MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression

Sun, Lei; Bian, Guang-Qing; Meng, Zhaojun; Dang, Guangfu; Shi, Dejing; Mi, Shuyong

doi:10.1371/journal.pone.0124428

Cited by 44 publications

(47 citation statements)

References 53 publications

(39 reference statements)

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“…Increasing evidences demonstrate that miRNAs have a regulatory role in the development and progression of human cancers through the suppression of genes involved in cell proliferation, differentiation, invasion and migration [32][33][34][35][36][37][38][39]. Our previous study has shown that miR-144 acts as a tumor suppressor in uveal melanoma [40]. Moreover, Liu et al demonstrated that miR-9 suppressed uveal melanoma cell migration and invasion partly through downregulation of the NF-jB1 signaling pathway [8].…”

Section: Discussionmentioning

confidence: 99%

Retracted: MicroRNA‐454 functions as an oncogene by regulating PTEN in uveal melanoma

et al. 2015

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Edited by Tamas Dalmay Keywords:Uveal melanoma MicroRNA miR-454 PTEN a b s t r a c t MicroRNAs (miRNAs) regulate gene expression by targeted repression of transcription and translation, and are involved in carcinogenesis. In this study, we demonstrated that the expression of miR-454 was up-regulated in uveal melanoma tissues compared to normal tissues. Ectopic expression of miR-454 resulted in significant promotion of cell proliferation, colony formation, invasion and induction of cell cycle in uveal melanoma cells. Furthermore, we identified PTEN as a direct target of miR-454. Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells. These findings support an oncogene role of miR-454 in development of uveal melanoma.

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Section: Discussionmentioning

confidence: 99%

Retracted: MicroRNA‐454 functions as an oncogene by regulating PTEN in uveal melanoma

et al. 2015

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“…The down-regulation of miR-144 through targeting of SMAD1 has a regulatory effect on cell proliferation and metastasis in melanoma [173]. Furthermore, miR-144 suppresses the proliferation and invasion of melanoma cells by regulating c-Met expression [174].…”

Section: Mir-144 In Melanomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.Int. J. Mol. Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers. More than 50% of miRNA genes were discovered to be located within the genomic regions that are involved in cancers, suggesting their role in human cancer pathogenesis. In pathological conditions, MiRNAs can negatively regulate gene expression and they are associated with tumor growth, apoptosis, invasion, and metastasis. In the past, several studies have indicated the ability of miRNAs in the inhibition of tumors as a critical option for the improvement of cancer therapy [4,5]. Tumor activator miRNAs, called oncomiRs, are overexpressed in various cancers. On the contrary, suppressive tumor miRNAs are underexpressed [6][7][8]. Among several miRNAs assessed, miR-144s seem to have a role in several cancers. These miRNAs are located in the chromosomal region 17q11.2, being significantly destroyed in many types of cancers. The predicted stem-loop structure of miR-144s recognized by the miRBase (http://mirbase.org/) is shown in Figure 1A. The miR-144 hairpin gives rise to the "guide strand" miR-144-5p and the sister "passenger" strand miR-144-3p ( Figure 1B).

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“…PTEN is a well-known antioncogene, and exerts a tumor-suppressive effect during uveal melanoma pathogenesis (Abdel-Rahman et al, 2006;Sun et al, 2015a). Moreover, loss of PTEN expression is associated with shortened disease-free survival of uveal melanoma patients (AbdelRahman et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Many well-known oncogenes and tumor-suppressor genes have been confirmed to be direct targets of various miRNAs, the crucial role of which in cancer development has been widely recognized (Shenouda and Alahari, 2009;Kanekura et al, 2016;Lee et al, 2016). miR-144, miR-34a, and miR-32 inhibit uveal melanoma cell proliferation and migration by regulating c-Met and EZH2 (Yan et al, 2009;Sun et al, 2015a;Ma et al, 2016), whereas miR-454 functions as an oncogene due to its effect on PTEN (Sun et al, 2015b). Achberger et al (2014) reported that uveal melanoma patients with and without metastasis exhibit different plasma miRNA expression patterns.…”

Section: Introductionmentioning

confidence: 99%

Research Article miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN.

Ling

Zhang

et al. 2017

Genet. Mol. Res.

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ABSTRACT. We aimed to investigate the biological role of miR-367 in uveal melanoma cell growth and migration, and the underlying mechanism responsible. Quantitative real-time polymerase chain reaction was performed to evaluate miR-367 expression in uveal melanoma tissue samples and cell lines. A miR-367 mimic, miR-367 inhibitor, and negative control oligonucleotide were transfected into these cells to investigate the function of this microRNA. In addition, the role of PTEN in miR-367-mediated uveal melanoma cell growth and migration was evaluated. miR-367 was significantly upregulated in uveal melanoma cells and tissue samples (both P < 0.01). Its inhibition suppressed the proliferation, cell cycle transition, and migration of such cells, and increased levels had the opposite effect. PTEN was confirmed to be a target gene of miR-367. More importantly, co-transfection with a PTEN construct lacking the 3'-untranslated region mitigated miR-367 mimic-induced promotion of uveal melanoma cell proliferation and migration. In summary, miR-367 was found to be upregulated in this malignancy, and may promote uveal melanoma cell proliferation and migration, at least in part by regulating PTEN.

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MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression

Cited by 44 publications

References 53 publications

Retracted: MicroRNA‐454 functions as an oncogene by regulating PTEN in uveal melanoma

Retracted: MicroRNA‐454 functions as an oncogene by regulating PTEN in uveal melanoma

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Research Article miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN.

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