MiR‐142‐3p as a potential prognostic biomarker for esophageal squamous cell carcinoma

Lin, Ruijun; Di, Xiao; Liao, Lian‐Di; Chen, Tao; Xie, Zefeng; Huang, Weiguo; Wang, Wei-Sen; Jiang, Tai-Feng; Wu, Bing‐Li; Li, En‐Min; Xu, Li‐Yan

doi:10.1002/jso.22066

Cited by 109 publications

(77 citation statements)

References 44 publications

(43 reference statements)

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“…Recent studies have found that miRNA has the effects of both oncogenes and anti-oncogenes and plays an important role in the initiation and development of tumors (Zhou et al, 2009;He et al, 2012). Numerous miRNAs directly participate in the initiation and development of tumors, and miRNA spectra are correlated with the diagnosis, staging, progression, and prognosis of EC (Lin et al, 2012;Xu et al, 2012;Yang et al, 2013). Studies using microarray technology on the miRNA expression spectra of 31 EC tissue samples have discovered that 46 miRNAs exhibit abnormal expression, 7 of which exhibit significant differences, compared with those in normal tissues; furthermore, the high expression of has-miR-103/107 is closely correlated with low survival rate.…”

Section: Screening Of Microrna In Patients With Esophageal Cancer At mentioning

confidence: 99%

Screening of MicroRNA in Patients with Esophageal Cancer at Same Tumor Node Metastasis Stage with Different Prognoses

Zhao

Liu²,

Tianyun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Patients at the same pathological stage of esophageal cancer (EC) that received the same surgical therapy by the same surgeon may have distinct prognoses. The current study aimed to explore the possibility of differentiallyexpressed microRNAs (miRNAs) underlying this phenomenon. Samples were collected from EC patients at the same tumor node metastasis (TNM) stage but with different prognoses. Paracancerous normal tissues were taken as controls. The specimens were histopathologically analyzed. Differentially-expressed miRNAs were analyzed using real-time quantitative reverse transcription polymerase chain reaction. Compared with patients with poor prognosis, those with good prognosis exhibited 88 two-fold or more than two-fold increased miRNA fragments and 4 half-decreased miRNAs. The most noticeably up-regulated miRNAs included hsa-miR-31, hsa-miR196b, hsa-miR-652, hsa-miR-125a-5p, hsa-miR-146b, hsa-miR-200c, hsa-miR-23b, hsa-miR-29a, hsa-miR-186, hsa-miR-205, hsa-miR-376a, hsa-miR-410, hsa-miR-532-3p, and hsa-miR-598, whereas the most significantlydownregulated miRNAs were hsa-let-7e, hsa-miR-130b, and hsa-miR-103. EC patients at same TNM stage but with different prognoses show differentially-expressed miRNAs.

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Section: Screening Of Microrna In Patients With Esophageal Cancer At mentioning

confidence: 99%

Screening of MicroRNA in Patients with Esophageal Cancer at Same Tumor Node Metastasis Stage with Different Prognoses

Zhao

Liu²,

Tianyun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…It was suggested that miR-142 may play an important role in maintaining the selfrenewal capacity of bronchioalveolar stem cells (7). It was also found that esophageal squamous cell carcinoma patients with high expression of miR-142 had poorer survival rates than those with low expression of miR-142, suggesting that miR-142 may act as a tumor suppressor (8). miR-142 was found to be downregulated in osteosarcoma cell lines (9), however, the role of miR-142 in osteosarcoma remains unknown.…”

Section: Introductionmentioning

confidence: 99%

miR-142 acts as a tumor suppressor in osteosarcoma cell lines by targeting Rac1

Zheng

Ding

et al. 2014

Oncology Reports

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Abstract. Although the 5-year survival rate of osteosarcoma (OS) has risen to ~60-70%, a substantial portion of patients still respond poorly to chemotherapy and have a high risk of relapse or metastasis even after curative resection. In this study, we found that the expression of miR-142 was significantly reduced in OS tissues and OS cell lines, while Ras-related C3 botulinum toxin substrate 1 (Rac1) expression was increased in the OS tissues and OS cell lines compared with expression in the controls. We then demonstrated that miR-142 regulated Rac1 expression at the transcriptional and translational levels by directly targeting its 3'-untranslated region (3'UTR). In addition, by loss-and gain-of function experiments, we investigated the role of miR-142 in OS cell lines and found that miR-142 acted as a tumor suppressor in the OS cell lines and inhibited cell proliferation and cell invasion and arrested cell cycle in the S phase. Furthermore, miR-142 inhibited osteosarcoma cell invasion by inducing E-cadherin expression and reducing expression of matrix metalloproteinase 2 (MMP2) and MMP9. Thus, overexpression of miR-142 and/or knockdown of Rac1 would be a novel target for OS therapy in the future.

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“…It was suggested that miR-142 may play an important role in maintaining the self-renewal capacity of bronchioalveolar stem cells (15). It was also reported that patients with esophageal squamous cell carcinoma (ESCC) displaying a high expression of miR-142 had poorer survival rates compared with those with low expression of miR-142, suggesting that miR-142 may act as a tumor suppressor (16).…”

Section: Introductionmentioning

confidence: 99%

Demethylation of microRNA-142 induced by demethylation agents plays a suppressive role in osteosarcoma cells

Ding¹,

Hu²,

Ni³

et al. 2015

Oncology Letters

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Abstract. Osteosarcoma (OS), the most common malignant bone tumor, occurs mainly in adolescents and young adults, with a morbidity of ~5 cases per million. The expression levels of microRNAs (miRNAs) as tumor suppressors were recently found to be downregulated in OS. Certain alterations of miRNAs and the possible mechanisms through which miRNAs affect cell proliferation and migration in OS were recently found to be correlated with methylation epigenetic mechanisms. In this study, it was demonstrated that, due to hypermethylation, the expression level of miRNA-142 (miR-142) was significantly downregulated in OS tissues and cells compared with that in control samples. The present study demonstrated an increased expression of miR-142 in Saos-2 and MG63 cells treated with demethylation agents, suggesting that the effect of such agents on cell growth, inhibition of invasion and cell cycle retardation may be mediated by miR-142 in OS.

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MiR‐142‐3p as a potential prognostic biomarker for esophageal squamous cell carcinoma

Abstract: The main findings suggest that miR-142-3p is involved in the progression of ESCC and is a potential prognostic biomarker for ESCC.

Cited by 109 publications

References 44 publications

Screening of MicroRNA in Patients with Esophageal Cancer at Same Tumor Node Metastasis Stage with Different Prognoses

Screening of MicroRNA in Patients with Esophageal Cancer at Same Tumor Node Metastasis Stage with Different Prognoses

miR-142 acts as a tumor suppressor in osteosarcoma cell lines by targeting Rac1

Demethylation of microRNA-142 induced by demethylation agents plays a suppressive role in osteosarcoma cells

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