miR-139 and miR-200c regulate pancreatic cancer endothelial cell migration and angiogenesis

Li, Lei; Li, Baiwen; Chen, Dafan; Liu, Liyan; Huang, Chen; Lu, Zhanjun; Lun, Lungen; Wan, Xinjian

doi:10.3892/or.2015.3945

Cited by 43 publications

(33 citation statements)

References 46 publications

(48 reference statements)

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“…2), and their frequent loss with concomitant increase in ZEB1 and ZEB2 expression has been observed in different cancers promoting EMT by downregulating Ecadherin [16,32,33]. Conversely, ectopic expression of E-cadherin in mesenchymal cells promotes the reverse process and mesenchymal-epithelial transition, confirming bona fide effects [31,34].…”

Section: Role Of Mir-200c In Epithelial-mesenchymal Transitionmentioning

confidence: 80%

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

et al. 2016

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MicroRNAs (miRNAs) are 20-22-nucleotide small endogenous non-coding RNAs which regulate gene expression at post-transcriptional level. In the last two decades, identification of almost 2600 miRNAs in human and their potential to be modulated opened a new avenue to target almost all hallmarks of cancer. miRNAs have been classified as tumor suppressors or oncogenes depending on the phenotype they induce, the targets they modulate, and the tissue where they function. miR-200c, an illustrious tumor suppressor, is one of the highly studied miRNAs in terms of development, stemness, proliferation, epithelial-mesenchymal transition (EMT), therapy resistance, and metastasis. In this review, we first focus on the regulation of miR-200c expression and its role in regulating EMT in a ZEB1/E-cadherin axis-dependent and ZEB1/E-cadherin axis-independent manner. We then describe the role of miR-200c in therapy resistance in terms of multidrug resistance, chemoresistance, targeted therapy resistance, and radiotherapy resistance in various cancer types. We highlight the importance of miR-200c at the intersection of EMT and chemoresistance. Furthermore, we show how miR-200c coordinates several important signaling cascades such as TGF-β signaling, PI3K/Akt signaling, Notch signaling, VEGF signaling, and NF-κB signaling. Finally, we discuss miR-200c as a potential prognostic/diagnostic biomarker in several diseases, but mainly focusing on cancer and its potential application in future therapeutics.

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Section: Role Of Mir-200c In Epithelial-mesenchymal Transitionmentioning

confidence: 80%

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

et al. 2016

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“…Seven of these, mir-139, mir-140, mir-26a, mir-424, mir-503, mir-505, and mir-542 have been shown to be involved in angiogenesis [55–63]. Although mir-139 has been reported to act as a tumor suppressor in most studies, its role in angiogenesis is becoming clearer [55, 56, 64, 65]. Mir-139 was found to increase cancer endothelial cell migration and promote vessel formation in pancreatic cancer [55].…”

Section: Discussionmentioning

confidence: 99%

“…Although mir-139 has been reported to act as a tumor suppressor in most studies, its role in angiogenesis is becoming clearer [55, 56, 64, 65]. Mir-139 was found to increase cancer endothelial cell migration and promote vessel formation in pancreatic cancer [55]. Mir-139 was also found to negatively regulate CXCR4, playing a role in tightly regulating angiogenesis to prevent over-activation of endothelial cells [56].…”

Section: Discussionmentioning

confidence: 99%

A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs

et al. 2016

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BackgroundSplenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulation, and differential expression of miRNAs between normal and tumor tissue has been used to diagnose neoplastic diseases. The objective of this study was to determine differential expression of miRNAs by use of RNA-sequencing in canine spleens that were histologically confirmed as hemangiosarcoma, nodular hyperplasia, or normal.ResultsTwenty-two miRNAs were found to be differentially expressed in hemangiosarcoma samples (4 between hemangiosarcoma and both nodular hyperplasia and normal spleen and 18 between hemangiosarcoma and normal spleen only). In particular, mir-26a, mir-126, mir-139, mir-140, mir-150, mir-203, mir-424, mir-503, mir-505, mir-542, mir-30e, mir-33b, mir-365, mir-758, mir-22, and mir-452 are of interest in the pathogenesis of hemangiosarcoma.ConclusionsFindings of this study confirm the hypothesis that miRNA expression profiles are different between canine splenic hemangiosarcoma, nodular hyperplasia, and normal spleens. A large portion of the differentially expressed miRNAs have roles in angiogenesis, with an additional group of miRNAs being dysregulated in vascular disease processes. Two other miRNAs have been implicated in cancer pathways such as PTEN and cell cycle checkpoints. The finding of multiple miRNAs with roles in angiogenesis and vascular disease is important, as hemangiosarcoma is a tumor of endothelial cells, which are driven by angiogenic stimuli. This study shows that miRNA dysregulation is a potential player in the pathogenesis of canine splenic hemangiosarcoma.

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“…This angiogenesis decreasing effect shows the similarity with an earlier report . In addition, the regulatory role of miR-200c in angiogenesis in the pancreatic tumors has been reported by Li et al (2015).…”

Section: Discussionmentioning

confidence: 95%