miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism

Zhang, Tengfei; Zhang, Zhen; Li, Feng; Yü, Ping; Qin, Guohui; Zhang, Chaoqi; Zhang, Yi

doi:10.4049/jimmunol.1800230

Cited by 72 publications

(62 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, stability in water was better for all samples, and it lasted for a longer period of time in some cases. Zhang et al reported similar stability results in several polar solvents [74]. By treating oxidized graphene with IL 1-allyl-3-methylimidazolium chloride, they produced a water-soluble graphene.…”

Section: Dispersibility and Suspension Stabilitymentioning

confidence: 53%

Functionalization of graphene using deep eutectic solvents

Hayyan¹,

Abo-Hamad²,

AlSaadi³

et al. 2016

Nano Online

View full text Add to dashboard Cite

(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Deep eutectic solvents (DESs) have received attention in various applications because of their distinctive properties. In this work, DESs were used as functionalizing agents for graphene due to their potential to introduce new functional groups and cause other surface modifications. Eighteen different types of ammonium-and phosphonium-salt-based DESs were prepared and characterized by FTIR. The graphene was characterized by FTIR, STA, Raman spectroscopy, XRD, SEM, and TEM.Additional experiments were performed to study the dispersion behavior of the functionalized graphene in different solvents. The DESs exhibited both reduction and functionalization effects on DES-treated graphene. Dispersion stability was investigated and then characterized by UV-vis spectroscopy and zeta potential. DES-modified graphene can be used in many applications, such as drug delivery, wastewater treatment, catalysts, composite materials, nanofluids, and biosensors. To the best of our knowledge, this is the first investigation on the use of DESs for graphene functionalization.

show abstract

Section: Dispersibility and Suspension Stabilitymentioning

confidence: 53%

Functionalization of graphene using deep eutectic solvents

Hayyan¹,

Abo-Hamad²,

AlSaadi³

et al. 2016

Nano Online

View full text Add to dashboard Cite

show abstract

“…The main pathway of activation was through src homology 2 (SH2) ‐ containing inositol 5‐phosphatase (SHIP) inhibition which increased STAT5a activation, T cell persistence, and enhanced T cell activation via Akt. Similarly, overexpression of miR‐143 enhanced central memory T cell development, decreased apoptosis and potentiated proinflammatory cytokine secretion and anti‐tumor cytotoxicity of HER2‐CAR T cells …”

Section: Strategies To Enhance Car T Cell Persistence and Memorymentioning

confidence: 98%

“…Similarly, overexpression of miR-143 enhanced central memory T cell development, decreased apoptosis and potentiated proinflammatory cytokine secretion and anti-tumor cytotoxicity of HER2-CAR T cells. 62…”

Section: Micro Rnamentioning

confidence: 99%

Chimeric antigen receptor T cell persistence and memory cell formation

2019

View full text Add to dashboard Cite

It is now becoming clear that less differentiated naive and memory T cells are superior to effector T cells in the transfer of immunity for adoptive cell therapy. This review will outline the challenges faced by chimeric antigen receptor (CAR) T cell therapy in the generation of persistence and memory for CAR T cells, and summarize recent strategies to improve CAR T cell persistence, with a focus on memory cell formation. The relevance of enhancing persistence in more differentiated effector T cells is also covered, because genetic and pharmacological interventions may prolong effector T cell activity and lifespan, thereby improving anti‐cancer activity. In particular, it may be possible to enforce epigenetic changes in differentiated T cells to enhance memory CAR T cell formation. Optimizing the generation of self‐renewing T cell populations (e.g. memory cells), while maintaining differentiated effector T cells through epigenome modification, will help overcome barriers to T cell expansion and survival, thereby improving clinical outcomes in CAR T cell therapy.

show abstract

“…In addition, Zhang et al found that miR-143 promoted the differentiation of central memory T cells and increased the secretion of cytokines. Further investigation indicated that miR-143 overexpression boosted the specific killing activity of HER2-CAR T cells against TE-7 cells by inhibiting glucose uptake and glycolysis [151].…”

Section: The Effect Of Mirnas On Immunotherapymentioning

confidence: 99%

The role of cancer-derived microRNAs in cancer immune escape

et al. 2020

View full text Add to dashboard Cite

During malignant transformation, accumulated somatic mutations endow cancer cells with increased invasiveness and immunogenicity. Under selective pressure, these highly immunogenic cancer cells develop multiple strategies to evade immune attack. It has been well established that cancer cells could downregulate the expression of major histocompatibility complex, acquire alterations in interferon pathway, and upregulate the activities of immune checkpoint pathways. Besides, cancer cells secret numerous cytokines, exosomes, and microvesicles to regulate the functions and abundances of components in the tumor microenvironment including immune effector cells and professional antigen presentation cells. As the vital determinant of post-transcriptional regulation, microRNAs (miRNAs) not only participate in cancer initiation and progression but also regulate anti-cancer immune response. For instance, some miRNAs affect cancer immune surveillance and immune escape by interfering the expression of immune attack-associated molecules. A growing body of evidence indicated that cancer-derived immune modulatory miRNAs might be promising targets to counteract cancer immune escape. In this review, we summarized the role of some miRNAs in cancer immune escape and discussed their potential clinical application as treatment targets.

show abstract

miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism

Cited by 72 publications

References 43 publications

Functionalization of graphene using deep eutectic solvents

Functionalization of graphene using deep eutectic solvents

Chimeric antigen receptor T cell persistence and memory cell formation

The role of cancer-derived microRNAs in cancer immune escape

Contact Info

Product

Resources

About