miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3

Abstract

MicroRNAs (miRNAs) function as essential post-transcriptional modulators of gene expression involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs have been deregulated in hepatocellular carcinoma (HCC). Here, we investigated the role of miR-141 in HCC. Decreased expression of miR-141 was observed in both HCC tissues and cell lines. Ectopic overexpression of miR-141 reduced proliferation, migration, and invasion of HCC cells. E2F transcription factor 3 (E2F3) was confirmed to be a target of miR-141 in HCC cells. Moreover, restoration of E2F3 significantly reversed the tumor suppressive effects of miR-141. Our results suggest a critical role of miR-141 in suppressing metastasis of HCC cells by targeting E2F3.

Long Noncoding RNA CRNDE Promotes Proliferation of Gastric Cancer Cells by Targeting miR-145

“…A number of studies have reported that E2F3 is targeted by various miRNAs and is involved in the genesis and progression of human cancers [31-34]. Our study showed that E2F3 expression was significantly increased by upregulating CRNDE expression, whereas shCRNDE significantly decreased E2F3 expression.…”

MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2

“…MicroRNAs (miRNAs) are small molecules ranging in size from 17 to 22 bases [19][20][21]. miRNA-mediated control is one of the posttranscriptional mechanisms that suppress protein translation by matching to the 3′-untranslated region (UTR, 3′-UTR) of the target gene [22,23].…”

miR‑144 suppresses proliferation and induces apoptosis of osteosarcoma cells via direct regulation of mTOR expression

“…It is generally considered that miR-144 is able to function as a suppressor gene of tumor proliferation and affect the prognosis of patients with osteosarcoma (36,37). Studies have reported that subsequent to transfecting liver cancer HepG2 cells, the plasmids of overexpressed miR-144 are able to promote apoptosis and inhibit the occurrence of liver cancer metastasis by affecting the expression of E2F3 (34,38).…”