MiR-145 modulates the radiosensitivity of non-small cell lung cancer cells by suppression of TMOD3

Li, Hang; Zhao, Shuya; Chen, Xin; Feng, Guoxing; Chen, Zhiyuan; Fan, Songqing

doi:10.1093/carcin/bgab121

Cited by 14 publications

(14 citation statements)

References 41 publications

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“…The SPSS 26.0 software was used for statistical analysis of the data involved in this study, and the measurement data were verified [ 24 ]. After confirming that the data were normally distributed, mean ± standard deviation (‾ x ± s ) was used to represent the data differences between groups, and a t -test was performed.…”

Section: Methodsmentioning

confidence: 99%

[Retracted] Study on the Predictive Value of P53 Protein Expression in Brain Metastasis in NSCLC and the Mechanism of miR‐424 Reversing Platinum Resistance in NSCLC

Yan

Duan

Luo

et al. 2022

Contrast Media & Molecular Imaging

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In order to analyze the predictive value of P53 protein expression in brain metastases in NSCLC and the mechanism of miR-424 reversing platinum resistance in NSCLC, a retrospective analysis is conducted in this study. Eighty-two NSCLC patients who received relevant diagnosis and treatment in our hospital from September 2020 to September 2021 are chosen. The prognosis of the patients is observed, and the patients were divided into two groups according to the occurrence of BMS. The comparison of clinical baseline data and the expression of P53 protein and miR-424 after surgery are performed. Furthermore, the predictive value of the P53 protein gene on the occurrence of BMS in NSCLC is analyzed by the ROC curve, and the expression of miR-424 in serum of the patients before and after drug resistance is compared. The results demonstrate that the expression of P53 protein has a high predictive value for predicting the occurrence of BRAIN metastases in NSCLC patients. Also, the high expression of miR-424 suggests that it is closely related to the occurrence of platinum resistance in NSCLC patients.

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Section: Methodsmentioning

confidence: 99%

[Retracted] Study on the Predictive Value of P53 Protein Expression in Brain Metastasis in NSCLC and the Mechanism of miR‐424 Reversing Platinum Resistance in NSCLC

Yan

Duan

Luo

et al. 2022

Contrast Media & Molecular Imaging

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“…Additionally, functional experiments showed that miR-145-5p attenuated proliferation, migration and invasion in the Eca109 cell line. In fact, much evidence has revealed that miR-145-5p functioned as a tumor suppressor and that the expression levels of miR-145-5p were extremely downregulated in certain types of cancers to avoid antioncogenic functions ( 10 , 17 , 19 - 21 ). The results of our study also show that the miR-145-5p level is significantly associated with the progression of ESCC.…”

Section: Discussionmentioning

confidence: 99%

The role of miR-145-5p in esophageal squamous cell carcinoma tumor-associated macrophages and selection of immunochemotherapy

Lin¹,

Wu²,

Zhu³

et al. 2022

J Thorac Dis

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Background The impact of miR-145-5p in immune infiltration and the potential application in esophageal squamous cell carcinoma (ESCC) immunochemotherapy remains unknown. Methods Transcriptomic data for ESCC tissues and normal tissues and clinical materials of patients with ESCC were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. The differences in mRNA levels in cancer tissues and noncancerous tissues were analyzed, and we subsequently investigated the association between miR-145-5p expression and the key parameters of ESCC progression and prognosis. Additionally, cytological experiments were performed to evaluate the biological functions of miR-145-5p. Pathways potentially affected by miR-145-5p were analyzed by Gene Set Enrichment Analysis (GSEA) and REACTOME. We also analyzed the function of miR-145-5p in immune infiltration through the TIMER2 (Tumor Immune Estimation Resource) database. Results The analysis of gene chip data from the TCGA database and GEO database (including GSE13937 and GSE43732) showed that the expression of miR-145-5p is downregulated in ESCC (P<0.05) and that patients with high miR-145-5p levels had lower survival rates (P<0.05). The expression of miR-145-5p was significantly correlated with the disease-free survival (DFS) rate (P<0.05) and M stage (P<0.05) in the TCGA database and was significantly correlated with the T stage (P<0.05) and TNM stage (P<0.05) in the GSE13937 database. Functional experiments showed that miR-145-5p attenuated proliferation (P<0.05), migration (P<0.01) and invasion (P<0.01) in the Eca109 cell line. Both GSEA gene enrichment and REACTOME gene enrichment revealed that miR-145-5p was associated with tumor signaling pathways and immune signaling pathways. Immune infiltration analysis revealed that the expression level of miR-145-5p was significantly correlated with the infiltration level of macrophages (P<0.05) and was positively correlated with the level of gene markers of M2 macrophages and tumor-associated macrophages (P<0.05). Conclusions MiR-145-5p acts as a tumor suppressor microRNA in ESCC and is an important noncoding RNA in the high M2-like tumor-associated macrophage infiltration of ESCC. Assessing the miR-145-5p level in ESCC samples has translational meaning, which help illustrate the immune infiltration status, predict the prognostic outcome, and select the type of immunochemotherapy.

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“…In this work, the authors investigated the role of miR-145-5p in the regulation of ADP ribosylation factors 6 (ARF6) in the tumorigenesis of UTUC. MiR-145-5 p is a well-studied tumor suppressor microRNA, which is downregulated in many cancers [ 209 ] and it is related to poor prognosis in prostate, gastric, cervical, glioblastoma and non-small cell lung carcinoma (NSCLC) [ 210 , 211 , 212 , 213 , 214 ]. ADP-ribosylation factor 6 (ARF6), expressed widely in mammalian cells, is a small protein that is involved in several biological mechanisms, such as membrane trafficking and actin cytoskeletal rearrangement [ 215 ].…”

Section: Promising Microrna Biomarkers In Utucmentioning

confidence: 99%

MicroRNA Signatures in the Upper Urinary Tract Urothelial Carcinoma Scenario: Ready for the Game Changer?

Cinque

Capasso

Vago

et al. 2022

IJMS

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Upper urinary tract urothelial carcinoma (UTUC) represents a minor subgroup of malignancies arising in the urothelium of the renal pelvis or ureter. The estimated annual incidence is around 2 cases per 100,000 people, with a mean age at diagnosis of 73 years. UTUC is more frequently diagnosed in an invasive or metastatic stage. However, even though the incidence of UTUC is not high, UTUC tends to be aggressive and rapidly progressing with a poor prognosis in some patients. A significant challenge in UTUC is ensuring accurate and timely diagnosis, which is complicated by the non-specific nature of symptoms seen at the onset of disease. Moreover, there is a lack of biomarkers capable of identifying the early presence of the malignancy and guide-tailored medical treatment. However, the growing understanding of the molecular biology underlying UTUC has led to the discovery of promising new biomarkers. Among these biomarkers, there is a class of small non-coding RNA biomarkers known as microRNAs (miRNAs) that are particularly promising. In this review, we will analyze the main characteristics of UTUC and focus on microRNAs as possible novel tools that could enter clinical practice in order to optimize the current diagnostic and prognostic algorithm.

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MiR-145 modulates the radiosensitivity of non-small cell lung cancer cells by suppression of TMOD3

Cited by 14 publications

References 41 publications

[Retracted] Study on the Predictive Value of P53 Protein Expression in Brain Metastasis in NSCLC and the Mechanism of miR‐424 Reversing Platinum Resistance in NSCLC

[Retracted] Study on the Predictive Value of P53 Protein Expression in Brain Metastasis in NSCLC and the Mechanism of miR‐424 Reversing Platinum Resistance in NSCLC

The role of miR-145-5p in esophageal squamous cell carcinoma tumor-associated macrophages and selection of immunochemotherapy

MicroRNA Signatures in the Upper Urinary Tract Urothelial Carcinoma Scenario: Ready for the Game Changer?

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