MiR-144 suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting &lt;em&gt;SMAD4&lt;/em&gt;

Yu, Min; Lin, Ye; Zhou, Yu; Jin, Haosheng; Hou, Baohua; Wu, Zhongshi; Li, Zhide; Jian, Zhixiang; Sun, Jian

doi:10.2147/ott.s88233

Cited by 34 publications

(29 citation statements)

References 24 publications

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“…Yu M et al assessed the role of miR-144 in HCC. They found that the expression of miR-144 was regularly downregulated in human HCC tissues and cell lines, and the overexpression of miR-144 via direct targeting of SMAD4 significantly repressed metastasis, invasion, cell cycle, EMT, and resistance to chemotherapy [95]. Lu et al proposed that the upregulation of miR-144 through direct targeting of taurine upregulated gene 1 (TUG1) contributed to the inactivation of the JAK2/STAT3 pathway, impairing proliferation, migration, and tumorigenesis in HCC [96].…”

Section: Mir-144 In Hepatocellular Carcinomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.Int. J. Mol. Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers. More than 50% of miRNA genes were discovered to be located within the genomic regions that are involved in cancers, suggesting their role in human cancer pathogenesis. In pathological conditions, MiRNAs can negatively regulate gene expression and they are associated with tumor growth, apoptosis, invasion, and metastasis. In the past, several studies have indicated the ability of miRNAs in the inhibition of tumors as a critical option for the improvement of cancer therapy [4,5]. Tumor activator miRNAs, called oncomiRs, are overexpressed in various cancers. On the contrary, suppressive tumor miRNAs are underexpressed [6][7][8]. Among several miRNAs assessed, miR-144s seem to have a role in several cancers. These miRNAs are located in the chromosomal region 17q11.2, being significantly destroyed in many types of cancers. The predicted stem-loop structure of miR-144s recognized by the miRBase (http://mirbase.org/) is shown in Figure 1A. The miR-144 hairpin gives rise to the "guide strand" miR-144-5p and the sister "passenger" strand miR-144-3p ( Figure 1B).

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Section: Mir-144 In Hepatocellular Carcinomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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“…With regard to miR-144-3p expression in HCC, there have been only three individual studies which focused on miR-144-3p expression in HCC tissues with small sample size. Zhou et al,30 Cao et al31 and Yu et al29 unveiled that miR-144-3p was downregulated in 23 pairs, 33 pairs and 100 pairs of HCC tissues with corresponding normal control tissues, respectively. Likewise, we observed a decreased miR-144-3p level both in TCGA data and in qRT-PCR validation (both P <0.001).…”

Section: Discussionmentioning

confidence: 98%

“…Regarding the clinicopathologic significance of miR-144-3p in HCC, only Yu et al carried out the analysis unveiling that downregulated miR-144-3p was more remarkable in advanced TNM stage compared to early TNM stage 29. In this study, we observed miR-144-3p level was lower in metastasis ( P =0.006), advanced TNM stage ( P =0.001) and noncapsule or infiltration ( P =0.047) groups than in non-metastasis, early TNM stage and complete capsule groups, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Cao et al ascertained miR-144-3p could suppress the cell proliferation, migration and invasion in HCC by directly targeting E2F transcription factor 3 in vitro 31. From the perspective of the biologic process of miRNA with multiple targets, Yu et al clarified another target (SMAD family member 4, SMAD4 ) of miR-144-3p in HCC and showed that miR-144-3p could increase the chemosensitivity of 5-fluorouracil in HCC cell line 29. Similarly, Zhou et al elucidated that miR-144-3p could enhance the chemosensitivity through the regulation of Nrf2-dependent antioxidant pathway 30.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been reported that miRNAs can play an indispensable role in the pathogenesis of cancers through the regulation of oncogene and anti-oncogene 20–28. There have been three published articles that investigated miR-144-3p level in HCC tissue with small sample size, and all of them showed downregulation of miR-144-3p expression in HCC 29–31. However, the limited sample size of the three individual studies (23 pairs, 33 pairs and 100 pairs, respectively) may lead to false-positive results and a weak conclusion.…”

Section: Introductionmentioning

confidence: 99%

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A comprehensive insight into the clinicopathologic significance of miR-144-3p in hepatocellular carcinoma

Liang¹,

Ye²,

Yin³

et al. 2017

OTT

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BackgroundStudies which focused on the character of miR-144-3p in hepatocellular carcinoma (HCC) are limited. This study aimed to explore the expression, clinical significance and the potential targets of miR-144-3p in HCC.MethodsThe Cancer Genome Atlas (TCGA) and a cohort of 95 cases of HCC were applied to investigate aberrant miR-144-3p expression in HCC. A meta-analysis was performed to accumulate data on miR-144-3p expression in HCC based on TCGA, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Gene Expression Omnibus (GEO). Additionally, the potential regulatory mechanisms of miR-144-3p in HCC were explored by bioinformatics.ResultsMiR-144-3p expression was downregulated distinctly in HCC compared to para-HCC tissue both in TCGA data (8.9139±1.5986 vs 10.7721±0.9156, P<0.001) and in our qRT-PCR validation (1.3208±0.7594 vs 2.6200±0.9263, P<0.001). The meta-analysis based on TCGA, qRT-PCR and GEO data confirmed a consistent result (standard mean difference =−0.854, 95% CI: −1.224 to −0.484, P<0.001). The receiver operating characteristic curve of miR-144-3p gained a significant diagnostic value both in TCGA data (area under the curve [AUC] =0.852, 95% CI: 0.810 to 0.894, P<0.001) and in qRT-PCR validation (AUC =0.867, 95% CI: 0.817 to 0.916, P<0.001), especially in alpha-fetoprotein–negative HCC patients (AUC =0.900, 95% CI: 0.839 to 0.960, P<0.001). Furthermore, we identified 119 potential targets of miR-144-3p in HCC by bioinformatics. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that several significant biologic functions and pathways correlated with the pathogenesis of HCC, including the p53 signaling pathway.ConclusionMiR-144-3p may function as a cancer suppressor microRNA, which is essential for HCC progression through the regulation of various signaling pathways. Thus, interactions with miR-144-3p may provide a novel treatment strategy for HCC in the future.

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MicroRNA‐144‐3p controls the apoptosis of pulmonary artery endothelial cells in pulmonary arterial hypertension via the BMPR2/Smad4 signaling pathway

Shi

Rahman

Liu

et al. 2022

Clinical and Translational Dis

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MiR-144 suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting <em>SMAD4</em>

Cited by 34 publications

References 24 publications

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

A comprehensive insight into the clinicopathologic significance of miR-144-3p in hepatocellular carcinoma

MicroRNA‐144‐3p controls the apoptosis of pulmonary artery endothelial cells in pulmonary arterial hypertension via the BMPR2/Smad4 signaling pathway

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