MiR-139-3p induces cell apoptosis and inhibits metastasis of cervical cancer by targeting NOB1

Huang, Ping; Xi, Jie; Liu, Shikai

doi:10.1016/j.biopha.2016.07.050

Cited by 63 publications

(45 citation statements)

References 22 publications

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“…miR-139 was lowly expressed in these cancers, while highly expressed in normal tissues or cells. miR-139 was found to induce cell apoptosis, suppress the tumor growth and decrease tumor metastasis and drug sensitivity by inhibiting the EMT signaling pathway (30,32). Overexpression of miR-139-5p resulted in the inhibition of uterine leiomyoma cell growth (34).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139

et al. 2017

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Abstract. Hepatocellular carcinoma (HCC) is a highly malignant tumor and one of the most common causes for human cancer-related deaths. Fibroblast growth factor 18 (FGF18) is overexpressed in many types of cancer, and is associated with cell proliferation, invasion and angiogenesis. miR-139 has recently been reported as a tumor suppressor in various types of cancer and it can regulate many tumor-related genes, however its association with FGF18 expression in HCC has not been reported and thus remains unknown. In the present study, to explore the potential regulation mechanism of miR-139 with FGF18 in HCC, HCC tissues and cell lines were used. The results revealed that FGF18 was highly expressed in HCC tissues and cells, however miR-139 was lowly expressed. FGF18 was demonstrated to be a direct target of miR-139. Furthermore, the suppressive effect of miR-139 on FGF18 and in turn on proliferation, apoptosis, invasion, migration and tumor-induced angiogenesis of HCC cells was investigated. FGF18 was suggested as a prognostic biomarker and therapeutic target in HCC patients and miR-139 may be a promising strategy used in HCC treatment via the suppression of FGF18.

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Section: Discussionmentioning

confidence: 99%

Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139

et al. 2017

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“…Seventeen miRNAs, including 4 up-regulations and 13 down-regulations (Table 4), were dysregulated in the serum of patients with colon cancer when compared to the serum of patients with colon adenomas. These DEMs were functionally related with cancer cell migration and invasion (miR-10a [19, 20], miR-124-3p [21, 22], let-7f [23], miR-140-5p [24], miR-139-3p [25] and miR-302c-3p [26]), growth (miR-124-3p [22], miR-124-5p [27] miR-140-5p [24] and miR-302c-3p [26]), cell cycle regulation (miR-107 [28]), cell apoptosis (miR-139-3p [25]), chemoresistance (miR-140-5p [29] and miR-487a [30]), and DNA repair (miR-638 [31]), and thus may be more critical to the development of colon cancer.…”

Section: Resultsmentioning

confidence: 99%

Serum MicroRNA profile in patients with colon adenomas or cancer

Zhang

Ding

et al. 2017

BMC Med Genomics

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BackgroundColon cancer, one of the most common causes of cancer-related deaths, arises from adenomatous polyps. In these years, circulating microRNAs (miRNAs) have attracted increasing attention as novel biomarkers for colon cancers. The dysregulated circulating miRNAs in patients with colon adenomas has not been well-understood.MethodsHere, we aimed to identify miRNA profile in the serum of patients with colon adenomas or colon cancer by using microarray. Then we validated eight differentially expressed miRNAs (DEMs) by qRT-PCR and predicted their targets.ResultsWe identified 26 DEMs from Adenomas versus Normal comparison (11 up-regulations and 15 down-regulations), 72 DEMs from Cancer versus Normal comparison (19 up-regulations and 53 down-regulations) and 17 DEMs from Cancer versus Adenomas comparison (4 up-regulations and 13 down-regulations). Moreover, three DEMs identified from Cancer versus Normal comparison were included in the list of DEMs identified from Cancer versus Adenomas comparison, and may be specific diagnostic biomarkers for colon cancer. Five down-regulated miRNAs identified from Cancer versus Normal comparison were included in the list of DEMs identified from Adenomas versus Normal comparison, and may be important for the development of colon polyps and cancer.ConclusionsWe discovered 8 circulating miRNAs associated with colon adenomas and colon cancer, and these miRNAs may potentially serve as noninvasive screening biomarkers for colon cancer. Our study is useful for expanding our understanding in the development of colon adenomas and colon cancer, and thus provide novel insights into colon cancer pathogenesis and prevention.Electronic supplementary materialThe online version of this article (doi:10.1186/s12920-017-0260-7) contains supplementary material, which is available to authorized users.

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“…NOB1 was reportedly linked to the onset and development of various tumours and plays the role of an oncogene . A previous study showed that NOB1 levels were elevated in cervical cancer tissues and cell lines . Studies have also demonstrated that miR‐139‐3p inhibited cervical cancer cell proliferation, migration, and invasion and induced cell apoptosis through down‐regulation of NOB1 expression.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐612 inhibits cervical cancer progression by targeting NOB1

Yang

Zhou

Yao

et al. 2020

J Cellular Molecular Medi

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Recently, many studies have shown that microRNA (miR)‐612 is involved in cancer progression. However, the role of miR‐612 in cervical cancer remains unclear. The present study aims to investigate the biological effects of miR‐612 on cervical cancer. The expression of miR‐612 in cervical cancer tissues and cell lines was analysed by quantitative reverse transcription‐polymerase chain reaction. The effect of miR‐612 cell proliferation, migration, invasion and apoptosis was studied by appropriate methods. Protein expression was determined by Western blot analyses. Bioinformatics analysis and luciferase reporter assays were performed to clarify the relationship between miR‐612 and nin one binding protein (NOB1). A xenograft model was established to examine the role of miR‐612 in vivo tumorigenesis. Cervical cancer tissues and cell lines showed down‐regulation of miR‐612 expression, which was associated with the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage and lymph node metastasis. Functional assays revealed that miR‐612 overexpression significantly suppressed cervical cancer cell proliferation, migration and invasion in vitro and delayed tumour growth in vivo. Mechanically, miR‐612 targeted NOB1 in cervical cancer cells, revealing a negative correlation between miR‐612 and NOB1in cervical cancer samples. NOB1 overexpression partially reversed the inhibitory effects of miR‐612 overexpression in cervical cancer cells. Taken together, these findings indicate that miR‐612 functions as a tumour suppressor in cervical cancer and suggest that miR‐612 may be a potential target in the therapeutic intervention of this malignancy.

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MiR-139-3p induces cell apoptosis and inhibits metastasis of cervical cancer by targeting NOB1

Cited by 63 publications

References 22 publications

Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139

Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139

Serum MicroRNA profile in patients with colon adenomas or cancer

MicroRNA‐612 inhibits cervical cancer progression by targeting NOB1

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