MiR-141-3p functions as a tumor suppressor through directly targeting ZFR in non-small cell lung cancer

Weisong, Li; Cui, Yongmei; Wang, Dan; Wang, Yuefeng; Wang, Liantang

doi:10.1016/j.bbrc.2018.12.089

Cited by 48 publications

(41 citation statements)

References 26 publications

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“…Additionally, miR-142-3p targets HMGB1 to inhibit hypoxia/reoxygenation-induced cardiomyocyte apoptosis and fibrosis (61). miR-142-3p is also reported to inhibit tumor growth of lung cancer through targeting HMGB1 (62). The present results are consistent with these findings by identifying HMGB1 as a functional target gene of miR-142-3p.…”

Section: Discussionsupporting

confidence: 90%

MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1

et al. 2017

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MicroRNA (miRNA) are emerging as critical regulators of neuropathic pain development. Neuroinflammation contributes to the development of neuropathic pain. miR‑142‑3p has been characterized as an inflammation‑related miRNA in various pathological processes. However, little is known about the role of miR‑142‑3p in neuroinflammation and neuropathic pain. The present study aimed to investigate the function of miR‑142‑3p in neuropathic pain by creating a murine model using spinal nerve ligation (SNL). A significant reduction in miR‑142‑3p expression was observed in the dorsal root ganglion of mice with SNL (P<0.05) compared with control mice. Overexpression of miR‑142‑3p significantly inhibited neuropathic pain and neuroinflammation in mice with SNL (P<0.05). High mobility group box 1 (HMGB1) was identified as a direct target gene of miR‑142‑3p by bioinformatic analysis and dual‑luciferase reporter assays. Overexpression of miR‑142‑3p significantly reduced the mRNA and protein expression levels of HMGB1 in vitro and in vivo (P<0.05). In addition, HMGB1 mRNA expression and miR‑142‑3p expression were inversely correlated in mice with SNL. Furthermore, overexpression of HMGB1 significantly reversed the inhibitory effect of miR‑142‑3p on neuroinflammation and neuropathic pain development (P<0.05). Overall, these results suggest that miR‑142‑3p functions as a negative regulator of neuropathic pain development through the downregulation of HMGB1, indicating that miR‑142‑3p may serve as a potential therapeutic target for neuropathic pain.

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Section: Discussionsupporting

confidence: 90%

MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1

et al. 2017

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“…https://doi.org/10.1371/journal.pone.0229118.g002 metastasis in prostate cancer [24]. In NSCLC, Li et al found that miR-141-3p was markedly decreased in NSCLC tissues compared with adjacent normal tissues and low expression of miR-141-3p predicted poor overall survival [25]. Consistently, our findings demonstrated that miR-141-3p was inversely associated with lncRNA-ATB expression.…”

Section: Discussionsupporting

confidence: 87%

Long non-coding RNA ATB promotes human non-small cell lung cancer proliferation and metastasis by suppressing miR-141-3p

Zhang

2020

PLoS ONE

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Long noncoding RNA activated by transforming growth factor-β (lncRNA-ATB) plays a critical role in progression of several cancers. In this study, lncRNA-ATB was significantly upregulated in NSCLC tissues and cell lines, and high lncRNA-ATB expression indicated poor prognosis. Knockdown of lncRNA-ATB suppressed NSCLC cell growth, colony formation, migration, invasion and reversed epithelial-mesenchymal transition. In vivo study showed that silencing lncRNA-ATB inhibited tumor growth. Further mechanism studies demonstrated that lncRNA-ATB was a target of miR-141-3p. MiR-141-3p expression was negatively related to lncRNA-ATB expression in NSCLC tissues. These results suggested that inhibiting lncRNA-ATB might be an approach for NSCLC treatment.

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“…Moreover, the upstream promoter of miR-486-5p was shown to be strongly regulated by methylation in NSCLC (37). Xiao et al (38) investigated miR-142-3p in NSCLC, and their results suggested that miR-142-3p may be a tumor suppressor through downregulating HMGB1 in NSCLC. In addition, miR-378a-3p, miR-451a, miR-30c-2-3p, miR-210-3p and miR-708-5p were also reported to be dysregulated in lung cancer and might be related to initiation and development of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression

Sui

Yang

et al. 2017

Oncology Reports

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Lung adenocarcinoma (LUAD) is a complex disease that poses challenges for diagnosis and treatment. The aim of the present study is to investigate LUAD-specific key microRNAs (miRNAs) from large-scale samples in The Cancer Genome Atlas (TCGA) database. We used an integrative computational method to identify LUAD-specific key miRNAs related to TNM stage and lymphatic metastasis from the TCGA database. Twenty-five LUAD-specific key miRNAs (fold change >2, p<0.05) from the TCGA database were investigated, and 15 were found to be aberrantly expressed with respect to clinical features. Three miRNAs were correlated with overall survival (log-rank p<0.05). Then, 5 miRNAs were randomly selected for verification of expression in 53 LUAD patient tissues using qRT-PCR. Diagnostic value of these above 5 miRNAs was determined by areas under receiver operating characteristic curves (ROC). Finally, the LUAD-related miRNA miR-30a-3p was selected for verification of biologic function in A549 cells. The results of tests for cell proliferation, apoptosis, and target genes suggested that miR-30a-3p decreases cell proliferation and promotes apoptosis through targeting AKT3. Therefore, miR-30a-3p may be a promising biomarker for the early screening of high-risk populations and early diagnosis of LUAD. Our studies provide insights into identifying novel potential biomarkers for diagnosis and prognosis of LUAD.

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MiR-141-3p functions as a tumor suppressor through directly targeting ZFR in non-small cell lung cancer

Cited by 48 publications

References 26 publications

MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1

MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1

Long non-coding RNA ATB promotes human non-small cell lung cancer proliferation and metastasis by suppressing miR-141-3p

Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression

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