“…The receptor tyrosine kinases (RTKs) signaling pathway effect many signals, including epidermal growth factor (EGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), insulin-like growth factor (IGF) and their receptors, as well as intracellular signaling pathways, such as mitogen-activated protein kinases (MAPKs) and phosphatidylinositol 3-kinase (PI3K). The dysregulation of miRNAs on the RTK signaling pathway is play important roles in ESCC metastasis[ 10 , 12 , 13 , 15 , 23 , 24 , 26 , 30 - 33 , 36 , 39 , 44 , 50 , 53 , 62 , 63 , 66 , 69 , 70 - 73 , 76 - 78 , 80 , 81 , 83 , 85 , 86 , 88 - 91 , 93 , 95 , 97 , 100 - 104 , 107 - 109 , 112 , 117 , 123 , 125 , 128 , 140 - 144 , 146 , 151 , 154 , 160 , 163 , 169 , 174 , 175 , 178 - 180 , 185 - 187 , 189 , 192 , 193 , 195...…”