2011
DOI: 10.1007/s11010-010-0700-6
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Abstract: MicroRNAs have been implicated in regulating diverse cellular pathways. Emerging evidence indicates that miR-143 plays causal roles in cancer tumorigenesis as a tumor suppress gene; however, its role in prostate cancer tumorigenesis remains largely unknown. The aims of this study were to verify the effect of miR-143 on proliferation and migration abilities of prostate cancer cells. The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting, respectively. Effects… Show more

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Cited by 187 publications
(148 citation statements)
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“…Xu et al reported that miR-143 regulates KRAS, p-ERK1/2 and cyclin D1, and plays a role in cell proliferation, migration and chemosensitivity in prostate cancer cells (19). In addition, miR-143 is important for bone metastasis in prostate cancer and may be clinically useful as a novel biomarker for the determination of various stages of human prostate cancer, predicting metastasis or even as therapeutic targets in bone metastasis of prostate cancer (20).…”
Section: Mmp-13 Is a Direct Target Gene Of Mir-143 In Prostate Cancermentioning
confidence: 99%
“…Xu et al reported that miR-143 regulates KRAS, p-ERK1/2 and cyclin D1, and plays a role in cell proliferation, migration and chemosensitivity in prostate cancer cells (19). In addition, miR-143 is important for bone metastasis in prostate cancer and may be clinically useful as a novel biomarker for the determination of various stages of human prostate cancer, predicting metastasis or even as therapeutic targets in bone metastasis of prostate cancer (20).…”
Section: Mmp-13 Is a Direct Target Gene Of Mir-143 In Prostate Cancermentioning
confidence: 99%
“…These signaling pathways are involved in cell differentiation, proliferation, survival rate, migration, invasion, cytoskeletal changes and the cell cycle (34,35). KRAS is a member of the epidermal growth factor receptor (EGFR)/RAS/mitogen activated protein kinases (MAPK) cell signaling pathway and has previously been demonstrated to be associated with physiological and pathological processes (36).…”
Section: Discussionmentioning
confidence: 99%
“…MiR-143 is also involved in the suppression of bladder cancer and osteosarcoma by targeting cyclooxygenase-2 and matrix metalloprotease-13 (15,25), and the progression of colorectal cancer is reported to be significantly correlated with lower miR-143 expression (11). Xu et al overexpressed miR-143 in prostate cancer cells and observed that miR-143 transfection could effectively increase the sensitivity to docetaxel treatment, probably through RAS/MAPK signaling (26). Administration of miR-143 to nude mice harboring DLD-1 tumors also indicated that tumor volumes are decreased accordingly with injection doses (27).…”
Section: Discussionmentioning
confidence: 99%