miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS

Xu, Bin; Niu, Xiaobing; Zhang, Xiangxiang; Tao, Jun; Wu, Donghai; Wang, Zidun; Li, Pengchao; Zhang, Wei; Wu, Hongfei; Feng, Na; Wang, Zengjun; Liu, Hua; Wang, Xinru

doi:10.1007/s11010-010-0700-6

Cited by 189 publications

(152 citation statements)

References 19 publications

Supporting

Mentioning

141

Contrasting

Unclassified

Order By: Relevance

“…Xu et al reported that miR-143 regulates KRAS, p-ERK1/2 and cyclin D1, and plays a role in cell proliferation, migration and chemosensitivity in prostate cancer cells (19). In addition, miR-143 is important for bone metastasis in prostate cancer and may be clinically useful as a novel biomarker for the determination of various stages of human prostate cancer, predicting metastasis or even as therapeutic targets in bone metastasis of prostate cancer (20).…”

Section: Mmp-13 Is a Direct Target Gene Of Mir-143 In Prostate Cancermentioning

confidence: 99%

MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer

Huang

Wang

et al. 2013

Molecular Medicine Reports

Self Cite

View full text Add to dashboard Cite

Abstract. has been previously reported to be downregulated in specific types of cancer, including colorectal, bladder, oral squamous cell, pituitary, cervical, nasopharyngeal, lymphoma and prostate cancer. In the present study, the effects of miR-143 on prostate cancer cell migration and invasion were examined. Following transfection with miR-143, miR-143 expression, cell migration and invasion assays, luciferase assay and western blot analysis were conducted in prostate cancer cell lines. The results indicated that miR-143 inhibits cell migration and invasion in DU145 and PC-3 cells. In addition, to the best of our knowledge, miR-143 was reported for the first time to directly target matrix metalloproteinase 13 (MMP-13) in prostate cancer. The results of the present study demonstrated that miR-143 suppresses cell migration and invasion by targeting MMP-13 in prostate cancer cell lines. These results indicated that miR-143 may be suitable for the development of novel molecular markers and therapeutic approaches to inhibit metastasis in prostate cancer.

show abstract

Section: Mmp-13 Is a Direct Target Gene Of Mir-143 In Prostate Cancermentioning

confidence: 99%

MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer

Huang

Wang

et al. 2013

Molecular Medicine Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…Previously, it has been demonstrated that the miR clusters miR-143 and miR-145 at the chromosome 5q32 region are downregulated in various human tumors and are able to suppress tumor growth in cancer of the urogenital (4,5), digestive (6) and respiratory systems (3), as well as in osteosarcoma (7), breast cancer (8) and leukemia (9). Furthermore, numerous types of human cancer cell exhibit a markedly reduced expression of miR-143 and miR-145 compared to normal tissues (10).…”

Section: Introductionmentioning

confidence: 99%

miR-143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells

et al. 2016

View full text Add to dashboard Cite

Abstract. Inappropriate expression of microRNA (miR) is strongly associated with carcinogenesis. miR-143 was reported to be one of the most prominent miRs implicated in the genesis and progression of human cancer. However, its correlation with cell proliferation and apoptosis in cervical cancer remains to be fully elucidated. In the present study, it was demonstrated that miR-143 is able to suppress the proliferation of cervical cancer HeLa cells and induce cell apoptosis in a time-and dose-dependent manner. The present study also investigated the potential targets of miR-143, extracellular-signal-regulated kinase 5 (ERK5) and its downstream substrate oncoprotein c-Fos, both of which are involved in cell proliferation and apoptosis. Upon increasing the miR-143 level, the ERK5 and c-Fos protein expression was significantly decreased without the effect of ERK5 transcription. Therefore, miR-143 is able to suppress cell proliferation and induce apoptosis in HeLa cells, potentially through negative regulation of ERK5 at its post-transcriptional stage.

show abstract

“…These signaling pathways are involved in cell differentiation, proliferation, survival rate, migration, invasion, cytoskeletal changes and the cell cycle (34,35). KRAS is a member of the epidermal growth factor receptor (EGFR)/RAS/mitogen activated protein kinases (MAPK) cell signaling pathway and has previously been demonstrated to be associated with physiological and pathological processes (36).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-134 targets KRAS to suppress breast cancer cell proliferation, migration and invasion

Zhang

et al. 2017

Oncology Letters

View full text Add to dashboard Cite

Abstract. The expression patterns and functions of microRNA-134 (miR-134) have been previously studied in numerous types of cancer. To the best of our knowledge, this is the first study of miR-134 in human breast cancer. In the present study, the expression patterns, biological functions and underlying molecular mechanisms of miR-134 in human breast cancer were investigated. Reverse transcription-quantitative polymerase chain reaction evaluated the expression of miR-134 in human breast cancer tissues, matched normal adjacent tissues, breast cancer cell lines and a normal mammary epithelial cell line. Following transfection with miR-134, an MTT assay, cell migration assay, cell invasion assay, western blot analysis and a luciferase assay were performed on the MCF-7 and MDA-MB-231 human breast cancer cell lines. The findings revealed that miR-134 expression levels were significantly downregulated in breast cancer cells. Statistical analysis demonstrated that low expression of miR-134 was significantly associated with lymph node metastasis, TNM stage and reduced cell differentiation. It was observed that miR-134 inhibited the growth, migration and invasion of breast cancer cells. Additionally, the present study indicated that miR-134 may directly target the Kirsten rat sarcoma viral oncogene homolog in breast cancer tissues. These results suggest that miR-134 may be used as a potential therapeutic biomarker in breast cancers.

show abstract

miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS

Cited by 189 publications

References 19 publications

MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer

MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer

miR-143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells

MicroRNA-134 targets KRAS to suppress breast cancer cell proliferation, migration and invasion

Contact Info

Product

Resources

About