoma [43].…”

Section: Discussionmentioning

confidence: 99%

Genetic Characteristic and RNA-Seq Analysis in Transparent Mutant of Carp–Goldfish Nucleocytoplasmic Hybrid

Zhou

Liang

Zhou

et al. 2019

Genes

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In teleost, pigment in the skin and scales played important roles in various biological processes. Iridophores, one of the main pigment cells in teleost, could produce silver pigments to reflect light. However, the specific mechanism of the formation of silver pigments is still unclear. In our previous study, some transparent mutant individuals were found in the carp–goldfish nucleocytoplasmic hybrid (CyCa hybrid) population. In the present study, using transparent mutants (TM) and wild type (WT) of the CyCa hybrid as a model, firstly, microscopic observations showed that the silver pigments and melanin were both lost in the scales of transparent mutants compared to that in wild types. Secondly, genetic study demonstrated that the transparent trait in the CyCa hybrid was recessively inherent, and controlled by an allele in line with Mendelism. Thirdly, RNA-Seq analysis showed that differential expression genes (DEGs) between wild type and transparent mutants were mainly enriched in the metabolism of guanine, such as hydrolase, guanyl nucleotide binding, guanyl ribonucleotide binding, and GTPase activity. Among the DEGs, purine nucleoside phosphorylase 4a (pnp4a) and endothelin receptor B (ednrb) were more highly expressed in the wild type compared to the transparent mutant (p < 0.05). Finally, miRNA-Seq analysis showed that miRNA-146a and miR-153b were both more highly expressed in the transparent mutant compared to that in wild type (p < 0.05). Interaction analysis between miRNAs and mRNAs indicated that miRNA-146a was associated with six DEGs (MGAT5B, MFAP4, GP2, htt, Sema6b, Obscn) that might be involved in silver pigmentation.

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miR-146a promotes cell migration and invasion in melanoma by directly targeting SMAD4

Cited by 18 publications

References 27 publications

miR‐146a‐5p: Expression, regulation, and functions in cancer

miR‐146a‐5p: Expression, regulation, and functions in cancer

Mutation profile of primary subungual melanomas in Caucasians

Genetic Characteristic and RNA-Seq Analysis in Transparent Mutant of Carp–Goldfish Nucleocytoplasmic Hybrid

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