MiR-144-5p and miR-21-5p do not drive bone disease in a mouse model of type 1 diabetes mellitus
Souad Daamouch,
Matthias Blüher,
David Carro Vázquez
et al.
Abstract:The increased risk of fractures in patients with type 1 diabetes mellitus (T1DM) is nowadays well recognized. However, the exact mechanism of action of diabetic bone disease has not been fully elucidated. MicroRNAs (miRNAs) are gene regulators that operate post-transcriptionally and have been implicated in the development of various metabolic disorders including T1DM. Previous studies have implicated a role for miR-144-5p and miR-21-5p, which are involved in controlling oxidative stress by targeting Nrf2, in T… Show more
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