miR-144/451 in hematopoiesis and beyond

Wang, Ting; Wu, Fan; Yu, Duonan

doi:10.1186/s41544-019-0035-8

Cited by 24 publications

(21 citation statements)

References 109 publications

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“…These dynamic changes in expression of key variables (miR-451, LKB1, AMPK, OCT1) in various conditions are in good agreement with experimental observations (U252 in [14]). In particular, these theoretical predictions from our model and experimental data [14] show the important role of OCT1 (figure 3b,h) in regulation of glioma invasion and for developing therapeutic strategies [67][68][69].…”

Section: (C) Dynamics Of the Core Control Systemsupporting

confidence: 69%

Collective invasion of glioma cells through OCT1 signalling and interaction with reactive astrocytes after surgery

Kim

Lee

Lawler

2020

Phil. Trans. R. Soc. B

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Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with a short median survival time. GBM is characterized by the hallmarks of aggressive proliferation and cellular infiltration of normal brain tissue. miR-451 and its downstream molecules are known to play a pivotal role in regulation of the balance of proliferation and aggressive invasion in response to metabolic stress in the tumour microenvironment (TME). Surgery-induced transition in reactive astrocyte populations can play a significant role in tumour dynamics. In this work, we develop a multi-scale mathematical model of miR-451-LKB1-AMPK-OCT1-mTOR pathway signalling and individual cell dynamics of the tumour and reactive astrocytes after surgery. We show how the effects of fluctuating glucose on tumour cells need to be reprogrammed by taking into account the recent history of glucose variations and an AMPK/miR-451 reciprocal feedback loop. The model shows how variations in glucose availability significantly affect the activity of signalling molecules and, in turn, lead to critical cell migration. The model also predicts that microsurgery of a primary tumour induces phenotypical changes in reactive astrocytes and stem cell-like astrocytes promoting tumour cell proliferation and migration by Cxcl5. Finally, we investigated a new anti-tumour strategy by Cxcl5-targeting drugs. This article is part of the theme issue ‘Multi-scale analysis and modelling of collective migration in biological systems’.

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Section: (C) Dynamics Of the Core Control Systemsupporting

confidence: 69%

Collective invasion of glioma cells through OCT1 signalling and interaction with reactive astrocytes after surgery

Kim

Lee

Lawler

2020

Phil. Trans. R. Soc. B

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“…MiR-451a (or miR-451, miRBase 22) is dicer independent and can be transcribed into a hairpin structure and then processed with the Argonaute 2 (Ago 2) protein ( Wang, Wu & Yu, 2019 ). This miRNA is stable in peripheral blood and can be found in erythrocytes, PMN, mononuclear cells and platelets ( Ghai et al, 2019 ; Masaki et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Vitamin C supplementation reduces expression of circulating miR-451a in subjects with poorly controlled type 2 diabetes mellitus and high oxidative stress

Ruknarong

Boonthongkaew

Chuangchot

et al. 2021

PeerJ

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Background Vitamin C is an essential element required for normal metabolic function. We investigated the effect of vitamin C supplementation on circulating miRNA (miR) expression in subjects with poorly controlled type 2 diabetes mellitus (T2DM). Changes in miR expression were also correlated with clinical measures of disease. Methods Pre- and post-vitamin C supplementation samples from five participants who had increased vitamin C levels, improved oxidative status and polymorphonuclear (PMN) function after receiving 1,000 mg of vitamin C daily for six weeks were screened for miRNA expression using the NanoString miRNA assay. Differences in miRNA expression identified from the miRNA screen were validated by qRT-PCR. Results Four miRNAs showed significantly different expression post-vitamin C supplementation relative to baseline, including the down-regulation of miR-451a (−1.72 fold change (FC), p = 0.036) and up-regulation of miR-1253 (0.62 FC, p = 0.027), miR-1290 (0.53 FC, p = 0.036) and miR-644a (0.5 FC, p = 0.042). The validation study showed only miR-451a expression was significantly different from baseline with vitamin C supplementation. MiR-451a expression was negatively correlated with vitamin C levels (r = − 0.497, p = 0.049) but positively correlated with levels of malondialdehyde (MDA) (r = 0.584, p = 0.017), cholesterol (r = 0.564, p = 0.022) and low-density lipoproteins (LDL) (r = 0.522, p = 0.037). Bioinformatics analysis of the putative target genes of miR-451a indicated gene functions related to signaling pathways involved in cellular processes, such as the mammalian target of rapamycin (mTOR) signaling pathway. Conclusions Vitamin C supplementation altered circulating miR-451a expression. The results from this pilot study suggest that miRNAs could be used as biomarkers to indicate oxidative status in subjects with T2DM and with poor glycemic control and could lead to a novel molecular strategy to reduce oxidative stress in T2DM.

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“…In particular, animal studies showed that the deletion of the miR-144 locus in aged mice induces the development of B-cell lymphoma and acute myeloid leukemia. The underlying mechanism is that the downregulation of miR-144 leads to the overexpression of Myc (an oncogene) in DLBCL [20]. Conversely, Montes-Moreno et al reported the upregulation of miR-144 with miR-222, miR-451, and miR-221 in the ABC-type of DLBCL [21].…”

Section: Mir-144 In Diffuse B Cell Lymphomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.Int. J. Mol. Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers. More than 50% of miRNA genes were discovered to be located within the genomic regions that are involved in cancers, suggesting their role in human cancer pathogenesis. In pathological conditions, MiRNAs can negatively regulate gene expression and they are associated with tumor growth, apoptosis, invasion, and metastasis. In the past, several studies have indicated the ability of miRNAs in the inhibition of tumors as a critical option for the improvement of cancer therapy [4,5]. Tumor activator miRNAs, called oncomiRs, are overexpressed in various cancers. On the contrary, suppressive tumor miRNAs are underexpressed [6][7][8]. Among several miRNAs assessed, miR-144s seem to have a role in several cancers. These miRNAs are located in the chromosomal region 17q11.2, being significantly destroyed in many types of cancers. The predicted stem-loop structure of miR-144s recognized by the miRBase (http://mirbase.org/) is shown in Figure 1A. The miR-144 hairpin gives rise to the "guide strand" miR-144-5p and the sister "passenger" strand miR-144-3p ( Figure 1B).

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miR-144/451 in hematopoiesis and beyond

Cited by 24 publications

References 109 publications

Collective invasion of glioma cells through OCT1 signalling and interaction with reactive astrocytes after surgery

Collective invasion of glioma cells through OCT1 signalling and interaction with reactive astrocytes after surgery

Vitamin C supplementation reduces expression of circulating miR-451a in subjects with poorly controlled type 2 diabetes mellitus and high oxidative stress

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

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